KEGG   PATHWAY: pti04145Help
Entry
pti04145                    Pathway                                

Name
Phagosome - Phaeodactylum tricornutum
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Phagosome
pti04145

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Other DBs
BSID: 
GO: 
Organism
Phaeodactylum tricornutum [GN:pti]
Gene
hypothetical protein; K05692 actin beta/gamma 1 [KO:K05692]
ACT1; actin/actin like protein [KO:K05692]
SybE; hypothetical protein [KO:K08517]
Rab5a; hypothetical protein [KO:K07889]
hypothetical protein; K00914 phosphatidylinositol 3-kinase [EC:2.7.1.137] [KO:K00914] [EC:2.7.1.137]
hypothetical protein; K02145 V-type H+-transporting ATPase subunit A [EC:3.6.3.14] [KO:K02145] [EC:3.6.3.14]
hypothetical protein; K02147 V-type H+-transporting ATPase subunit B [KO:K02147]
det3-like protein; K02148 V-type H+-transporting ATPase subunit C [KO:K02148]
hypothetical protein; K02149 V-type H+-transporting ATPase subunit D [KO:K02149]
hypothetical protein; K02150 V-type H+-transporting ATPase subunit E [KO:K02150]
hypothetical protein; K02151 V-type H+-transporting ATPase subunit F [KO:K02151]
hypothetical protein; K02152 V-type H+-transporting ATPase subunit G [KO:K02152]
hypothetical protein; K02154 V-type H+-transporting ATPase subunit a [KO:K02154]
hypothetical protein; K02146 V-type H+-transporting ATPase subunit d [KO:K02146]
hypothetical protein; K02144 V-type H+-transporting ATPase subunit H [KO:K02144]
hypothetical protein; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
hypothetical protein; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
hypothetical protein; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
hypothetical protein; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
hypothetical protein; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
hypothetical protein; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [KO:K03661]
Rab7; hypothetical protein [KO:K07897]
DHC1; hypothetical protein [KO:K10413]
hypothetical protein; K10415 dynein intermediate chain, cytosolic [KO:K10415]
hypothetical protein; K07374 tubulin alpha [KO:K07374]
hypothetical protein; K07375 tubulin beta [KO:K07375]
hypothetical protein; K01365 cathepsin L [EC:3.4.22.15] [KO:K01365] [EC:3.4.22.15]
Sec61alpha; transport protein Sec61 alpha subunit [KO:K10956]
hypothetical protein; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
calreticulin; K08057 calreticulin [KO:K08057]
Compound
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
KO pathway
 

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