| Entry |
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| Name |
RNA degradation - Picrophilus torridus
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| Description |
The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.
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| Class |
Genetic Information Processing; Folding, sorting and degradation
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| Pathway map |
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| Module |
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| Other DBs |
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| Organism |
Picrophilus torridus [GN: pto]
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| Gene |
| exosome complex RNA-binding protein Csl4; K07573 exosome complex component CSL4 [KO: K07573] | | exosome complex RNA-binding protein Rrp4; K03679 exosome complex component RRP4 [KO: K03679] | | exosome complex RNA-binding protein Rrp42; K12589 exosome complex component RRP42 [KO: K12589] | | exosome complex exonuclease Rrp41; K11600 exosome complex component RRP41 [KO: K11600] | | | | dnaK; molecular chaperone DnaK [KO: K04043] |
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| Compound |
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| Reference |
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| Authors |
Houseley J, Tollervey D |
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| Title |
The many pathways of RNA degradation. |
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| Journal |
Cell 136:763-76 (2009) |
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| Reference |
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| Authors |
Buttner K, Wenig K, Hopfner KP |
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| Title |
The exosome: a macromolecular cage for controlled RNA degradation. |
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| Journal |
Mol Microbiol 61:1372-9 (2006) |
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| Reference |
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| Authors |
Schilders G, van Dijk E, Raijmakers R, Pruijn GJ |
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| Title |
Cell and molecular biology of the exosome: how to make or break an RNA. |
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| Journal |
Int Rev Cytol 251:159-208 (2006) |
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| Reference |
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| Authors |
Hartung S, Hopfner KP |
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| Title |
The exosome, plugged. |
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| Journal |
EMBO Rep 8:456-7 (2007) |
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| Reference |
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| Authors |
Carpousis AJ |
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| Title |
The RNA degradosome of Escherichia coli: an mRNA-degrading machine assembled on RNase E. |
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| Journal |
Annu Rev Microbiol 61:71-87 (2007) |
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| Reference |
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| Authors |
Marcaida MJ, DePristo MA, Chandran V, Carpousis AJ, Luisi BF |
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| Title |
The RNA degradosome: life in the fast lane of adaptive molecular evolution. |
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| Journal |
Trends Biochem Sci 31:359-65 (2006) |
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| Reference |
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| Authors |
Condon C |
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| Title |
Maturation and degradation of RNA in bacteria. |
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| Journal |
Curr Opin Microbiol 10:271-8 (2007) |
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| KO pathway |
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