KEGG   PATHWAY: ptr00280
Entry
ptr00280                    Pathway                                
Name
Valine, leucine and isoleucine degradation - Pan troglodytes (chimpanzee)
Class
Metabolism; Amino acid metabolism
Pathway map
ptr00280  Valine, leucine and isoleucine degradation
ptr00280

Module
ptr_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:ptr00280]
ptr_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:ptr00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
465345  BCAT1; branched-chain-amino-acid aminotransferase, cytosolic isoform X1 [KO:K00826] [EC:2.6.1.42]
456189  BCAT2; branched-chain-amino-acid aminotransferase, mitochondrial isoform X1 [KO:K00826] [EC:2.6.1.42]
456223  IL4I1; L-amino-acid oxidase isoform X1 [KO:K03334] [EC:1.4.3.2]
468889  BCKDHA; 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor [KO:K00166] [EC:1.2.4.4]
462845  BCKDHB; 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1 [KO:K00167] [EC:1.2.4.4]
457056  DBT; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [KO:K09699] [EC:2.3.1.168]
463861  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
742921  ACADS; short-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00248] [EC:1.3.8.1]
469356  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor [KO:K00249] [EC:1.3.8.7]
453333  IVD; isovaleryl-CoA dehydrogenase, mitochondrial isoform X3 [KO:K00253] [EC:1.3.8.4]
745464  ACADSB; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K09478] [EC:1.3.8.5]
451683  ACAD8; isobutyryl-CoA dehydrogenase, mitochondrial isoform X3 [KO:K11538] [EC:1.3.99.-]
459079  HADHA; trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
460996  EHHADH; peroxisomal bifunctional enzyme isoform X2 [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
747936  ECHS1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
461424  HADH; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial isoform X1 [KO:K00022] [EC:1.1.1.35]
465649  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 isoform X2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
460268  ACAA1; 3-ketoacyl-CoA thiolase, peroxisomal isoform X1 [KO:K07513] [EC:2.3.1.16]
455414  ACAA2; 3-ketoacyl-CoA thiolase, mitochondrial isoform X2 [KO:K07508] [EC:2.3.1.16]
459080  HADHB; trifunctional enzyme subunit beta, mitochondrial precursor [KO:K07509] [EC:2.3.1.16]
738775  PCCA; propionyl-CoA carboxylase alpha chain, mitochondrial isoform X1 [KO:K01965] [EC:6.4.1.3]
104001059  PCCB; propionyl-CoA carboxylase beta chain, mitochondrial isoform X1 [KO:K01966] [EC:6.4.1.3 2.1.3.15]
459310  MCEE; methylmalonyl-CoA epimerase, mitochondrial isoform X2 [KO:K05606] [EC:5.1.99.1]
463198  MUT; methylmalonyl-CoA mutase, mitochondrial [KO:K01847] [EC:5.4.99.2]
459828  HIBCH; 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X2 [KO:K05605] [EC:3.1.2.4]
463313  HIBADH; 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X2 [KO:K00020] [EC:1.1.1.31]
467506  ALDH6A1; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [KO:K00140] [EC:1.2.1.18 1.2.1.27]
464931  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
454505  ALDH3A2; fatty aldehyde dehydrogenase isoform X1 [KO:K00128] [EC:1.2.1.3]
107967644  ALDH2; aldehyde dehydrogenase, mitochondrial isoform X1 [KO:K00128] [EC:1.2.1.3]
462033  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
457478  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
459863  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
747025  LOW QUALITY PROTEIN: aldehyde oxidase 2-like [KO:K00157] [EC:1.2.3.1]
454311  ACSF3; acyl-CoA synthetase family member 3, mitochondrial isoform X1 [KO:K18660] [EC:6.2.1.76 6.2.1.-]
453903  ABAT; 4-aminobutyrate aminotransferase, mitochondrial isoform X1 [KO:K13524] [EC:2.6.1.19 2.6.1.22]
471573  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
460872  MCCC1; methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial isoform X2 [KO:K01968] [EC:6.4.1.4]
461823  MCCC2; methylcrotonoyl-CoA carboxylase beta chain, mitochondrial isoform X2 [KO:K01969] [EC:6.4.1.4]
464587  AUH; methylglutaconyl-CoA hydratase, mitochondrial isoform X2 [KO:K05607] [EC:4.2.1.18]
470410  methylglutaconyl-CoA hydratase, mitochondrial-like isoform X1 [KO:K05607] [EC:4.2.1.18]
456624  HMGCL; hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1 [KO:K01640] [EC:4.1.3.4]
742364  HMGCLL1; 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform X1 [KO:K01640] [EC:4.1.3.4]
737468  OXCT1; succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial [KO:K01027] [EC:2.8.3.5]
456780  OXCT2; succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial [KO:K01027] [EC:2.8.3.5]
112209812  LOW QUALITY PROTEIN: succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial-like [KO:K01027] [EC:2.8.3.5]
452361  AACS; acetoacetyl-CoA synthetase isoform X1 [KO:K01907] [EC:6.2.1.16]
451528  ACAT1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
741276  ACAT2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
461892  HMGCS1; hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 [KO:K01641] [EC:2.3.3.10]
457169  HMGCS2; hydroxymethylglutaryl-CoA synthase, mitochondrial [KO:K01641] [EC:2.3.3.10]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
ptr00020  Citrate cycle (TCA cycle)
ptr00240  Pyrimidine metabolism
ptr00290  Valine, leucine and isoleucine biosynthesis
ptr00640  Propanoate metabolism
ptr00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (51)   
   KEGG GENES (51)   
All databases (52)   

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