KEGG PATHWAY: ptr04010

PATHWAY: ptr04010

Entry

ptr04010 Pathway

Name

MAPK signaling pathway - Pan troglodytes (chimpanzee)

Description

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.

Class

Environmental Information Processing; Signal transduction

Pathway map

ptr04010

MAPK signaling pathway

Organism

Pan troglodytes (chimpanzee) [GN:ptr]

Gene

455766	CACNA1A; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [KO:K04344]
464893	CACNA1B; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849]
466914	CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
460447	CACNA1D; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851]
457564	CACNA1E; calcium channel, voltage-dependent, R type, alpha 1E subunit [KO:K04852]
465629	CACNA1F; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
740711	voltage-dependent L-type calcium channel subunit alpha-1F-like; K04853 voltage-dependent calcium channel L type alpha-1F [KO:K04853]
455128	CACNA1G; calcium channel, voltage-dependent, T type, alpha 1G subunit [KO:K04854]
453813	CACNA1H; calcium channel, voltage-dependent, T type, alpha 1H subunit [KO:K04855]
458848	CACNA1I; calcium channel, voltage-dependent, T type, alpha 1I subunit [KO:K04856]
469635	CACNA1S; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857]
463504	CACNA2D1; calcium channel, voltage-dependent, alpha 2/delta subunit 1 [KO:K04858]
460396	CACNA2D2; calcium channel, voltage-dependent, alpha 2/delta subunit 2 [KO:K04859]
460457	CACNA2D3; calcium channel, voltage-dependent, alpha 2/delta subunit 3 [KO:K04860]
466912	CACNA2D4; calcium channel, voltage-dependent, alpha 2/delta subunit 4 [KO:K04861]
454624	CACNB1; calcium channel, voltage-dependent, beta 1 subunit [KO:K04862]
740138	CACNB2; calcium channel, voltage-dependent, beta 2 subunit [KO:K04863]
451867	CACNB3; calcium channel, voltage-dependent, beta 3 subunit [KO:K04864]
459660	CACNB4; calcium channel, voltage-dependent, beta 4 subunit [KO:K04865]
741106	CACNG1; calcium channel, voltage-dependent, gamma subunit 1 [KO:K04866]
458799	CACNG2; calcium channel, voltage-dependent, gamma subunit 2 [KO:K04867]
746707	CACNG3; calcium channel, voltage-dependent, gamma subunit 3 [KO:K04868]
741406	CACNG4; calcium channel, voltage-dependent, gamma subunit 4 [KO:K04869]
100609964	CACNG5; calcium channel, voltage-dependent, gamma subunit 5 [KO:K04870]
749208	CACNG6; calcium channel, voltage-dependent, gamma subunit 6 [KO:K04871]
749196	CACNG7; calcium channel, voltage-dependent, gamma subunit 7 [KO:K04872]
101058889	CACNG8; calcium channel, voltage-dependent, gamma subunit 8 [KO:K04873]
469367	PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
472944	PRKACG; protein kinase, cAMP-dependent, catalytic, gamma [KO:K04345] [EC:2.7.11.11]
449495	PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
455776	PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
751063	cAMP-dependent protein kinase catalytic subunit PRKX-like; K04345 protein kinase A [EC:2.7.11.11] [KO:K04345] [EC:2.7.11.11]
454832	PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
456276	PRKCG; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
453993	PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
463234	GNA12; guanine nucleotide binding protein (G protein) alpha 12 [KO:K04346]
100609242	GNG12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
468737	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like; K04347 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
742406	PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
461403	PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
450898	PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
736325	PPP3R2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
467662	CHP1; calcineurin-like EF hand protein 1 [KO:K06268]
467926	CHP2; calcineurin-like EF hand protein 2 [KO:K06268]
100613118	PPP3R1; protein phosphatase 3, regulatory subunit B, alpha [KO:K06268]
453575	RASGRF1; Ras protein-specific guanine nucleotide-releasing factor 1 [KO:K04349]
461771	RASGRF2; Ras protein-specific guanine nucleotide-releasing factor 2 [KO:K12326]
453316	RASGRP1; RAS guanyl releasing protein 1 (calcium and DAG-regulated) [KO:K04350]
451298	RASGRP2; RAS guanyl releasing protein 2 (calcium and DAG-regulated) [KO:K12361]
470348	RASGRP3; RAS guanyl releasing protein 3 (calcium and DAG-regulated) [KO:K12362]
468867	RASGRP4; RAS guanyl releasing protein 4 [KO:K12363]
461577	RAPGEF2; Rap guanine nucleotide exchange factor (GEF) 2 [KO:K08018]
454566	NF1; neurofibromin 1 [KO:K08052]
461762	RASA1; RAS p21 protein activator (GTPase activating protein) 1 [KO:K04352]
460741	RASA2; RAS p21 protein activator 2 [KO:K08053]
469408	RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
452065	RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
469423	NGF; nerve growth factor (beta polypeptide) [KO:K02582]
503511	BDNF; brain-derived neurotrophic factor [KO:K04355]
466931	NTF3; neurotrophin 3 [KO:K04356]
747850	NTF4; neurotrophin 4 [KO:K12457]
461435	EGF; epidermal growth factor [KO:K04357]
747181	FGF6; fibroblast growth factor 6 [KO:K04358]
747164	FGF23; fibroblast growth factor 23 [KO:K04358]
471041	FGF12; fibroblast growth factor 12 [KO:K04358]
468948	FGF21; fibroblast growth factor 21 [KO:K04358]
472708	FGF17; fibroblast growth factor 17 [KO:K04358]
471553	FGF10; fibroblast growth factor 10 [KO:K04358]
465886	FGF13; fibroblast growth factor 13 [KO:K04358]
468631	FGF22; fibroblast growth factor 22 [KO:K04358]
462158	FGF1; fibroblast growth factor 1 (acidic) [KO:K04358]
744975	FGF7; fibroblast growth factor 7 [KO:K04358]
473676	FGF16; fibroblast growth factor 16 [KO:K04358]
471190	FGF5; fibroblast growth factor 5 [KO:K04358]
748965	FGF11; fibroblast growth factor 11 [KO:K04358]
739611	FGF18; fibroblast growth factor 18 [KO:K04358]
747727	FGF4; fibroblast growth factor 4 [KO:K04358]
466693	FGF3; fibroblast growth factor 3 [KO:K04358]
739665	FGF20; fibroblast growth factor 20 [KO:K04358]
739338	FGF14; fibroblast growth factor 14 [KO:K04358]
744731	FGF9; fibroblast growth factor 9 (glia-activating factor) [KO:K04358]
641462	FGF2; fibroblast growth factor 2 (basic) [KO:K04358]
101056934	FGF8; fibroblast growth factor 8 (androgen-induced) [KO:K04358]
747710	FGF19; fibroblast growth factor 19 [KO:K04358]
458844	PDGFB; platelet-derived growth factor beta polypeptide [KO:K04359]
740202	PDGFA; platelet-derived growth factor alpha polypeptide [KO:K04359]
457408	NTRK1; neurotrophic tyrosine kinase, receptor, type 1 [KO:K03176] [EC:2.7.10.1]
735394	NTRK2; neurotrophic tyrosine kinase, receptor, type 2 [KO:K04360] [EC:2.7.10.1]
463415	EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
464122	FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
466220	FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
461067	FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
462301	FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
461318	PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
462188	PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
737245	GRB2; growth factor receptor-bound protein 2 [KO:K04364]
459171	SOS1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
452897	SOS2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
466302	HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog [KO:K02833]
473387	KRAS; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
742713	NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
468955	RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
451038	RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
470938	MRAS; muscle RAS oncogene homolog [KO:K07831]
463781	BRAF; v-raf murine sarcoma viral oncogene homolog B1 [KO:K04365] [EC:2.7.11.1]
460182	RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [KO:K04366] [EC:2.7.11.1]
472772	MOS; v-mos Moloney murine sarcoma viral oncogene homolog [KO:K04367] [EC:2.7.11.1]
450188	MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
456390	MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100611792	dual specificity mitogen-activated protein kinase kinase 2-like; K04369 mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] [KO:K04369] [EC:2.7.12.2]
461399	LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
454037	MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
458680	MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
469189	MKNK1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
455561	MKNK2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
450110	RPS6KA3; ribosomal protein S6 kinase, 90kDa, polypeptide 3 [KO:K04373] [EC:2.7.11.1]
456664	RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1 [KO:K04373] [EC:2.7.11.1]
463127	RPS6KA2; ribosomal protein S6 kinase, 90kDa, polypeptide 2 [KO:K04373] [EC:2.7.11.1]
743327	RPS6KA6; ribosomal protein S6 kinase, 90kDa, polypeptide 6 [KO:K04373] [EC:2.7.11.1]
744513	ATF4; activating transcription factor 4 (tax-responsive enhancer element B67) [KO:K04374]
473591	ELK1; ELK1, member of ETS oncogene family [KO:K04375]
742304	ELK4; ELK4, ETS-domain protein (SRF accessory protein 1) [KO:K04376]
464393	MYC; v-myc myelocytomatosis viral oncogene homolog (avian) [KO:K04377]
462709	SRF; serum response factor (c-fos serum response element-binding transcription factor) [KO:K04378]
453047	FOS; FBJ murine osteosarcoma viral oncogene homolog [KO:K04379]
450177	MAPT; microtubule-associated protein tau [KO:K04380]
456650	STMN1; stathmin 1 [KO:K04381]
467664	PLA2G4E; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
469617	PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342] [EC:3.1.1.4]
453706	cytosolic phospholipase A2 beta-like; K16342 cytosolic phospholipase A2 [EC:3.1.1.4] [KO:K16342] [EC:3.1.1.4]
747584	PLA2G4B; phospholipase A2, group IVB (cytosolic) [KO:K16342] [EC:3.1.1.4]
468935	PLA2G4C; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4]
100610135	PLA2G4D; phospholipase A2, group IVD (cytosolic) [KO:K16342] [EC:3.1.1.4]
453356	PLA2G4F; phospholipase A2, group IVF [KO:K16342] [EC:3.1.1.4]
739598	PLA2G4B; phospholipase A2, group IVB [KO:K16342] [EC:3.1.1.4]
749457	PLA2G4B; phospholipase A2, group IVB [KO:K16342] [EC:3.1.1.4]
739798	PLA2G4B; phospholipase A2, group IVB [KO:K16342] [EC:3.1.1.4]
740368	PLA2G4B; phospholipase A2, group IVB [KO:K16342] [EC:3.1.1.4]
748705	PLA2G4B; phospholipase A2, group IVB [KO:K16342] [EC:3.1.1.4]
494186	TNF; tumor necrosis factor [KO:K03156]
470485	IL1A; interleukin 1, alpha [KO:K04383]
450200	IL1B; interleukin 1, beta [KO:K04519]
456060	TGFB1; transforming growth factor, beta 1 [KO:K13375]
457742	TGFB2; transforming growth factor, beta 2 [KO:K13376]
453054	TGFB3; transforming growth factor, beta 3 [KO:K13377]
466934	TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A [KO:K03158]
459460	IL1R1; interleukin 1 receptor, type I [KO:K04386]
470455	IL1R2; interleukin 1 receptor, type II [KO:K04387]
472992	TGFBR1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
460243	TGFBR2; transforming growth factor, beta receptor II (70/80kDa) [KO:K04388] [EC:2.7.11.30]
469584	FASLG; Fas ligand (TNF superfamily, member 6) [KO:K04389]
738331	FAS; Fas (TNF receptor superfamily, member 6) [KO:K04390]
462118	CD14; CD14 molecule [KO:K04391]
741907	RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
742575	RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
747131	uncharacterized LOC747131; K07861 Ras-related C3 botulinum toxin substrate 3 [KO:K07861]
745248	cell division control protein 42 homolog; K04393 cell division control protein 42 [KO:K04393]
456609	CDC42; cell division cycle 42 (GTP binding protein, 25kDa) [KO:K04393]
461669	CASP3; caspase 3, apoptosis-related cysteine peptidase [KO:K02187] [EC:3.4.22.56]
464876	TRAF2; TNF receptor-associated factor 2 [KO:K03173]
462613	DAXX; death-domain associated protein [KO:K02308]
451702	TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
464585	GADD45G; growth arrest and DNA-damage-inducible, gamma [KO:K04402]
744311	GADD45B; growth arrest and DNA-damage-inducible, beta [KO:K04402]
456929	GADD45A; growth arrest and DNA-damage-inducible, alpha [KO:K04402]
458845	TAB1; TGF-beta activated kinase 1/MAP3K7 binding protein 1 [KO:K04403]
463057	TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
455733	ECSIT; ECSIT homolog (Drosophila) [KO:K04405]
459173	MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
459459	MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
748652	MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
451439	PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
460965	PAK2; p21 protein (Cdc42/Rac)-activated kinase 2 [KO:K04410] [EC:2.7.11.1]
458275	STK4; serine/threonine kinase 4 [KO:K04411]
472829	STK3; serine/threonine kinase 3 [KO:K04412]
451301	MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
450384	MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
471543	MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [KO:K04416] [EC:2.7.11.25]
451326	MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
736244	MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
468286	MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
737524	MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
451940	MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
459745	mitogen-activated protein kinase kinase kinase MLT-like; K04424 sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25] [KO:K04424] [EC:2.7.11.25]
456674	MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
463023	MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
462888	MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
463119	MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
452292	TAOK3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
454548	TAOK1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
454033	TAOK2; TAO kinase 2 [KO:K04429] [EC:2.7.11.1]
455065	MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
743199	MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
746715	dual specificity mitogen-activated protein kinase kinase 3-like; K04432 mitogen-activated protein kinase kinase 3 [EC:2.7.12.2] [KO:K04432] [EC:2.7.12.2]
454515	MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
468310	MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
451148	MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
458945	MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
453825	MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
460476	FLNB; filamin B, beta [KO:K04437]
463711	FLNC; filamin C, gamma [KO:K04437]
470146	CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like [KO:K04438]
747142	CRK; v-crk sarcoma virus CT10 oncogene homolog (avian) [KO:K04438]
454450	ARRB2; arrestin, beta 2 [KO:K04439]
451424	ARRB1; arrestin, beta 1 [KO:K04439]
450445	MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
461358	MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
462336	MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
450161	MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
462644	MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
747077	MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
738233	MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
744091	MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
460400	MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
739162	RPS6KA5; ribosomal protein S6 kinase, 90kDa, polypeptide 5 [KO:K04445] [EC:2.7.11.1]
451715	RPS6KA4; ribosomal protein S6 kinase, 90kDa, polypeptide 4 [KO:K16510] [EC:2.7.11.1]
458064	CDC25B; cell division cycle 25 homolog B (S. pombe) [KO:K05866] [EC:3.1.3.48]
456893	JUN; jun proto-oncogene [KO:K04448]
739083	ATF2; activating transcription factor 2 [KO:K04450]
101059354	ATF2; activating transcription factor 2 [KO:K04450]
455214	TP53; tumor protein p53 [KO:K04451]
452017	DDIT3; DNA-damage-inducible transcript 3 [KO:K04452]
452972	MAX; MYC associated factor X [KO:K04453]
461760	MEF2C; myocyte enhancer factor 2C [KO:K04454]
463488	HSPB1; heat shock 27kDa protein 1 [KO:K04455]
456035	AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
740898	AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
100609583	AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
452950	PPM1A; protein phosphatase, Mg2+/Mn2+ dependent, 1A [KO:K04457] [EC:3.1.3.16]
452076	PTPRR; protein tyrosine phosphatase, receptor type, R [KO:K04458] [EC:3.1.3.48]
739158	PTPN7; protein tyrosine phosphatase, non-receptor type 7 [KO:K04458] [EC:3.1.3.48]
466462	PTPN5; protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) [KO:K04458] [EC:3.1.3.48]
452115	DUSP6; dual specificity phosphatase 6 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
471742	DUSP1; dual specificity phosphatase 1 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
470826	DUSP7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
468271	DUSP3; dual specificity phosphatase 3 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
469145	DUSP10; dual specificity phosphatase 10 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
464497	DUSP4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
465297	DUSP16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
746336	dual specificity protein phosphatase 8-like; K04459 dual specificity phosphatase [EC:3.1.3.16 3.1.3.48] [KO:K04459] [EC:3.1.3.48 3.1.3.16]
468226	DUSP14; dual specificity phosphatase 14 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
740713	DUSP9; dual specificity phosphatase 9 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
738584	DUSP5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
750495	DUSP22; dual specificity phosphatase 22 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
456150	PPP5C; protein phosphatase 5, catalytic subunit [KO:K04460] [EC:3.1.3.16]
470365	PPM1B; protein phosphatase, Mg2+/Mn2+ dependent, 1B [KO:K04461] [EC:3.1.3.16]
450139	HSPA2; heat shock 70kDa protein 2 [KO:K03283]
471967	HSPA1L; heat shock 70kDa protein 1-like [KO:K03283]
451629	HSPA8; heat shock 70kDa protein 8 [KO:K03283]
100608888	HSPA1A; heat shock 70kDa protein 1A [KO:K03283]
460837	MECOM; MDS1 and EVI1 complex locus [KO:K04462]
453532	MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
454499	MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
451913	NR4A1; nuclear receptor subfamily 4, group A, member 1 [KO:K04465]
454750	MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
450673	CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
472749	IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
100610002	NF-kappa-B essential modulator-like; K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma [KO:K07210]
739132	NLK; nemo-like kinase [KO:K04468] [EC:2.7.11.24]
461406	NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
450697	NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) [KO:K04469]
466665	RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
456119	RELB; v-rel reticuloendotheliosis viral oncogene homolog B [KO:K09253]
452821	NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 [KO:K04446]
469972	NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [KO:K04446]

Compound

C00076	Calcium cation
C00165	Diacylglycerol
C00338	Lipopolysaccharide
C00575	3',5'-Cyclic AMP
C01245	D-myo-Inositol 1,4,5-trisphosphate

Reference

PMID:11749383

Authors

Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.

Title

MAP kinases.

Journal

Chem Rev 101:2449-76 (2001)

Reference

PMID:12191611

Authors

Tanoue T, Nishida E.

Title

Docking interactions in the mitogen-activated protein kinase cascades.

Journal

Pharmacol Ther 93:193-202 (2002)

Reference

PMID:12947395

Authors

Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.

Title

MAPK pathways in radiation responses.

Journal

Oncogene 22:5885-96 (2003)

Reference

PMID:12676795

Authors

Huang EJ, Reichardt LF.

Title

Trk receptors: roles in neuronal signal transduction.

Journal

Annu Rev Biochem 72:609-42 (2003)

Reference

PMID:11369511

Authors

Harper SJ, LoGrasso P.

Title

Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.

Journal

Cell Signal 13:299-310 (2001)

Reference

PMID:12390245

Authors

Takeda K, Ichijo H.

Title

Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.

Journal

Genes Cells 7:1099-111 (2002)

Reference

PMID:14597384

Authors

Yang SH, Sharrocks AD, Whitmarsh AJ.

Title

Transcriptional regulation by the MAP kinase signaling cascades.

Journal

Gene 320:3-21 (2003)

Reference

PMID:12566928

Authors

Zhu X, Lee HG, Raina AK, Perry G, Smith MA.

Title

The role of mitogen-activated protein kinase pathways in Alzheimer's disease.

Journal

Neurosignals 11:270-81 (2002)

Reference

PMID:12849693

Authors

Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.

Title

Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.

Journal

Toxicol Lett 143:323-30 (2003)

KO pathway

ko04010

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Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (265)   
   KEGG GENES (265)   
All databases (267)   

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