KEGG PATHWAY: ptr04120

PATHWAY: ptr04120

Entry

ptr04120 Pathway

Name

Ubiquitin mediated proteolysis - Pan troglodytes (chimpanzee)

Description

Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.

Class

Genetic Information Processing; Folding, sorting and degradation

Pathway map

ptr04120

Ubiquitin mediated proteolysis

Module

ptr_M00379	SCF-MET30 complex [PATH:ptr04120]
ptr_M00380	SCF-BTRC complex [PATH:ptr04120]
ptr_M00381	SCF-SKP2 complex [PATH:ptr04120]
ptr_M00382	SCF-FBS complex [PATH:ptr04120]
ptr_M00383	ECV complex [PATH:ptr04120]
ptr_M00384	Cul3-SPOP complex [PATH:ptr04120]
ptr_M00385	Cul4-DDB1-DDB2 complex [PATH:ptr04120]
ptr_M00386	Cul4-DDB1-CSA complex [PATH:ptr04120]
ptr_M00387	SCF-FBW7 complex [PATH:ptr04120]
ptr_M00388	ECS complex [PATH:ptr04120]
ptr_M00389	APC/C complex [PATH:ptr04120]
ptr_M00407	SCF-CDC4 complex [PATH:ptr04120]
ptr_M00411	SCF-GRR1 complex [PATH:ptr04120]

Other DBs

BSID:

83772

GO:

0016567

Organism

Pan troglodytes (chimpanzee) [GN:ptr]

Gene

749307	UBA1; ubiquitin-like modifier activating enzyme 1 [KO:K03178] [EC:6.3.2.19]
456159	SAE1; SUMO1 activating enzyme subunit 1 [KO:K10684] [EC:6.3.2.19]
468823	UBA2; ubiquitin-like modifier activating enzyme 2 [KO:K10685] [EC:6.3.2.19]
460496	UBA3; ubiquitin-like modifier activating enzyme 3 [KO:K10686] [EC:6.3.2.19]
744322	UBA7; ubiquitin-like modifier activating enzyme 7 [KO:K10698] [EC:6.3.2.19]
461294	UBA6; ubiquitin-like modifier activating enzyme 6 [KO:K10699] [EC:6.3.2.19]
737175	UBE2A; ubiquitin-conjugating enzyme E2A [KO:K10573] [EC:6.3.2.19]
462065	UBE2B; ubiquitin-conjugating enzyme E2B [KO:K10574] [EC:6.3.2.19]
458287	UBE2C; ubiquitin-conjugating enzyme E2C [KO:K06688] [EC:6.3.2.19]
745118	UBE2D3; ubiquitin-conjugating enzyme E2D 3 [KO:K06689] [EC:6.3.2.19]
459792	UBE2E3; ubiquitin-conjugating enzyme E2E 3 [KO:K06689] [EC:6.3.2.19]
745141	UBE2D1; ubiquitin-conjugating enzyme E2D 1 [KO:K06689] [EC:6.3.2.19]
462108	UBE2D2; ubiquitin-conjugating enzyme E2D 2 [KO:K06689] [EC:6.3.2.19]
460225	UBE2E2; ubiquitin-conjugating enzyme E2E 2 [KO:K06689] [EC:6.3.2.19]
750105	UBE2E1; ubiquitin-conjugating enzyme E2E 1 [KO:K06689] [EC:6.3.2.19]
461941	UBE2D3; ubiquitin-conjugating enzyme E2 D3-like [KO:K06689] [EC:6.3.2.19]
460054	UBE2F; ubiquitin-conjugating enzyme E2F (putative) [KO:K10687] [EC:6.3.2.19]
750513	UBE2G1; ubiquitin-conjugating enzyme E2G 1 [KO:K10575] [EC:6.3.2.19]
474042	UBE2G2; ubiquitin-conjugating enzyme E2G 2 [KO:K04555] [EC:6.3.2.19]
741944	UBE2H; ubiquitin-conjugating enzyme E2H [KO:K10576] [EC:6.3.2.19]
749975	UBE2I; ubiquitin-conjugating enzyme E2I [KO:K10577] [EC:6.3.2.19]
462883	UBE2J1; ubiquitin-conjugating enzyme E2, J1 [KO:K10578] [EC:6.3.2.19]
457188	UBE2J2; ubiquitin-conjugating enzyme E2, J2 [KO:K04554] [EC:6.3.2.19]
452921	ubiquitin-conjugating enzyme E2 L3-like; K04552 ubiquitin-conjugating enzyme E2 L3 [EC:6.3.2.19] [KO:K04552] [EC:6.3.2.19]
748061	UBE2L3; ubiquitin-conjugating enzyme E2L 3 [KO:K04552] [EC:6.3.2.19]
466588	UBE2L6; ubiquitin-conjugating enzyme E2L 6 [KO:K04553] [EC:6.3.2.19]
742993	UBE2M; ubiquitin-conjugating enzyme E2M [KO:K10579] [EC:6.3.2.19]
452125	UBE2N; ubiquitin-conjugating enzyme E2N [KO:K10580] [EC:6.3.2.19]
100615866	UBE2NL; ubiquitin-conjugating enzyme E2N-like [KO:K10580] [EC:6.3.2.19]
468335	UBE2O; ubiquitin-conjugating enzyme E2O [KO:K10581] [EC:6.3.2.19]
740158	UBE2Q1; ubiquitin-conjugating enzyme E2Q family member 1 [KO:K10582] [EC:6.3.2.19]
453772	UBE2Q2; ubiquitin-conjugating enzyme E2Q family member 2 [KO:K10582] [EC:6.3.2.19]
750981	UBE2QL1; ubiquitin-conjugating enzyme E2Q family-like 1 [KO:K10582] [EC:6.3.2.19]
747027	UBE2R2; ubiquitin-conjugating enzyme E2R 2 [KO:K02207] [EC:6.3.2.19]
456304	UBE2S; ubiquitin-conjugating enzyme E2S [KO:K10583] [EC:6.3.2.19]
469342	UBE2U; ubiquitin-conjugating enzyme E2U (putative) [KO:K10584] [EC:6.3.2.19]
464234	UBE2W; ubiquitin-conjugating enzyme E2W (putative) [KO:K10688] [EC:6.3.2.19]
455196	UBE2Z; ubiquitin-conjugating enzyme E2Z [KO:K10585] [EC:6.3.2.19]
461178	UBE2K; ubiquitin-conjugating enzyme E2K [KO:K04649] [EC:6.3.2.19]
459138	BIRC6; baculoviral IAP repeat containing 6 [KO:K10586] [EC:6.3.2.19]
453269	UBE3A; ubiquitin protein ligase E3A [KO:K10587] [EC:6.3.2.19]
452223	UBE3B; ubiquitin protein ligase E3B [KO:K10588] [EC:6.3.2.19]
472637	UBE3C; ubiquitin protein ligase E3C [KO:K10589] [EC:6.3.2.19]
454761	SMURF2; SMAD specific E3 ubiquitin protein ligase 2 [KO:K04678] [EC:6.3.2.19]
472670	SMURF1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:6.3.2.19]
458191	ITCH; itchy E3 ubiquitin protein ligase [KO:K05632] [EC:6.3.2.19]
464269	WWP1; WW domain containing E3 ubiquitin protein ligase 1 [KO:K05633] [EC:6.3.2.19]
743862	WWP2; WW domain containing E3 ubiquitin protein ligase 2 [KO:K05630] [EC:6.3.2.19]
459994	TRIP12; thyroid hormone receptor interactor 12 [KO:K10590] [EC:6.3.2.19]
467689	NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:6.3.2.19]
455443	NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:6.3.2.19]
465650	HUWE1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase [KO:K10592] [EC:6.3.2.19]
464322	UBR5; ubiquitin protein ligase E3 component n-recognin 5 [KO:K10593] [EC:6.3.2.19]
453500	HERC1; HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [KO:K10594] [EC:6.3.2.19]
465464	E3 ubiquitin-protein ligase HERC2-like; K10595 E3 ubiquitin-protein ligase HERC2 [EC:6.3.2.19] [KO:K10595] [EC:6.3.2.19]
453257	E3 ubiquitin-protein ligase HERC2-like; K10595 E3 ubiquitin-protein ligase HERC2 [EC:6.3.2.19] [KO:K10595] [EC:6.3.2.19]
461371	HERC3; HECT and RLD domain containing E3 ubiquitin protein ligase 3 [KO:K10614] [EC:6.3.2.19]
450495	HERC4; HECT and RLD domain containing E3 ubiquitin protein ligase 4 [KO:K10615] [EC:6.3.2.19]
451586	UBE4A; ubiquitination factor E4A [KO:K10596] [EC:6.3.2.19]
457924	UBE4B; ubiquitination factor E4B [KO:K10597] [EC:6.3.2.19]
453803	STUB1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase [KO:K09561] [EC:6.3.2.19]
458678	PPIL2; peptidylprolyl isomerase (cyclophilin)-like 2 [KO:K10598] [EC:5.2.1.8]
451228	PRPF19; PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) [KO:K10599] [EC:6.3.2.19]
746888	UBOX5; U-box domain containing 5 [KO:K10600]
742141	MDM2; Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) [KO:K06643] [EC:6.3.2.19]
451690	CBL; Cbl proto-oncogene, E3 ubiquitin protein ligase [KO:K04707] [EC:6.3.2.19]
460566	CBLB; Cbl proto-oncogene, E3 ubiquitin protein ligase B [KO:K04707] [EC:6.3.2.19]
456117	CBLC; Cbl proto-oncogene, E3 ubiquitin protein ligase C [KO:K04707] [EC:6.3.2.19]
741350	PARK2; parkinson protein 2, E3 ubiquitin protein ligase (parkin) [KO:K04556] [EC:6.3.2.19]
465153	SIAH1; siah E3 ubiquitin protein ligase 1 [KO:K04506] [EC:6.3.2.19]
473557	E3 ubiquitin-protein ligase SIAH1-like; K04506 E3 ubiquitin-protein ligase SIAH1 [EC:6.3.2.19] [KO:K04506] [EC:6.3.2.19]
453736	PML; promyelocytic leukemia [KO:K10054]
451702	TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
471543	MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [KO:K04416] [EC:2.7.11.25]
457541	RFWD2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase [KO:K10143] [EC:6.3.2.19]
461248	RCHY1; ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase [KO:K10144] [EC:6.3.2.19]
451508	BIRC2; baculoviral IAP repeat containing 2 [KO:K16060]
451507	BIRC3; baculoviral IAP repeat containing 3 [KO:K16060]
473765	XIAP; X-linked inhibitor of apoptosis [KO:K04725]
746160	BIRC7; baculoviral IAP repeat containing 7 [KO:K16061]
450113	BIRC8; baculoviral IAP repeat containing 8 [KO:K16061]
467715	PIAS1; protein inhibitor of activated STAT, 1 [KO:K04706] [EC:6.3.2.-]
455403	PIAS2; protein inhibitor of activated STAT, 2 [KO:K16063] [EC:6.3.2.-]
457223	PIAS3; protein inhibitor of activated STAT, 3 [KO:K16064] [EC:6.3.2.-]
736762	PIAS4; protein inhibitor of activated STAT, 4 [KO:K16065] [EC:6.3.2.-]
466660	SYVN1; synovial apoptosis inhibitor 1, synoviolin [KO:K10601] [EC:6.3.2.19]
747581	NHLRC1; NHL repeat containing 1 [KO:K10602] [EC:6.3.2.19]
474134	AIRE; autoimmune regulator [KO:K10603]
453884	MGRN1; mahogunin ring finger 1, E3 ubiquitin protein ligase [KO:K10604] [EC:6.3.2.19]
449497	BRCA1; breast cancer 1, early onset [KO:K10605]
459251	FANCL; Fanconi anemia, complementation group L [KO:K10606] [EC:6.3.2.19]
741750	MID1; midline 1 (Opitz/BBB syndrome) [KO:K08285] [EC:6.3.2.19]
742944	TRIM32; tripartite motif containing 32 [KO:K10607] [EC:6.3.2.19]
455163	TRIM37; tripartite motif containing 37 [KO:K10608]
458860	RBX1; ring-box 1, E3 ubiquitin protein ligase [KO:K03868]
463821	CUL1; cullin 1 [KO:K03347]
462063	SKP1; S-phase kinase-associated protein 1 [KO:K03094]
750875	S-phase kinase-associated protein 1-like; K03094 S-phase kinase-associated protein 1 [KO:K03094]
741033	S-phase kinase-associated protein 1-like; K03094 S-phase kinase-associated protein 1 [KO:K03094]
450685	BTRC; beta-transducin repeat containing E3 ubiquitin protein ligase [KO:K03362]
462263	FBXW11; F-box and WD repeat domain containing 11 [KO:K03362]
471570	SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase [KO:K03875]
461542	FBXW7; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase [KO:K10260]
457951	FBXO2; F-box protein 2 [KO:K10099]
737372	FBXO4; F-box protein 4 [KO:K10291]
450399	CUL2; cullin 2 [KO:K03870]
464236	TCEB1; transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) [KO:K03872]
750134	TCEB2; transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) [KO:K03873]
749769	VHL; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase [KO:K03871]
744812	CUL3; cullin 3 [KO:K03869]
455706	KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
465018	KLHL9; kelch-like 9 (Drosophila) [KO:K10447]
473752	KLHL13; kelch-like 13 (Drosophila) [KO:K10447]
464050	RHOBTB2; Rho-related BTB domain containing 2 [KO:K07868]
450482	RHOBTB1; Rho-related BTB domain containing 1 [KO:K07868]
452694	CUL4A; cullin 4A [KO:K10609]
451234	DDB1; damage-specific DNA binding protein 1, 127kDa [KO:K10610]
451165	DDB2; damage-specific DNA binding protein 2, 48kDa [KO:K10140]
471534	ERCC8; excision repair cross-complementing rodent repair deficiency, complementation group 8 [KO:K10570]
744350	DET1; de-etiolated homolog 1 (Arabidopsis) [KO:K10571]
100612089	RNF7; ring finger protein 7 [KO:K10611]
466773	CUL5; cullin 5 [KO:K10612]
737070	SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
454921	SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
472011	CUL7; cullin 7 [KO:K10613]
452285	FBXW8; F-box and WD repeat domain containing 8 [KO:K10264]
454972	ANAPC11; anaphase promoting complex subunit 11 [KO:K03358]
465174	ANAPC2; anaphase promoting complex subunit 2 [KO:K03349]
456819	CDC20; cell division cycle 20 homolog (S. cerevisiae) [KO:K03363]
468665	FZR1; fizzy/cell division cycle 20 related 1 (Drosophila) [KO:K03364]
459381	ANAPC1; anaphase promoting complex subunit 1 [KO:K03348]
735949	ANAPC1; anaphase promoting complex subunit 1 [KO:K03348]
454815	CDC27; cell division cycle 27 homolog (S. cerevisiae) [KO:K03350]
461149	ANAPC4; anaphase promoting complex subunit 4 [KO:K03351]
452321	ANAPC5; anaphase promoting complex subunit 5 [KO:K03352]
452688	CDC16; cell division cycle 16 homolog (S. cerevisiae) [KO:K03353]
467128	ANAPC7; anaphase promoting complex subunit 7 [KO:K03354]
462092	CDC23; cell division cycle 23 homolog (S. cerevisiae) [KO:K03355]
739629	ANAPC10; anaphase promoting complex subunit 10 [KO:K03357]
473026	CDC26; cell division cycle 26 homolog (S. cerevisiae) [KO:K03359]
460984	ANAPC13; anaphase promoting complex subunit 13 [KO:K12456]

Reference

PMID:16922370 (Japanese)

Authors

Kamura T.

Title

[Cullin-based E3 family] Japanese

Journal

Tanpakushitsu Kakusan Koso 51:1167-72 (2006)

Reference

PMID:16922408 (Japanese)

Authors

Matsuda N.

Title

[Overview: hereditary disorders caused by dysfunction of ubiquitylation]

Journal

Tanpakushitsu Kakusan Koso 51:1402-7 (2006)

Reference

PMID:16922367 (Japanese)

Authors

Tokunaga F.

Title

[E2 ubiquitin-conjugating enzymes: structures and functions]

Journal

Tanpakushitsu Kakusan Koso 51:1150-6 (2006)

Reference

PMID:16816840

Authors

Nalepa G, Rolfe M, Harper JW.

Title

Drug discovery in the ubiquitin-proteasome system.

Journal

Nat Rev Drug Discov 5:596-613 (2006)

Reference

PMID:16405856

Authors

Hsu YJ, Goodman SR.

Title

Spectrin and ubiquitination: a review.

Journal

Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)

Reference

PMID:12944364

Authors

Hatakeyama S, Nakayama KI.

Title

Ubiquitylation as a quality control system for intracellular proteins.

Journal

J Biochem 134:1-8 (2003)

Reference

PMID:17588513

Authors

Lee J, Zhou P.

Title

DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.

Journal

Mol Cell 26:775-80 (2007)

KO pathway

ko04120

All links

Pathway (11)   
   KEGG MODULE (10)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (141)   
   KEGG GENES (141)   
All databases (153)   

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