KEGG PATHWAY: ptr04620

PATHWAY: ptr04620

Entry

ptr04620 Pathway

Name

Toll-like receptor signaling pathway - Pan troglodytes (chimpanzee)

Description

Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.

Class

Organismal Systems; Immune system

Pathway map

ptr04620

Toll-like receptor signaling pathway

Organism

Pan troglodytes (chimpanzee) [GN:ptr]

Gene

461167	TLR1; toll-like receptor 1 [KO:K05398]
471325	TLR2; toll-like receptor 2 [KO:K10159]
471167	TLR6; toll-like receptor 6 [KO:K10169]
458239	LBP; lipopolysaccharide binding protein [KO:K05399]
462118	CD14; CD14 molecule [KO:K04391]
746178	LY96; lymphocyte antigen 96 [KO:K05400]
471374	TLR3; toll-like receptor 3 [KO:K05401]
743242	TLR4; toll-like receptor 4 [KO:K10160]
457762	TLR5; toll-like receptor 5 [KO:K10168]
473521	TLR7; toll-like receptor 7 [KO:K05404]
473522	TLR8; toll-like receptor 8 [KO:K10170]
457278	CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
470827	TLR9; toll-like receptor 9 [KO:K10161]
741907	RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
463649	PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
460858	PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
457922	PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
471079	PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
456565	PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
461836	PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
455085	PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
455855	PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
456035	AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
740898	AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
100609583	AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
450943	TOLLIP; toll interacting protein [KO:K05402]
460269	MYD88; myeloid differentiation primary response gene (88) [KO:K04729]
451654	TIRAP; toll-interleukin 1 receptor (TIR) domain containing adaptor protein [KO:K05403]
451389	FADD; Fas (TNFRSF6)-associated via death domain [KO:K02373]
746477	CASP8; caspase 8, apoptosis-related cysteine peptidase [KO:K04398] [EC:3.4.22.61]
466962	IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
465935	IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
451702	TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
458845	TAB1; TGF-beta activated kinase 1/MAP3K7 binding protein 1 [KO:K04403]
463057	TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
462888	MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
100610002	NF-kappa-B essential modulator-like; K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma [KO:K07210]
450673	CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
472749	IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
467426	NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
461406	NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
466665	RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
450384	MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
450188	MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
456390	MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100611792	dual specificity mitogen-activated protein kinase kinase 2-like; K04369 mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] [KO:K04369] [EC:2.7.12.2]
454037	MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
458680	MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
746715	dual specificity mitogen-activated protein kinase kinase 3-like; K04432 mitogen-activated protein kinase kinase 3 [EC:2.7.12.2] [KO:K04432] [EC:2.7.12.2]
454515	MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
468310	MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
455065	MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
743199	MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
450161	MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
462644	MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
747077	MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
450445	MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
461358	MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
462336	MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
456893	JUN; jun proto-oncogene [KO:K04448]
453047	FOS; FBJ murine osteosarcoma viral oncogene homolog [KO:K04379]
494186	TNF; tumor necrosis factor [KO:K03156]
450200	IL1B; interleukin 1, beta [KO:K04519]
463288	IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
460816	IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [KO:K05406]
471723	IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [KO:K05425]
471205	IL8; interleukin 8 [KO:K10030]
747004	CCL5; chemokine (C-C motif) ligand 5 [KO:K12499]
749913	c-C motif chemokine 3-like 1-like; K05408 C-C motif chemokine 3 [KO:K05408]
454592	CCL3; chemokine (C-C motif) ligand 3 [KO:K05408]
454593	CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
455004	CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
100500706	TICAM2; toll-like receptor adaptor molecule 2 [KO:K05409]
468677	TICAM1; toll-like receptor adaptor molecule 1 [KO:K05842]
462397	RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
472512	IRF5; interferon regulatory factor 5 [KO:K09446]
450927	IRF7; interferon regulatory factor 7 [KO:K09447]
461366	SPP1; secreted phosphoprotein 1 [KO:K06250]
742813	IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon [KO:K07211] [EC:2.7.11.10]
452047	TBK1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
453178	TRAF3; TNF receptor-associated factor 3 [KO:K03174]
747565	IRF3; interferon regulatory factor 3 [KO:K05411]
100615583	CD40; CD40 molecule, TNF receptor superfamily member 5 [KO:K03160]
470892	CD80; CD80 molecule [KO:K05412]
470900	CD86; CD86 molecule [KO:K05413]
473185	IFNA21; interferon, alpha 21 [KO:K05414]
473193	IFNA14; interferon, alpha 14 [KO:K05414]
473196	IFNA6; interferon, alpha 6 [KO:K05414]
473198	IFNA2; interferon, alpha 2 [KO:K05414]
473199	IFNA8; interferon, alpha 8 [KO:K05414]
741890	IFNA4; interferon, alpha 4 [KO:K05414]
741660	IFNA17; interferon, alpha 17 [KO:K05414]
473195	IFNA5; interferon, alpha 5 [KO:K05414]
741747	IFNA7; interferon, alpha 7 [KO:K05414]
742651	IFNA13; interferon, alpha 13 [KO:K05414]
741978	IFNA16; interferon, alpha 16 [KO:K05414]
744748	IFNA4; interferon, alpha 4 [KO:K05414]
473191	interferon alpha-17-like; K05414 interferon alpha [KO:K05414]
473183	IFNB1; interferon, beta 1, fibroblast [KO:K05415]
458516	IFNAR1; interferon (alpha, beta and omega) receptor 1 [KO:K05130]
473965	IFNAR2; interferon (alpha, beta and omega) receptor 2 [KO:K05131]
459834	STAT1; signal transducer and activator of transcription 1, 91kDa [KO:K11220]
461242	CXCL10; chemokine (C-X-C motif) ligand 10 [KO:K12671]
471200	CXCL9; chemokine (C-X-C motif) ligand 9 [KO:K05416]
739195	CXCL11; chemokine (C-X-C motif) ligand 11 [KO:K12672]

Reference

PMID:17275323

Authors

Kawai T, Akira S.

Title

TLR signaling.

Journal

Semin Immunol 19:24-32 (2007)

Reference

PMID:17457343

Authors

O'Neill LA, Bowie AG.

Title

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.

Journal

Nat Rev Immunol 7:353-64 (2007)

Reference

PMID:16932750

Authors

Honda K, Taniguchi T.

Title

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.

Journal

Nat Rev Immunol 6:644-58 (2006)

Reference

PMID:17395581

Authors

Uematsu S, Akira S.

Title

Toll-like receptors and Type I interferons.

Journal

J Biol Chem 282:15319-23 (2007)

Reference

PMID:16497588

Authors

Akira S, Uematsu S, Takeuchi O.

Title

Pathogen recognition and innate immunity.

Journal

Cell 124:783-801 (2006)

Reference

PMID:14698224

Authors

Yamamoto M, Takeda K, Akira S.

Title

TIR domain-containing adaptors define the specificity of TLR signaling.

Journal

Mol Immunol 40:861-8 (2004)

Reference

Authors

Matsumoto M, Oshiumi H, Seya T.

Title

[TICAM-1, an adaptor molecule that participates in Toll-like receptor-mediated type1 interferon production.] (In Japanese)

Journal

Molecular Medicine 40:194-200 (2003)

Reference

PMID:12734364

Authors

Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.

Title

The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.

Journal

J Immunol 170:5165-75 (2003)

Reference

PMID:14751764

Authors

Aderem A, Smith KD.

Title

A systems approach to dissecting immunity and inflammation.

Journal

Semin Immunol 16:55-67 (2004)

Reference

PMID:17637696

Authors

Banerjee A, Gerondakis S.

Title

Coordinating TLR-activated signaling pathways in cells of the immune system.

Journal

Immunol Cell Biol : (2007)

Reference

PMID:17507094

Authors

Loniewski KJ, Patial S, Parameswaran N.

Title

Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.

Journal

Mol Immunol 44:3715-23 (2007)

Reference

PMID:11101877

Authors

Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.

Title

Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.

Journal

Nat Immunol 1:533-40 (2000)

Reference

PMID:16924467

Authors

Uematsu S, Akira S.

Title

Toll-like receptors and innate immunity.

Journal

J Mol Med 84:712-25 (2006)

KO pathway

ko04620

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Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (105)   
   KEGG GENES (105)   
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