KEGG   PATHWAY: ptr05132Help
Entry
ptr05132                    Pathway                                

Name
Salmonella infection - Pan troglodytes (chimpanzee)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Salmonella infection
ptr05132

All organismsOrtholog table
Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
462118  
CD14; CD14 molecule [KO:K04391]
743242  
TLR4; toll-like receptor 4 [KO:K10160]
458239  
LBP; lipopolysaccharide binding protein [KO:K05399]
460269  
MYD88; myeloid differentiation primary response gene (88) [KO:K04729]
457762  
TLR5; toll-like receptor 5 [KO:K10168]
459135  
NLRC4; NLR family, CARD domain containing 4 [KO:K12805]
742444  
PYCARD; PYD and CARD domain containing [KO:K12799]
451519  
CASP1; caspase 1, apoptosis-related cysteine peptidase [KO:K01370] [EC:3.4.22.36]
caspase-1-like; K01370 caspase 1 [EC:3.4.22.36] [KO:K01370] [EC:3.4.22.36]
741907  
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
745248  
CDC42; cell division cycle 42 [KO:K04393]
456609  
CDC42; cell division cycle 42 (GTP binding protein, 25kDa) [KO:K04393]
450161  
MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
462644  
MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
747077  
MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
454037  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
458680  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
450445  
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
461358  
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
462336  
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
453047  
FOS; FBJ murine osteosarcoma viral oncogene homolog [KO:K04379]
456893  
JUN; jun proto-oncogene [KO:K04448]
461406  
NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
466665  
RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
739011  
IL18; interleukin 18 (interferon-gamma-inducing factor) [KO:K05482]
450200  
IL1B; interleukin 1, beta [KO:K04519]
470485  
IL1A; interleukin 1, alpha [KO:K04383]
463288  
IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
471205  
IL8; interleukin 8 [KO:K10030]
749913  
c-C motif chemokine 3-like 1-like; K05408 C-C motif chemokine 3 [KO:K05408]
454592  
CCL3; chemokine (C-C motif) ligand 3 [KO:K05408]
454593  
CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
455004  
CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
461255  
CXCL3; chemokine (C-X-C motif) ligand 3 [KO:K05505]
740176  
CXCL2; chemokine (C-X-C motif) ligand 2 [KO:K05505]
740567  
CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [KO:K05505]
471627  
CSF2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
462935  
WASF1; WAS protein family, member 1 [KO:K05753]
456675  
WASF2; WAS protein family, member 2 [KO:K05748]
463688  
WASL; Wiskott-Aldrich syndrome-like [KO:K05747]
464728  
ARPC5L; actin related protein 2/3 complex, subunit 5-like [KO:K05754]
457574  
ARPC5; actin related protein 2/3 complex, subunit 5, 16kDa [KO:K05754]
739553  
actin-related protein 2/3 complex subunit 5-like protein-like; K05754 actin related protein 2/3 complex, subunit 5 [KO:K05754]
ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa [KO:K05755]
744058  
actin-related protein 2/3 complex subunit 3-like; K05756 actin related protein 2/3 complex, subunit 3 [KO:K05756]
737048  
ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa [KO:K05756]
463568  
ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa [KO:K05757]
737235  
ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa [KO:K05757]
459938  
ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa [KO:K05758]
453253  
TJP1; tight junction protein 1 [KO:K05701]
450133  
ACTB; actin, beta [KO:K05692]
744996  
actin; K05692 actin beta/gamma 1 [KO:K05692]
746570  
ACTG1; actin, gamma 1 [KO:K05692]
456998  
PKN2; protein kinase N2 [KO:K06071] [EC:2.7.11.13]
455785  
PKN1; protein kinase N1 [KO:K06071] [EC:2.7.11.13]
464773  
PKN3; protein kinase N3 [KO:K06071] [EC:2.7.11.13]
455326  
ROCK1; Rho-associated, coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
470307  
ROCK2; Rho-associated, coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
456462  
PLEKHM2; pleckstrin homology domain containing, family M (with RUN domain) member 2 [KO:K15348]
466670  
KLC2; kinesin light chain 2 [KO:K10407]
468918  
KLC3; kinesin light chain 3 [KO:K10407]
735843  
KLC4; kinesin light chain 4 [KO:K10407]
453188  
KLC1; kinesin light chain 1 [KO:K10407]
470919  
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
473242  
RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
750412  
RILP; Rab interacting lysosomal protein [KO:K13883]
453171  
DYNC1H1; dynein, cytoplasmic 1, heavy chain 1 [KO:K10413]
451515  
DYNC2H1; dynein, cytoplasmic 2, heavy chain 1 [KO:K10414]
450134  
DNCI1; dynein, cytoplasmic 1, intermediate chain 1 [KO:K10415]
737197  
DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2 [KO:K10415]
460251  
DYNC1LI1; dynein, cytoplasmic 1, light intermediate chain 1 [KO:K10416]
740409  
DYNC1LI2; dynein, cytoplasmic 1, light intermediate chain 2 [KO:K10416]
471759  
PFN3; profilin 3 [KO:K05759]
460989  
PFN2; profilin 2 [KO:K05759]
748477  
PFN1; profilin 1 [KO:K05759]
PFN4; profilin family, member 4 [KO:K05759]
profilin-1-like; K05759 profilin [KO:K05759]
737948  
PDE4DIP; phosphodiesterase 4D interacting protein [KO:K05759]
460476  
FLNB; filamin B, beta [KO:K04437]
463711  
FLNC; filamin C, gamma [KO:K04437]
449517  
IFNG; interferon, gamma [KO:K04687]
747276  
IFNGR1; interferon gamma receptor 1 [KO:K05132]
470077  
IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1) [KO:K05133]
455026  
NOS2; nitric oxide synthase 2, inducible [KO:K13241] [EC:1.14.13.39]
Compound
C00062  
L-Arginine
C00338  
Lipopolysaccharide
C00533  
Nitric oxide
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Reference
  Authors
Trebichavsky I, Splichal I, Splichalova A
  Title
Innate immune response in the gut against Salmonella - review.
  Journal
Folia Microbiol (Praha) 55:295-300 (2010)
Reference
  Authors
Talbot S, Totemeyer S, Yamamoto M, Akira S, Hughes K, Gray D, Barr T, Mastroeni P, Maskell DJ, Bryant CE
  Title
Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella  enterica serovar typhimurium infection, but not for the initiation of bacterial clearance.
  Journal
Immunology 128:472-83 (2009)
Reference
  Authors
Ibarra JA, Steele-Mortimer O
  Title
Salmonella--the ultimate insider. Salmonella virulence factors that modulate intracellular survival.
  Journal
Cell Microbiol 11:1579-86 (2009)
Reference
  Authors
Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL
  Title
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression.
  Journal
J Immunol 167:1882-5 (2001)
Reference
  Authors
Vijay-Kumar M, Wu H, Jones R, Grant G, Babbin B, King TP, Kelly D, Gewirtz AT, Neish AS
  Title
Flagellin suppresses epithelial apoptosis and limits disease during enteric infection.
  Journal
Am J Pathol 169:1686-700 (2006)
Reference
  Authors
Miao EA, Andersen-Nissen E, Warren SE, Aderem A
  Title
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system.
  Journal
Semin Immunopathol 29:275-88 (2007)
Reference
  Authors
Bueno SM, Riedel CA, Carreno LJ, Kalergis AM
  Title
Virulence mechanisms displayed by Salmonella to impair dendritic cell function.
  Journal
Curr Med Chem 17:1156-66 (2010)
Reference
  Authors
Haraga A, Ohlson MB, Miller SI
  Title
Salmonellae interplay with host cells.
  Journal
Nat Rev Microbiol 6:53-66 (2008)
Reference
  Authors
Kimbrough TG, Miller SI
  Title
Assembly of the type III secretion needle complex of Salmonella typhimurium.
  Journal
Microbes Infect 4:75-82 (2002)
Reference
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
Reference
  Authors
Bulgin R, Raymond B, Garnett JA, Frankel G, Crepin VF, Berger CN, Arbeloa A
  Title
Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors.
  Journal
Infect Immun 78:1417-25 (2010)
Reference
  Authors
Bakowski MA, Braun V, Brumell JH
  Title
Salmonella-containing vacuoles: directing traffic and nesting to grow.
  Journal
Traffic 9:2022-31 (2008)
Reference
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
Reference
  Authors
Nikolaus T, Deiwick J, Rappl C, Freeman JA, Schroder W, Miller SI, Hensel M
  Title
SseBCD proteins are secreted by the type III secretion system of Salmonella pathogenicity island 2 and function as a translocon.
  Journal
J Bacteriol 183:6036-45 (2001)
Reference
  Authors
Eckmann L, Kagnoff MF
  Title
Cytokines in host defense against Salmonella.
  Journal
Microbes Infect 3:1191-200 (2001)
Reference
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
Reference
  Authors
Du F, Galan JE
  Title
Selective inhibition of type III secretion activated signaling by the Salmonella  effector AvrA.
  Journal
PLoS Pathog 5:e1000595 (2009)
Reference
  Authors
Jones RM, Wu H, Wentworth C, Luo L, Collier-Hyams L, Neish AS
  Title
Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade.
  Journal
Cell Host Microbe 3:233-44 (2008)
Reference
  Authors
Haraga A, Miller SI
  Title
A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1.
  Journal
Cell Microbiol 8:837-46 (2006)
Reference
  Authors
Abrahams GL, Muller P, Hensel M
  Title
Functional dissection of SseF, a type III effector protein involved in positioning the salmonella-containing vacuole.
  Journal
Traffic 7:950-65 (2006)
Reference
  Authors
Henry T, Couillault C, Rockenfeller P, Boucrot E, Dumont A, Schroeder N, Hermant A, Knodler LA, Lecine P, Steele-Mortimer O, Borg JP, Gorvel JP, Meresse S
  Title
The Salmonella effector protein PipB2 is a linker for kinesin-1.
  Journal
Proc Natl Acad Sci U S A 103:13497-502 (2006)
Reference
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the  actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
Reference
  Authors
Prior K, Hautefort I, Hinton JC, Richardson DJ, Rowley G
  Title
All stressed out. Salmonella pathogenesis and reactive nitrogen species.
  Journal
Adv Microb Physiol 56:1-28 (2009)
KO pathway
 

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