KEGG   PATHWAY: ptr05166Help
Entry
ptr05166                    Pathway                                

Name
HTLV-I infection - Pan troglodytes (chimpanzee)
Description
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
HTLV-I infection
ptr05166

All organismsOrtholog table
Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
456060  
TGFB1; transforming growth factor, beta 1 [KO:K13375]
457742  
TGFB2; transforming growth factor, beta 2 [KO:K13376]
453054  
TGFB3; transforming growth factor, beta 3 [KO:K13377]
SLC2A1; solute carrier family 2 (facilitated glucose transporter), member 1 [KO:K07299]
450397  
NRP1; neuropilin 1 [KO:K06724]
457059  
VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
451584  
CD3D; CD3d molecule, delta (CD3-TCR complex) [KO:K06450]
742330  
CD3E; CD3e molecule, epsilon (CD3-TCR complex) [KO:K06451]
451585  
CD3G; CD3g molecule, gamma (CD3-TCR complex) [KO:K06452]
450196  
ICAM1; intercellular adhesion molecule 1 [KO:K06490]
454045  
ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1 [KO:K05718]
458607  
ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
453494  
TLN2; talin 2 [KO:K06271]
465080  
TLN1; talin 1 [KO:K06271]
464393  
MYC; v-myc myelocytomatosis viral oncogene homolog (avian) [KO:K04377]
463564  
TRRAP; transformation/transcription domain-associated protein [KO:K08874]
451329  
KAT5; K(lysine) acetyltransferase 5 [KO:K11304] [EC:2.3.1.48]
747123  
CCND2; cyclin D2 [KO:K10151]
739886  
RANBP3; RAN binding protein 3 [KO:K15304]
452414  
RAN; RAN, member RAS oncogene family [KO:K07936]
459534  
XPO1; exportin 1 (CRM1 homolog, yeast) [KO:K14290]
450202  
PATR-B; major histocompatibility complex, class I, B [KO:K06751]
471962  
PATR-C; major histocompatibility complex, class I, C [KO:K06751]
462540  
PATR-E; major histocompatibility complex, class I, E [KO:K06751]
494187  
PATR-G; MHC class Ib [KO:K06751]
450151  
PATR-A; major histocompatibility complex, class I, A [KO:K06751]
749652  
patr class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
463178  
PATR-AL; major histocompatibility complex, class I, AL [KO:K06751]
PATR-F; major histocompatibility complex, class I, F [KO:K06751]
455756  
CALR; calreticulin [KO:K08057]
742406  
PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
461403  
PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
450898  
PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
736325  
PPP3R2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
PPP3R1; protein phosphatase 3, regulatory subunit B, alpha [KO:K06268]
455485  
NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [KO:K04446]
469972  
NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [KO:K17332]
454184  
NFATC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 [KO:K17333]
452821  
NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 [KO:K17334]
462330  
CANX; calnexin [KO:K08054]
470203  
IL2RB; interleukin 2 receptor, beta [KO:K05069]
465692  
CXHXorf65; interleukin 2 receptor, gamma [KO:K05070]
cytokine receptor common subunit gamma-like; K05070 interleukin 2 receptor gamma [KO:K05070]
743373  
JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
455848  
JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
454681  
STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
454679  
STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
457366  
FDPS; farnesyl diphosphate synthase [KO:K00787] [EC:2.5.1.10 2.5.1.1]
466302  
HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog [KO:K02833]
473387  
KRAS; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
742713  
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
468955  
RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
451038  
RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
470938  
MRAS; muscle RAS oncogene homolog [KO:K07831]
745717  
VDAC1; voltage-dependent anion channel 1 [KO:K05862]
461632  
SLC25A4; solute carrier family 25 (mitochondrial carrier [KO:K05863]
742937  
SLC25A31; solute carrier family 25 (mitochondrial carrier [KO:K05863]
738876  
VDAC2; voltage-dependent anion channel 2 [KO:K15040]
737891  
VDAC3; voltage-dependent anion channel 3 [KO:K15041]
458887  
TSPO; translocator protein (18kDa) [KO:K05770]
454220  
VAC14; Vac14 homolog (S. cerevisiae) [KO:K15305]
458661  
RANBP1; RAN binding protein 1 [KO:K15306]
461661  
MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast) [KO:K02537]
453324  
BUB1B; budding uninhibited by benzimidazoles 1 homolog beta (yeast) [KO:K06637] [EC:2.7.11.1]
450800  
BUB3; budding uninhibited by benzimidazoles 3 homolog (yeast) [KO:K02180]
456819  
CDC20; cell division cycle 20 homolog (S. cerevisiae) [KO:K03363]
459381  
ANAPC1; anaphase promoting complex subunit 1 [KO:K03348]
735949  
ANAPC1; anaphase promoting complex subunit 1 [KO:K03348]
465174  
ANAPC2; anaphase promoting complex subunit 2 [KO:K03349]
454815  
CDC27; cell division cycle 27 homolog (S. cerevisiae) [KO:K03350]
461149  
ANAPC4; anaphase promoting complex subunit 4 [KO:K03351]
452321  
ANAPC5; anaphase promoting complex subunit 5 [KO:K03352]
452688  
CDC16; cell division cycle 16 homolog (S. cerevisiae) [KO:K03353]
467128  
ANAPC7; anaphase promoting complex subunit 7 [KO:K03354]
462092  
CDC23; cell division cycle 23 homolog (S. cerevisiae) [KO:K03355]
739629  
ANAPC10; anaphase promoting complex subunit 10 [KO:K03357]
454972  
ANAPC11; anaphase promoting complex subunit 11 [KO:K03358]
473026  
CDC26; cell division cycle 26 homolog (S. cerevisiae) [KO:K03359]
462238  
PTTG1; pituitary tumor-transforming 1 [KO:K06635]
736475  
PTTG2; pituitary tumor-transforming 2 [KO:K06635]
747442  
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) [KO:K06625]
458081  
PCNA; proliferating cell nuclear antigen [KO:K04802]
456228  
POLD1; polymerase (DNA directed), delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
472654  
POLD2; polymerase (DNA directed), delta 2, accessory subunit [KO:K02328]
451422  
POLD3; polymerase (DNA-directed), delta 3, accessory subunit [KO:K03504]
451366  
POLD4; polymerase (DNA-directed), delta 4, accessory subunit [KO:K03505]
452384  
POLE; DNA polymerase epsilon catalytic subunit A-like [KO:K02324] [EC:2.7.7.7]
467165  
POLE; polymerase (DNA directed), epsilon [KO:K02324] [EC:2.7.7.7]
452888  
POLE2; polymerase (DNA directed), epsilon 2, accessory subunit [KO:K02325] [EC:2.7.7.7]
741748  
POLE3; polymerase (DNA directed), epsilon 3, accessory subunit [KO:K02326] [EC:2.7.7.7]
459343  
POLE4; polymerase (DNA-directed), epsilon 4, accessory subunit [KO:K03506] [EC:2.7.7.7]
747688  
CCND1; cyclin D1 [KO:K04503]
462689  
CCND3; cyclin D3 [KO:K10152]
452025  
CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
452715  
RB1; retinoblastoma 1 [KO:K06618]
458184  
E2F1; E2F transcription factor 1 [KO:K17454]
469153  
E2F2; E2F transcription factor 2 [KO:K09389]
471865  
E2F3; E2F transcription factor 3 [KO:K06620]
465021  
CDKN2A; cyclin-dependent kinase inhibitor 2A [KO:K06621]
473204  
CDKN2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [KO:K04685]
742674  
WNT1; wingless-type MMTV integration site family, member 1 [KO:K03209]
463673  
WNT2; wingless-type MMTV integration site family member 2 [KO:K00182]
457103  
WNT2B; wingless-type MMTV integration site family, member 2B [KO:K00182]
468297  
WNT3; wingless-type MMTV integration site family, member 3 [KO:K00312]
WNT3A; wingless-type MMTV integration site family, member 3A [KO:K00312]
469212  
WNT4; wingless-type MMTV integration site family, member 4 [KO:K00408]
467191  
WNT5B; wingless-type MMTV integration site family, member 5B [KO:K00444]
460458  
WNT5A; wingless-type MMTV integration site family, member 5A [KO:K00444]
742467  
WNT6; wingless-type MMTV integration site family, member 6 [KO:K00445]
465393  
WNT7B; wingless-type MMTV integration site family, member 7B [KO:K00572]
471645  
WNT8A; wingless-type MMTV integration site family, member 8A [KO:K00714]
466182  
WNT8B; wingless-type MMTV integration site family, member 8B [KO:K00714]
468296  
WNT9B; wingless-type MMTV integration site family, member 9B [KO:K01064]
469697  
WNT9A; wingless-type MMTV integration site family, member 9A [KO:K01064]
451870  
WNT10B; wingless-type MMTV integration site family, member 10B [KO:K01357]
459952  
WNT10A; wingless-type MMTV integration site family, member 10A [KO:K01357]
451431  
WNT11; wingless-type MMTV integration site family, member 11 [KO:K01384]
737375  
WNT16; wingless-type MMTV integration site family, member 16 [KO:K01558]
463524  
FZD1; frizzled family receptor 1 [KO:K02432]
459881  
FZD7; frizzled family receptor 7 [KO:K02432]
454731  
FZD2; frizzled family receptor 2 [KO:K02235]
472726  
FZD3; frizzled family receptor 3 [KO:K02329]
466732  
FZD4; frizzled family receptor 4 [KO:K02354]
470627  
FZD5; frizzled family receptor 5 [KO:K02375]
466040  
FZD8; frizzled family receptor 8 [KO:K02375]
464327  
FZD6; frizzled family receptor 6 [KO:K02376]
467160  
FZD10; frizzled family receptor 10 [KO:K02842]
472405  
FZD9; frizzled family receptor 9 [KO:K02842]
460882  
DVL3; dishevelled, dsh homolog 3 (Drosophila) [KO:K02353]
455236  
DVL2; dishevelled, dsh homolog 2 (Drosophila) [KO:K02353]
457191  
DVL1; dishevelled, dsh homolog 1 (Drosophila) [KO:K02353]
GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
450183  
CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa [KO:K02105]
461999  
APC; adenomatous polyposis coli [KO:K02085]
455551  
APC2; adenomatosis polyposis coli 2 [KO:K02085]
460968  
DLG1; discs, large homolog 1 (Drosophila) [KO:K12076]
740202  
PDGFA; platelet-derived growth factor alpha polypeptide [KO:K04359]
458844  
PDGFB; platelet-derived growth factor beta polypeptide [KO:K17386]
461318  
PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
462188  
PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
456565  
PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
461836  
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
455085  
PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
455855  
PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
463649  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
460858  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
457922  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
471079  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
456035  
AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
740898  
AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
494186  
TNF; tumor necrosis factor [KO:K03156]
466934  
TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A [KO:K03158]
471543  
MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [KO:K04416] [EC:2.7.11.25]
455065  
MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
456893  
JUN; jun proto-oncogene [KO:K04448]
455229  
GPS2; G protein pathway suppressor 2 [KO:K15307]
459460  
IL1R1; interleukin 1 receptor, type I [KO:K04386]
470455  
IL1R2; interleukin 1 receptor, type II [KO:K04387]
743494  
T-cell receptor alpha chain V region RL-5-like; K10784 T cell receptor alpha chain V region [KO:K10784]
BV7-9; uncharacterized LOC100615597 [KO:K10785]
BV10-1; uncharacterized LOC100613861 [KO:K10785]
T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
742771  
T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
468286  
MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
450673  
CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
472749  
IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
NF-kappa-B essential modulator-like; K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma [KO:K07210]
467426  
NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
461406  
NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
466665  
RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
451778  
LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3) [KO:K03159]
CD40; CD40 molecule, TNF receptor superfamily member 5 [KO:K03160]
746611  
TNFRSF13C; tumor necrosis factor receptor superfamily, member 13C [KO:K05151]
454750  
MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
456119  
RELB; v-rel reticuloendotheliosis viral oncogene homolog B [KO:K09253]
450697  
NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) [KO:K04469]
461472  
IL2; interleukin 2 [KO:K05429]
450884  
IL2RA; interleukin 2 receptor, alpha [KO:K05068]
737808  
IL15; interleukin 15 [KO:K05433]
738192  
IL15RA; interleukin 15 receptor, alpha [KO:K05074]
463288  
IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
471627  
CSF2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
494185  
LTA; lymphotoxin alpha (TNF superfamily, member 1) [KO:K05468]
458156  
BCL2L1; BCL2-like 1 [KO:K04570]
473765  
XIAP; X-linked inhibitor of apoptosis [KO:K04725]
736203  
ZFP36; zinc finger protein 36, C3H type, homolog (mouse) [KO:K15308]
452191  
NFYB; nuclear transcription factor Y, beta [KO:K08065]
449592  
PATR-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
471974  
PATR-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
471976  
PATR-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
471977  
PATR-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
471979  
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
462591  
PATR-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
462594  
PATR-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
462598  
PATR-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
462599  
PATR-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
462592  
PATR-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
MAMU-DMA; HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752]
462709  
SRF; serum response factor (c-fos serum response element-binding transcription factor) [KO:K04378]
742304  
ELK4; ELK4, ETS-domain protein (SRF accessory protein 1) [KO:K04376]
473591  
ELK1; ELK1, member of ETS oncogene family [KO:K04375]
451169  
SPI1; spleen focus forming virus (SFFV) proviral integration oncogene spi1 [KO:K09438]
473996  
ETS2; v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) [KO:K02678]
451695  
transforming protein p68/c-ets-1-like; K02678 c-ets proto-oncogene protein [KO:K02678]
463010  
TBPL1; TBP-like 1 [KO:K03120]
452923  
TBPL2; TATA box binding protein like 2 [KO:K03120]
738472  
TBP; TATA box binding protein [KO:K03120]
453047  
FOS; FBJ murine osteosarcoma viral oncogene homolog [KO:K04379]
462097  
EGR1; early growth response 1 [KO:K09203]
745846  
EGR2; early growth response 2 [KO:K12496]
745919  
FOSL1; FOS-like antigen 1 [KO:K04502]
463392  
ADCY1; adenylate cyclase 1 (brain) [KO:K08041] [EC:4.6.1.1]
461715  
ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
459070  
ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
452819  
ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
470905  
ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
451866  
ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
473278  
ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
464400  
ADCY8; adenylate cyclase 8 (brain) [KO:K08048] [EC:4.6.1.1]
adenylate cyclase type 8-like; K08048 adenylate cyclase 8 [EC:4.6.1.1] [KO:K08048] [EC:4.6.1.1]
453869  
ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
469367  
PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
472944  
PRKACG; protein kinase, cAMP-dependent, catalytic, gamma [KO:K04345] [EC:2.7.11.11]
449495  
PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
455776  
PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
751063  
cAMP-dependent protein kinase catalytic subunit PRKX-like; K04345 protein kinase A [EC:2.7.11.11] [KO:K04345] [EC:2.7.11.11]
459901  
CREB1; cAMP responsive element binding protein 1 [KO:K05870]
450400  
CREM; cAMP responsive element modulator [KO:K09052]
452429  
ATF1; activating transcription factor 1 [KO:K09053]
739083  
ATF2; activating transcription factor 2 [KO:K04450]
ATF2; activating transcription factor 2 [KO:K04450]
469143  
ATF3; activating transcription factor 3 [KO:K09032]
744513  
ATF4; activating transcription factor 4 (tax-responsive enhancer element B67) [KO:K04374]
458735  
XBP1; X-box binding protein 1 [KO:K09027]
735806  
CRTC1; CREB regulated transcription coactivator 1 [KO:K15309]
738694  
CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
453648  
CRTC3; CREB regulated transcription coactivator 3 [KO:K16334]
467891  
CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
458862  
EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
460219  
KAT2B; K(lysine) acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]
454677  
KAT2A; K(lysine) acetyltransferase 2A [KO:K06062] [EC:2.3.1.48]
468650  
TCF3; transcription factor 7-like 1 (T-cell specific, HMG-box) [KO:K09063]
737210  
POLB; polymerase (DNA directed), beta [KO:K02330] [EC:4.2.99.- 2.7.7.7]
469319  
CDKN2C; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) [KO:K06622]
456715  
LCK; lymphocyte-specific protein tyrosine kinase [KO:K05856] [EC:2.7.10.2]
TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
463016  
MYB; v-myb myeloblastosis viral oncogene homolog (avian) [KO:K09420]
747811  
MYBL1; v-myb myeloblastosis viral oncogene homolog (avian)-like 1 [KO:K09421]
458262  
MYBL2; v-myb myeloblastosis viral oncogene homolog (avian)-like 2 [KO:K09421]
472992  
TGFBR1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
460243  
TGFBR2; transforming growth factor, beta receptor II (70/80kDa) [KO:K04388] [EC:2.7.11.30]
455407  
SMAD2; SMAD family member 2 [KO:K04500]
748161  
SMAD3; SMAD family member 3 [KO:K04500]
468537  
SMAD4; SMAD family member 4 [KO:K04501]
451530  
ATM; ataxia telangiectasia mutated [KO:K04728] [EC:2.7.11.1]
460745  
ATR; ataxia telangiectasia and Rad3 related [KO:K06640] [EC:2.7.11.1]
739836  
CHEK1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
458733  
CHEK2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
455214  
TP53; tumor protein p53 [KO:K04451]
747093  
BAX; BCL2-associated X protein [KO:K02159]
739304  
TP53INP1; tumor protein p53 inducible nuclear protein 1 [KO:K15310]
461092  
MSX1; msh homeobox 1 [KO:K09341]
744194  
MSX2; msh homeobox 2 [KO:K09341]
453478  
CCNB2; cyclin B2 [KO:K05868]
Compound
C00027  
Hydrogen peroxide
C00076  
Calcium cation
C00238  
Potassium cation
C00575  
3',5'-Cyclic AMP
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C18994  
Accessory protein p12I
C18995  
P13 protein
C18996  
Accessory protein p30II
C19313  
HTLV-1 basic zipper factor
Reference
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
Reference
  Authors
Gatza ML, Watt JC, Marriott SJ
  Title
Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades.
  Journal
Oncogene 22:5141-9 (2003)
Reference
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
Reference
  Authors
Boxus M, Willems L
  Title
Mechanisms of HTLV-1 persistence and transformation.
  Journal
Br J Cancer 101:1497-501 (2009)
Reference
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
Reference
  Authors
Yasunaga J, Matsuoka M
  Title
[HTLV-I and leukemogenesis].
  Journal
Uirusu 56:241-9 (2006)
Reference
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
Reference
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
Reference
  Authors
Peloponese JM Jr, Jeang KT
  Title
Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein.
  Journal
J Biol Chem 281:8927-38 (2006)
Reference
  Authors
Marriott SJ, Semmes OJ
  Title
Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response.
  Journal
Oncogene 24:5986-95 (2005)
Reference
  Authors
Jeang KT
  Title
Functional activities of the human T-cell leukemia virus type I Tax oncoprotein:  cellular signaling through NF-kappa B.
  Journal
Cytokine Growth Factor Rev 12:207-17 (2001)
Reference
  Authors
Bouzar AB, Willems L
  Title
How HTLV-1 may subvert miRNAs for persistence and transformation.
  Journal
Retrovirology 5:101 (2008)
Reference
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
Reference
  Authors
Manel N, Battini JL, Taylor N, Sitbon M
  Title
HTLV-1 tropism and envelope receptor.
  Journal
Oncogene 24:6016-25 (2005)
Reference
  Authors
Sun SC, Ballard DW
  Title
Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases.
  Journal
Oncogene 18:6948-58 (1999)
Reference
  Authors
Taylor GP, Matsuoka M
  Title
Natural history of adult T-cell leukemia/lymphoma and approaches to therapy.
  Journal
Oncogene 24:6047-57 (2005)
Reference
  Authors
Franchini G, Fukumoto R, Fullen JR
  Title
T-cell control by human T-cell leukemia/lymphoma virus type 1.
  Journal
Int J Hematol 78:280-96 (2003)
Reference
  Authors
Baydoun HH, Bellon M, Nicot C
  Title
HTLV-1 Yin and Yang: Rex and p30 master regulators of viral mRNA trafficking.
  Journal
AIDS Rev 10:195-204 (2008)
Reference
PMID:9325311
  Authors
Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS, Jeang KT
  Title
A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha.
  Journal
J Biol Chem 272:25816-23 (1997)
Reference
  Authors
Pise-Masison CA, Brady JN
  Title
Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function.
  Journal
Front Biosci 10:919-30 (2005)
KO pathway
 

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