KEGG   PATHWAY: pub03440Help
Entry
pub03440                    Pathway                                

Name
Homologous recombination - Candidatus Pelagibacter ubique
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
pub03440  Homologous recombination
pub03440

Ortholog table
Module
pub_M00260  DNA polymerase III complex, bacteria [PATH:pub03440]
Other DBs
BSID: 25000
GO: 0000724
Organism
Candidatus Pelagibacter ubique [GN:pub]
Gene
SAR11_1010  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
SAR11_0984  ssb; single-strand binding protein (ssb) [KO:K03111]
SAR11_1052  recO; Recombination protein O [KO:K03584]
SAR11_0509  recR; recR-like protein [KO:K06187]
SAR11_0641  recA; recA protein [KO:K03553]
SAR11_0200  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SAR11_0593  ruvC; crossover junction endodeoxyribonuclease [KO:K01159] [EC:3.1.22.4]
SAR11_0993  recG; ATP-dependent DNA helicase recG [KO:K03655] [EC:3.6.4.12]
SAR11_0906  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
SAR11_0411  dnaN; DNA polymerase III [KO:K02338] [EC:2.7.7.7]
SAR11_0507  dnaX; DNA-directed DNA polymerase gamma/tau subunit [KO:K02343] [EC:2.7.7.7]
SAR11_0355  holA; DNA-directed DNA polymerase III [KO:K02340] [EC:2.7.7.7]
SAR11_1000  holB; probable DNA polymerase III [KO:K02341] [EC:2.7.7.7]
SAR11_0339  dnaQ; DNA polymerase III [KO:K02342] [EC:2.7.7.7]
SAR11_0234  priA; probable primosomal protein N [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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