KEGG   PATHWAY: rba03410Help
Entry
rba03410                    Pathway                                

Name
Base excision repair - Rhodopirellula baltica
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Base excision repair
rba03410

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Other DBs
Organism
Rhodopirellula baltica [GN:rba]
Gene
RB7569  
mutM; formamidopyrimidine-DNA glycosylase [KO:K10563] [EC:4.2.99.18 3.2.2.23]
mutM; formamidopyrimidine-DNA glycosylase [KO:K05522] [EC:4.2.99.18 3.2.2.-]
RB5097  
endonuclease III; K10773 endonuclease III [EC:4.2.99.18] [KO:K10773] [EC:4.2.99.18]
RB4998  
alkA; DNA-3-methyladenine glycosidase [KO:K01247] [EC:3.2.2.21]
RB5226  
tag; DNA-3-methyladenine glycosylase I [KO:K01246] [EC:3.2.2.20]
smuG1; single-strand selective monofunctional uracil DNA glycosylase [KO:K10800] [EC:3.2.2.-]
RB301  
mutY; A/G-specific adenine glycosylase [KO:K03575] [EC:3.2.2.-]
RB8205  
mpg; N-methylpurine-DNA glycosirase (MPG) [KO:K03652] [EC:3.2.2.21]
RB8161  
exoA; exodeoxyribonuclease [KO:K01142] [EC:3.1.11.2]
polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
RB8726  
recJ; single-strand DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
RB1571  
dnlI; ATP-dependent DNA ligase [KO:K01971] [EC:6.5.1.1]
ligA; DNA ligase [KO:K01972] [EC:6.5.1.2]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
 

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