KEGG   PATHWAY: rcu00600
Entry
rcu00600                    Pathway                                
Name
Sphingolipid metabolism - Ricinus communis (castor bean)
Class
Metabolism; Lipid metabolism
Pathway map
rcu00600  Sphingolipid metabolism
rcu00600

Module
rcu_M00100  Sphingosine degradation [PATH:rcu00600]
Other DBs
GO: 0006665
Organism
Ricinus communis (castor bean) [GN:rcu]
Gene
8285274  long chain base biosynthesis protein 2a isoform X1 [KO:K00654] [EC:2.3.1.50]
8285010  long chain base biosynthesis protein 1 isoform X1 [KO:K00654] [EC:2.3.1.50]
8271593  3-dehydrosphinganine reductase TSC10A [KO:K04708] [EC:1.1.1.102]
8267872  LOW QUALITY PROTEIN: neutral ceramidase 2 [KO:K12349] [EC:3.5.1.23]
8279786  neutral ceramidase 1 [KO:K12349] [EC:3.5.1.23]
8273449  neutral ceramidase 2 [KO:K12349] [EC:3.5.1.23]
8277947  alkaline ceramidase [KO:K04711] [EC:3.5.1.-]
8280625  alkaline ceramidase [KO:K04711] [EC:3.5.1.-]
8279484  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
8260622  sphinganine C4-monooxygenase 1 [KO:K04713] [EC:1.14.18.5]
8281414  very-long-chain aldehyde decarbonylase GL1-9 [KO:K04713] [EC:1.14.18.5]
8289641  ceramide kinase [KO:K04715] [EC:2.7.1.138]
8289825  sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
8286769  sphingosine-1-phosphate lyase [KO:K01634] [EC:4.1.2.27]
8280687  non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
8277184  non-lysosomal glucosylceramidase isoform X1 [KO:K17108] [EC:3.2.1.45]
8288684  non-lysosomal glucosylceramidase isoform X2 [KO:K17108] [EC:3.2.1.45]
8270882  beta-galactosidase isoform X1 [KO:K01190] [EC:3.2.1.23]
8288580  beta-galactosidase 17 [KO:K12309] [EC:3.2.1.23]
8260752  alpha-galactosidase 1 isoform X2 [KO:K07407] [EC:3.2.1.22]
8260754  alpha-galactosidase 1 isoform X1 [KO:K07407] [EC:3.2.1.22]
8286475  alpha-galactosidase [KO:K07407] [EC:3.2.1.22]
8260757  alpha-galactosidase 1 [KO:K07407] [EC:3.2.1.22]
8278538  alpha-galactosidase [KO:K07407] [EC:3.2.1.22]
8259536  alpha-galactosidase 3 isoform X1 [KO:K07407] [EC:3.2.1.22]
8263447  beta-hexosaminidase 3 [KO:K12373] [EC:3.2.1.52]
8273561  beta-hexosaminidase 2 [KO:K12373] [EC:3.2.1.52]
8272227  beta-hexosaminidase 1 [KO:K12373] [EC:3.2.1.52]
8277678  prosaposin [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
rcu00260  Glycine, serine and threonine metabolism
rcu00601  Glycosphingolipid biosynthesis - lacto and neolacto series
rcu00603  Glycosphingolipid biosynthesis - globo and isoglobo series
rcu00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (29)   
   KEGG GENES (29)   
All databases (30)   

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