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reh03440                    Pathway                                

Homologous recombination - Ralstonia eutropha H16
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Genetic Information Processing; Replication and repair
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Homologous recombination

All organismsOrtholog table
DNA polymerase III complex, bacteria [PATH:reh03440]
Other DBs
Ralstonia eutropha H16 [GN:reh]
cJ; Single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
h16_A0402; Single-strand binding protein [KO:K03111]
ssb; putative single-strand binding protein [KO:K03111]
cO; combinational DNA repair protein (RecF pathway) [KO:K03584]
cR; Recombinational DNA repair protein (RecF pathway) [KO:K06187]
cA; Recobination protein RecA [KO:K03553]
polA; DNA polymerase I [KO:K02335] [EC:]
ruvA; holliday junction resolvasome, DNA-binding subunit RuvA [KO:K03550] [EC:]
ruvB; holliday junction resolvasome, helicase subunit RuvB [KO:K03551] [EC:]
ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:]
cG; ATP-dependent DNA helicase [KO:K03655] [EC:]
dnaE1; DNA polymerase III alpha subunit [KO:K02337] [EC:]
dnaN; DNA polymerase III beta subunit [KO:K02338] [EC:]
dnaX; DNA polymerase III tau/gamma subunit [KO:K02343] [EC:]
holA; DNA polymerase III delta subunit [KO:K02340] [EC:]
holB; DNA polymerase III delta prime subunit [KO:K02341] [EC:]
h16_B0768; Exconuclease [KO:K02342] [EC:]
dnaQ; DNA polymerase III epsilon subunit [KO:K02342] [EC:]
h16_B2389; putative exonuclease [KO:K02342] [EC:]
h16_A2430; hypothetical membrane associated protein,contains exonuclease domain [KO:K02342] [EC:]
holC; DNA polymerase III chi subunit [KO:K02339] [EC:]
priA; Primosomal protein N' [KO:K04066] [EC:3.6.4.-]
h16_A2278; primosomal replication protein N [KO:K02686]
Maloisel L, Fabre F, Gangloff S.
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Mol Cell Biol 28:1373-82 (2008)
Haruta-Takahashi N, Iwasaki H.
[Recombination mediators] Japanese
Seikagaku 79:449-53 (2007)
Ouyang KJ, Woo LL, Ellis NA.
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Mech Ageing Dev 129:425-40 (2008)
Kawabata M, Kawabata T, Nishibori M.
Role of recA/RAD51 family proteins in mammals.
Acta Med Okayama 59:1-9 (2005)
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Mitotic recombination in Saccharomyces cerevisiae.
Curr Genet 42:185-98 (2003)
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Rad54: the Swiss Army knife of homologous recombination?
Nucleic Acids Res 34:4115-25 (2006)
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Recombination proteins and rescue of arrested replication forks.
DNA Repair (Amst) 6:967-80 (2007)
KO pathway

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