KEGG   PATHWAY: reh03440Help
Entry
reh03440                    Pathway                                

Name
Homologous recombination - Ralstonia eutropha H16
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
reh03440  Homologous recombination
reh03440

Ortholog table
Module
reh_M00260  DNA polymerase III complex, bacteria [PATH:reh03440]
Other DBs
BSID: 40947
GO: 0000724
Organism
Ralstonia eutropha H16 [GN:reh]
Gene
H16_A1171  cJ; Single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
H16_A0402  h16_A0402; Single-strand binding protein [KO:K03111]
PHG335  ssb; putative single-strand binding protein [KO:K03111]
H16_A2553  cO; combinational DNA repair protein (RecF pathway) [KO:K03584]
H16_A2388  cR; Recombinational DNA repair protein (RecF pathway) [KO:K06187]
H16_A0544  cA; Recobination protein RecA [KO:K03553]
H16_A2741  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
H16_A0498  ruvA; holliday junction resolvasome, DNA-binding subunit RuvA [KO:K03550] [EC:3.6.4.12]
H16_A0497  ruvB; holliday junction resolvasome, helicase subunit RuvB [KO:K03551] [EC:3.6.4.12]
H16_A0500  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
H16_A3111  cG; ATP-dependent DNA helicase [KO:K03655] [EC:3.6.4.12]
H16_A0900  dnaE1; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
H16_A0002  dnaN; DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
H16_A2389  dnaX; DNA polymerase III tau/gamma subunit [KO:K02343] [EC:2.7.7.7]
H16_A3137  holA; DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
H16_A1570  holB; DNA polymerase III delta prime subunit [KO:K02341] [EC:2.7.7.7]
H16_B0768  h16_B0768; Exconuclease [KO:K02342] [EC:2.7.7.7]
H16_A2467  dnaQ; DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
H16_B2389  h16_B2389; putative exonuclease [KO:K02342] [EC:2.7.7.7]
H16_A2430  h16_A2430; hypothetical membrane associated protein,contains exonuclease domain [KO:K02342] [EC:2.7.7.7]
H16_A2989  holC; DNA polymerase III chi subunit [KO:K02339] [EC:2.7.7.7]
H16_A3632  priA; Primosomal protein N' [KO:K04066] [EC:3.6.4.-]
H16_A2278  h16_A2278; primosomal replication protein N [KO:K02686]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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