KEGG   PATHWAY: rer03440Help
Entry
rer03440                    Pathway                                

Name
Homologous recombination - Rhodococcus erythropolis PR4
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
rer03440  Homologous recombination
rer03440

Ortholog table
Module
rer_M00260  DNA polymerase III complex, bacteria [PATH:rer03440]
Other DBs
BSID: 95050
GO: 0000724
Organism
Rhodococcus erythropolis PR4 [GN:rer]
Gene
RER_58300  ssb; single-stranded DNA-binding protein [KO:K03111]
RER_38370  putative single-stranded DNA-binding protein [KO:K03111]
RER_00040  recF; DNA replication and repair protein RecF [KO:K03629]
RER_37130  recO; DNA repair protein RecO [KO:K03584]
RER_03910  recR; recombination protein RecR [KO:K06187]
RER_27530  recA; RecA protein [KO:K03553]
RER_33220  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
RER_52330  putative DNA polymerase [KO:K02335] [EC:2.7.7.7]
RER_29240  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
RER_29250  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
RER_29230  ruvC; Holliday junction endonuclease RuvC [KO:K01159] [EC:3.1.22.4]
RER_24240  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
RER_08580  recB; exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
RER_08570  recC; exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
RER_08590  recD; exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
RER_35310  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
RER_00020  dnaN; DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
RER_03760  dnaX; DNA polymerase III gamma/tau subunit [KO:K02343] [EC:2.7.7.7]
RER_37690  holA; putative DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
RER_05140  holB; putative DNA polymerase III delta' subunit [KO:K02341] [EC:2.7.7.7]
RER_49910  putative exonuclease [KO:K02342] [EC:2.7.7.7]
RER_35910  dnaQ; putative DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
RER_30120  priA; putative primosomal protein n' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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