KEGG   PATHWAY: reu03430
Entry
reu03430                    Pathway                                
Name
Mismatch repair - Cupriavidus pinatubonensis JMP134
Description
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Class
Genetic Information Processing; Replication and repair
Pathway map
reu03430  Mismatch repair
reu03430

Other DBs
GO: 0006298
Organism
Cupriavidus pinatubonensis JMP134 [GN:reu]
Gene
Reut_A1111  DNA mismatch repair protein MutS [KO:K03555]
Reut_A2769  DNA mismatch repair protein MutL [KO:K03572]
Reut_A0283  UvrD/REP helicase [KO:K03657] [EC:5.6.2.4]
Reut_A0864  ATP-dependent DNA helicase UvrD [KO:K03657] [EC:5.6.2.4]
Reut_C6151  hypothetical protein [KO:K03657] [EC:5.6.2.4]
Reut_A0596  Exodeoxyribonuclease VII large subunit [KO:K03601] [EC:3.1.11.6]
Reut_A0880  Exodeoxyribonuclease VII small subunit [KO:K03602] [EC:3.1.11.6]
Reut_A1074  exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Reut_A0369  single-strand binding protein [KO:K03111]
Reut_D6500  Single-strand binding protein [KO:K03111]
Reut_A2534  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Reut_A0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Reut_A2112  DNA polymerase III, gamma subunit / DNA polymerase III, tau subunit [KO:K02343] [EC:2.7.7.7]
Reut_A2832  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Reut_A1435  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
Reut_A2190  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Reut_B3616  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Reut_A2682  DNA polymerase III chi subunit, HolC [KO:K02339] [EC:2.7.7.7]
Reut_A1886  NAD-dependent DNA ligase [KO:K01972] [EC:6.5.1.2]
Reut_D6518  phage DNA methylase [KO:K06223] [EC:2.1.1.72]
Reference
  Authors
Jiricny J.
  Title
The multifaceted mismatch-repair system.
  Journal
Nat Rev Mol Cell Biol 7:335-46 (2006)
DOI:10.1038/nrm1907
Reference
  Authors
Li GM.
  Title
Mechanisms and functions of DNA mismatch repair.
  Journal
Cell Res 18:85-98 (2008)
DOI:10.1038/cr.2007.115
Reference
  Authors
Marti TM, Kunz C, Fleck O.
  Title
DNA mismatch repair and mutation avoidance pathways.
  Journal
J Cell Physiol 191:28-41 (2002)
DOI:10.1002/jcp.10077
Reference
  Authors
Ikejima M, Shimada T.
  Title
[Molecular mechanism of mismatch repair]
  Journal
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway
ko03430   

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