| Entry |
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| Name |
Homologous recombination - Rickettsia felis
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| Description |
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
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| Class |
Genetic Information Processing; Replication and repair
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| Pathway map |
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| Module |
| DNA polymerase III complex, bacteria [PATH: rfe03440] | | | | | | | | BRCA1-associated genome surveillance complex (BASC) [PATH: rfe03440] |
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| Other DBs |
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| Organism |
Rickettsia felis [GN: rfe]
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| Gene |
| recJ; single-stranded-DNA-specific exonuclease RecJ [KO: K07462] [EC:3.1.-.-] | | ssb; single-stranded DNA-binding protein [KO: K03111] | | recF; recombination protein F [KO: K03629] | | recO; DNA repair protein RecO [KO: K03584] | | recR; recombination protein RecR [KO: K06187] | | recA; recombinase A [KO: K03553] | | | | | | | | | | | | | | | | dnaX; DNA polymerase III subunits gamma and tau [KO: K02343] [EC: 2.7.7.7] | | | | | | dnaQ; DNA polymerase III subunit epsilon [KO: K02342] [EC: 2.7.7.7] | | DNA polymerase III subunit epsilon; K02342 DNA polymerase III subunit epsilon [EC: 2.7.7.7] [KO: K02342] [EC: 2.7.7.7] | | DNA polymerase III subunit chi; K02339 DNA polymerase III subunit chi [EC: 2.7.7.7] [KO: K02339] [EC: 2.7.7.7] | | priA; primosome assembly protein PriA [KO: K04066] [EC:3.6.4.-] |
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| Reference |
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| Authors |
Maloisel L, Fabre F, Gangloff S. |
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| Title |
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension. |
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| Journal |
Mol Cell Biol 28:1373-82 (2008) |
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| Reference |
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| Authors |
Haruta-Takahashi N, Iwasaki H. |
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| Title |
[Recombination mediators] Japanese |
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| Journal |
Seikagaku 79:449-53 (2007) |
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| Reference |
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| Authors |
Ouyang KJ, Woo LL, Ellis NA. |
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| Title |
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases. |
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| Journal |
Mech Ageing Dev 129:425-40 (2008) |
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| Reference |
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| Authors |
Kawabata M, Kawabata T, Nishibori M. |
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| Title |
Role of recA/RAD51 family proteins in mammals. |
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| Journal |
Acta Med Okayama 59:1-9 (2005) |
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| Reference |
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| Authors |
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A. |
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| Title |
Mitotic recombination in Saccharomyces cerevisiae. |
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| Journal |
Curr Genet 42:185-98 (2003) |
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| Reference |
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| Authors |
Heyer WD, Li X, Rolfsmeier M, Zhang XP. |
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| Title |
Rad54: the Swiss Army knife of homologous recombination? |
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| Journal |
Nucleic Acids Res 34:4115-25 (2006) |
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| Reference |
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| Authors |
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R. |
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| Title |
Recombination proteins and rescue of arrested replication forks. |
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| Journal |
DNA Repair (Amst) 6:967-80 (2007) |
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| Reference |
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| Authors |
Hanaoka F. |
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| Title |
[DNA Replication and Repair] (In Japanese) |
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| Journal |
Yodosha (2004) |
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| Reference |
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| Authors |
Ohashi E, Ohmori H. |
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| Title |
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese) |
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| Journal |
Cell Technology 19:1449-53 (2000) |
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| KO pathway |
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