KEGG   PATHWAY: rha03440Help
Entry
rha03440                    Pathway                                

Name
Homologous recombination - Rhodococcus jostii
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
rha03440  Homologous recombination
rha03440

Ortholog table
Module
rha_M00260  DNA polymerase III complex, bacteria [PATH:rha03440]
Other DBs
BSID: 37547
GO: 0000724
Organism
Rhodococcus jostii [GN:rha]
Gene
RHA1_ro01396  single-strand DNA binding protein [KO:K03111]
RHA1_ro03431  single-strand binding protein [KO:K03111]
RHA1_ro03669  recF; DNA replication and repair protein [KO:K03629]
RHA1_ro01225  probable DNA repair protein RecO [KO:K03584]
RHA1_ro04211  recombination protein [KO:K06187]
RHA1_ro06765  recA; recombinase A [KO:K03553]
RHA1_ro00990  polA; DNA-directed DNA polymerase I [KO:K02335] [EC:2.7.7.7]
RHA1_ro02325  probable DNA-directed DNA polymerase [KO:K02335] [EC:2.7.7.7]
RHA1_ro06893  ruvA; holliday junction DNA helicase [KO:K03550] [EC:3.6.4.12]
RHA1_ro06894  ruvB; holliday junction DNA helicase [KO:K03551] [EC:3.6.4.12]
RHA1_ro06892  ruvC; crossover junction endoribonuclease [KO:K01159] [EC:3.1.22.4]
RHA1_ro06516  recG; ATP-dependent DNA helicase [KO:K03655] [EC:3.6.4.12]
RHA1_ro01837  exodeoxyribonuclease V beta subunit [KO:K03582] [EC:3.1.11.5]
RHA1_ro01838  recC; exodeoxyribonuclease V gamma subunit [KO:K03583] [EC:3.1.11.5]
RHA1_ro01836  probable exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
RHA1_ro01069  dnaE1; DNA-directed DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
RHA1_ro03667  dnaN; DNA-directed DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
RHA1_ro04199  DNA polymerase III subunit [KO:K02343] [EC:2.7.7.7]
RHA1_ro01286  possible DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
RHA1_ro04354  probable DNA-directed DNA polymerase III delta prime subunit [KO:K02341] [EC:2.7.7.7]
RHA1_ro01126  DNA-directed DNA polymerase [KO:K02342] [EC:2.7.7.7]
RHA1_ro10065  possible exonuclease [KO:K02342] [EC:2.7.7.7]
RHA1_ro05104  DNA polymerase [KO:K02342] [EC:2.7.7.7]
RHA1_ro01831  probable DNA polymerase III [KO:K02342] [EC:2.7.7.7]
RHA1_ro07159  probable primosomal protein N [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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