KEGG   PATHWAY: rle03440Help
Entry
rle03440                    Pathway                                

Name
Homologous recombination - Rhizobium leguminosarum bv. viciae 3841
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
rle03440  Homologous recombination
rle03440

Ortholog table
Module
rle_M00260  DNA polymerase III complex, bacteria [PATH:rle03440]
Other DBs
BSID: 39688
GO: 0000724
Organism
Rhizobium leguminosarum bv. viciae 3841 [GN:rle]
Gene
RL2099  recJ; putative single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
RL2399  ssb; putative single-strand binding protein (ssb) [KO:K03111]
RL0148  recF; putative DNA replication and repair protein [KO:K03629]
RL1515  recO; putative DNA repair protein (recombination protein O) [KO:K03584]
RL0131A  recR; putative recombination protein [KO:K06187]
RL2637  recA; putative recombinase [KO:K03553]
RL0160  polA; putative DNA polymerase I [KO:K02335] [EC:2.7.7.7]
RL3989  ruvA; putative Holliday junction DNA helicase [KO:K03550] [EC:3.6.4.12]
RL3990  ruvB; putative Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
RL3986  ruvC; putative crossover Holliday junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
RL2384  recG; putative ATP-dependent DNA helicase [KO:K03655] [EC:3.6.4.12]
RL4697  dnaE1; putative DNA polymerase I alpha subunit [KO:K02337] [EC:2.7.7.7]
RL1723  dnaE3; putative DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
RL0334  dnaN; putative DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
RL0134  dnaX; putative DNA polymerase III [KO:K02343] [EC:2.7.7.7]
RL4734  conserved hypothetical protein [KO:K02340] [EC:2.7.7.7]
RL2475  holB; putative DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
RL3291  putative DNA polymerase/exonuclease [KO:K02342] [EC:2.7.7.7]
RL0005  putative DNA polymerase subunit [KO:K02342] [EC:2.7.7.7]
pRL110533  putative exonuclease/polymerase [KO:K02342] [EC:2.7.7.7]
RL1572  putative DNA polymerase III subunit [KO:K02339] [EC:2.7.7.7]
RL4412  priA; putative primosomal protein N' (replication factor y) [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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