KEGG   PATHWAY: rme00280
Entry
rme00280                    Pathway                                
Name
Valine, leucine and isoleucine degradation - Cupriavidus metallidurans
Class
Metabolism; Amino acid metabolism
Pathway map
rme00280  Valine, leucine and isoleucine degradation
rme00280

Module
rme_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:rme00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Cupriavidus metallidurans [GN:rme]
Gene
Rmet_0493  ilvE; branched-chain amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]
Rmet_4134  pdhA; putative oxidoreductase (puryvate dehydrogenase E1 component, alpha subunit) [KO:K00166] [EC:1.2.4.4]
Rmet_4133  pdhB; putative oxidoreductase (puryvate dehydrogenase E1 component, beta subunit) [KO:K00167] [EC:1.2.4.4]
Rmet_4132  putative di-hydro-lipoamide acetyltransferase (E2 component of pyruvate dehydrogenase complex) [KO:K09699] [EC:2.3.1.168]
Rmet_2048  odhL; dihydrolipoamide dehydrogenase (E3 component) [KO:K00382] [EC:1.8.1.4]
Rmet_1199  lpdA; Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Rmet_4888  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Rmet_4216  lpdA2; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Rmet_2398  putative pyridine nucleotide-disulfide oxidoreductase, class I [KO:K00382] [EC:1.8.1.4]
Rmet_0108  acyl-CoA dehydrogenase, short-chain specific [KO:K00248] [EC:1.3.8.1]
Rmet_5357  putative Acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
Rmet_5358  putative Acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
Rmet_0845  Acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
Rmet_0968  Acyl-CoA dehydrogenase (ACAD) [KO:K00249] [EC:1.3.8.7]
Rmet_4458  acdA; acyl-CoA dehydrogenase-like protein [KO:K00249] [EC:1.3.8.7]
Rmet_3412  Acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
Rmet_4410  Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central region [KO:K00249] [EC:1.3.8.7]
Rmet_4575  acyl-CoA dehydrogenase-like protein [KO:K00249] [EC:1.3.8.7]
Rmet_4574  acyl-CoA dehydrogenase protein [KO:K00249] [EC:1.3.8.7]
Rmet_4613  acyl-CoA dehydrogenase-like protein [KO:K00249] [EC:1.3.8.7]
Rmet_3899  acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
Rmet_2199  acyl-CoA dehydrogenase-like protein [KO:K00249] [EC:1.3.8.7]
Rmet_1814  acyl-CoA dehydrogenase, short-chain specific [KO:K00249] [EC:1.3.8.7]
Rmet_5837  acyl-CoA dehydrogenase-like protein [KO:K00249] [EC:1.3.8.7]
Rmet_5143  putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
Rmet_2530  ivd; isovaleryl-CoA dehydrogenase (IVDHase) [KO:K00249] [EC:1.3.8.7]
Rmet_2531  ivd1; isovaleryl-CoA dehydrogenase (IVDHase) [KO:K00249] [EC:1.3.8.7]
Rmet_4075  acyl-CoA dehydrogenase-like protein [KO:K00249] [EC:1.3.8.7]
Rmet_5507  Long-chain-acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
Rmet_0103  ivd1; isovaleryl-CoA dehydrogenase [KO:K00253] [EC:1.3.8.4]
Rmet_3162  paaF; enoyl-CoA hydratase-isomerase [KO:K01692] [EC:4.2.1.17]
Rmet_5511  3-hydroxybutyryl-CoA epimerase (3-hydroxyacyl-CoA dehydrogenase, NAD-binding) [KO:K01782] [EC:1.1.1.35 4.2.1.17 5.1.2.3]
Rmet_0387  fadA; acetyl-CoA C-acyltransferase [KO:K00632] [EC:2.3.1.16]
Rmet_4459  NADP oxidoreductase, coenzyme F420-dependent:6-phosphogluconate dehydrogenase, NAD-binding [KO:K00020] [EC:1.1.1.31]
Rmet_4431  6-phosphogluconate dehydrogenase, NAD-binding [KO:K00020] [EC:1.1.1.31]
Rmet_0206  mmsA; Methylmalonate-semialdehyde dehydrogenase [KO:K00140] [EC:1.2.1.18 1.2.1.27]
Rmet_0677  puuC; gamma-Glu-gamma-aminobutyraldehyde dehydrogenase, NAD(P)H-dependent [KO:K00128] [EC:1.2.1.3]
Rmet_1898  aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
Rmet_5017  betB; NAD+-dependent betaine aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
Rmet_4856  puuC; aldehyde dehydrogenase (acceptor) [KO:K00128] [EC:1.2.1.3]
Rmet_1577  betB; Betaine-aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
Rmet_2794  matB; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [KO:K18661] [EC:6.2.1.76 6.2.1.-]
Rmet_0205  aptA; Beta-alanine-pyruvate aminotransferase [KO:K00822] [EC:2.6.1.18]
Rmet_0608  accC; acetyl-CoA carboxylase, biotin carboxylase subunit [KO:K01968] [EC:6.4.1.4]
Rmet_0609  accB; Acetyl/propionyl-CoA carboxylase,carboxyltransferase subunit [KO:K01969] [EC:6.4.1.4]
Rmet_0113  Enoyl-CoA hydratase/carnithine racemase [KO:K13766] [EC:4.2.1.18]
Rmet_2124  hydroxymethylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
Rmet_0607  hydroxymethylglutaryl-coenzyme a lyase active site; protein [KO:K01640] [EC:4.1.3.4]
Rmet_1153  atoD; acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit [KO:K01028] [EC:2.8.3.5]
Rmet_1154  atoA; acetyl-CoA:acetoacetyl-CoA transferase, beta subunit [KO:K01029] [EC:2.8.3.5]
Rmet_2699  acsA; Acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
Rmet_0106  atoB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Rmet_1357  phaA; Acetyl-CoA acetyltransferase (Acetoacetyl-CoA thiolase) [KO:K00626] [EC:2.3.1.9]
Rmet_1362  bktB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Rmet_5156  paaE; beta-ketoadipyl CoA thiolase [KO:K00626] [EC:2.3.1.9]
Rmet_1853  atoB; acetyl-CoA acetyltransferase / thiolase [KO:K00626] [EC:2.3.1.9]
Rmet_3805  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Rmet_4413  acetyl-CoA acetyltransferase (thiolase) [KO:K00626] [EC:2.3.1.9]
Rmet_5432  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Rmet_5499  Acetyl-CoA acetyltransferase (Thiolase) [KO:K00626] [EC:2.3.1.9]
Rmet_5510  beta-ketoadipyl CoA thiolase [KO:K00626] [EC:2.3.1.9]
Rmet_5540  putative Acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
rme00020  Citrate cycle (TCA cycle)
rme00240  Pyrimidine metabolism
rme00290  Valine, leucine and isoleucine biosynthesis
rme00640  Propanoate metabolism
rme00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (62)   
   KEGG GENES (62)   
All databases (63)   

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