KEGG   PATHWAY: rmr00790Help
Entry
rmr00790                    Pathway                                
Name
Folate biosynthesis - Rhodothermus marinus DSM 4252
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
Folate biosynthesis
rmr00790

All organismsOrtholog table
Module
Tetrahydrofolate biosynthesis, GTP => THF [PATH:rmr00790]
Other DBs
BSID: 
GO: 
Organism
Rhodothermus marinus DSM 4252 [GN:rmr]
Gene
GTP cyclohydrolase I; K01495 GTP cyclohydrolase I [EC:3.5.4.16] [KO:K01495] [EC:3.5.4.16]
alkaline phosphatase; K01077 alkaline phosphatase [EC:3.1.3.1] [KO:K01077] [EC:3.1.3.1]
phosphodiesterase/alkaline phosphatase D; K01113 alkaline phosphatase D [EC:3.1.3.1] [KO:K01113] [EC:3.1.3.1]
dihydroneopterin aldolase; K01633 dihydroneopterin aldolase [EC:4.1.2.25] [KO:K01633] [EC:4.1.2.25]
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; K00950 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] [KO:K00950] [EC:2.7.6.3]
dihydropteroate synthase; K00796 dihydropteroate synthase [EC:2.5.1.15] [KO:K00796] [EC:2.5.1.15]
Dihydrofolate reductase; K00287 dihydrofolate reductase [EC:1.5.1.3] [KO:K00287] [EC:1.5.1.3]
bifunctional folylpolyglutamate synthase/dihydrofolate synthase; K11754 dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] [KO:K11754] [EC:6.3.2.17 6.3.2.12]
hypothetical protein; K01737 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50] [KO:K01737] [EC:4.1.2.50 4.2.3.12]
hypothetical protein; K01737 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50] [KO:K01737] [EC:4.1.2.50 4.2.3.12]
exsB protein; K06920 7-cyano-7-deazaguanine synthase [EC:6.3.4.20] [KO:K06920] [EC:6.3.4.20]
molybdenum cofactor biosynthesis protein A; K03639 molybdenum cofactor biosynthesis protein [KO:K03639]
molybdenum cofactor biosynthesis protein C; K03637 molybdenum cofactor biosynthesis protein C [KO:K03637]
molybdopterin biosynthesis protein MoaE; K03635 molybdopterin synthase catalytic subunit [EC:2.-.-.-] [KO:K03635] [EC:2.-.-.-]
sulfur transfer protein ThiS; K03636 molybdopterin synthase sulfur carrier subunit [KO:K03636]
para-aminobenzoate synthase subunit I; K03342 para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38] [KO:K03342] [EC:4.1.3.38 2.6.1.85]
Compound
C00044  
GTP
C00101  
Tetrahydrofolate
C00251  
Chorismate
C00266  
Glycolaldehyde
C00268  
Dihydrobiopterin
C00272  
Tetrahydrobiopterin
C00415  
Dihydrofolate
C00504  
Folate
C00568  
4-Aminobenzoate
C00921  
Dihydropteroate
C01217  
5,6,7,8-Tetrahydromethanopterin
C01300  
2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
C03541  
Tetrahydrofolyl-[Glu](n)
C03684  
6-Pyruvoyltetrahydropterin
C04244  
6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  
2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine
C04874  
2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
C04895  
7,8-Dihydroneopterin 3'-triphosphate
C05922  
Formamidopyrimidine nucleoside triphosphate
C05923  
2,5-Diaminopyrimidine nucleoside triphosphate
C05924  
Molybdopterin
C05925  
Dihydroneopterin phosphate
C05926  
Neopterin
C05927  
7,8-Dihydromethanopterin
C06148  
2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06149  
6-(3'-Triphosphoryl-1'-methylglyceryl)-7-methyl-7,8-dihydrobiopterin
C09332  
Tetrahydrofolyl-[Glu](2)
C11355  
4-Amino-4-deoxychorismate
C15996  
7-Cyano-7-carbaguanine
C16675  
7-Aminomethyl-7-carbaguanine
C18239  
Precursor Z
C20239  
6-Carboxy-5,6,7,8-tetrahydropterin
C20248  
7-Carboxy-7-carbaguanine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
Reference
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
Reference
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
Reference
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
KO pathway
 
DBGET integrated database retrieval system