KEGG PATHWAY: rn00300

PATHWAY: rn00300

Entry

rn00300 Pathway

Name

Lysine biosynthesis

Class

Metabolism; Amino acid metabolism

Pathway map

rn00300

Lysine biosynthesis

Module

M00016	Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:rn00300]
M00030	Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine [PATH:rn00300]
M00031	Lysine biosynthesis, 2-aminoadipate => lysine [PATH:rn00300]
M00433	Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate [PATH:rn00300]
M00525	Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine [PATH:rn00300]
M00526	Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine [PATH:rn00300]
M00527	Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine [PATH:rn00300]

Other DBs

GO:

0009085

Reaction

R00271	acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
R00451	meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)
R00480	ATP:L-aspartate 4-phosphotransferase
R00715	N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
R01773	L-Homoserine:NAD+ oxidoreductase
R01775	L-homoserine:NADP+ oxidoreductase
R01934	(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
R01939	L-2-aminoadipate:2-oxoglutarate aminotransferase
R02291	L-Aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
R02315	N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase
R02733	N6-Acetyl-LL-2,6-diaminoheptanedioate amidohydrolase
R02734	N-Succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
R02735	LL-2,6-Diaminoheptanedioate 2-epimerase
R02755	meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)
R02788	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)
R03098	L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
R03444	(R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase
R04198	2,3,4,5-tetrahydrodipicolinate:NAD+ 4-oxidoreductase
R04199	2,3,4,5-tetrahydrodipicolinate:NADP+ 4-oxidoreductase
R04336
R04364	Acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase
R04365	Succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
R04371	Homoisocitrate hydro-lyase
R04390	L-2-Aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
R04467
R04475	N-Succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate amino-transferase
R04617	UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate:D-alanyl-D-alanine ligase(ADP-forming)
R04863	L-2-Aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
R07613	LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase
R09775	LysW:L-2-aminoadipate ligase (ADP-forming)
R09776	ATP:LysW-gamma-L-alpha-aminoadipate 6-phosphotransferase
R09777	LysW-gamma-L-alpha-aminoadipate 6-semialdehyde:NADP+ 6-oxidoreductase (phosphorylating)
R09778	LysW-gamma-L-lysine:2-oxoglutarate 6-aminotransferase
R09779	LysW-gamma-L-lysine carboxypeptidase
R10010	L-lysine carboxy-aminomethylmutase
R10011
R10012
R10013
R10147	L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate-forming]

Compound

C00024	Acetyl-CoA
C00026	2-Oxoglutarate
C00047	L-Lysine
C00049	L-Aspartate
C00263	L-Homoserine
C00322	2-Oxoadipate
C00441	L-Aspartate 4-semialdehyde
C00449	N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00666	LL-2,6-Diaminoheptanedioate
C00680	meso-2,6-Diaminoheptanedioate
C00956	L-2-Aminoadipate
C01251	(R)-2-Hydroxybutane-1,2,4-tricarboxylate
C03082	4-Phospho-L-aspartate
C03871	L-2-Amino-6-oxoheptanedioate
C03972	2,3,4,5-Tetrahydrodipicolinate
C04002	(Z)-But-1-ene-1,2,4-tricarboxylate
C04076	L-2-Aminoadipate 6-semialdehyde
C04390	N6-Acetyl-LL-2,6-diaminoheptanedioate
C04421	N-Succinyl-LL-2,6-diaminoheptanedioate
C04462	N-Succinyl-2-L-amino-6-oxoheptanedioate
C04877	UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate
C04882	UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05535	alpha-Aminoadipoyl-S-acyl enzyme
C05539	N-Acetyl-L-2-amino-6-oxopimelate
C05560	L-2-Aminoadipate adenylate
C05662	Homoisocitrate
C16138	L-Pyrrolysine
C19886	LysW-gamma-L-alpha-aminoadipate
C19887	LysW-gamma-L-alpha-aminoadipyl-6-phosphate
C19888	LysW-gamma-L-alpha-aminoadipate 6-semialdehyde
C19889	LysW-gamma-L-lysine
C20258	(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate
C20277	(2R,3R)-3-Methylornithine
C20278	(2R,3R)-3-Methylornithinyl-N6-lysine
C20279	(2R,3R)-3-Methylglutamyl-5-semialdehyde-N6-lysine

Reference

PMID:10074354

Authors

Ledwidge R, Blanchard JS.

Title

The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis.

Journal

Biochemistry 38:3019-3024 (1999)

Reference

PMID:10850974

Authors

Fuchs TM, Schneider B, Krumbach K, Eggeling L, Gross R.

Title

Characterization of a bordetella pertussis diaminopimelate (DAP) biosynthesis locus identifies dapC, a novel gene coding for an N-succinyl-L,L-DAP aminotransferase.

Journal

J Bacteriol 182:3626-3631 (2000)

Reference

PMID:10714900

Authors

Zabriskie TM, Jackson MD.

Title

Lysine biosynthesis and metabolism in fungi.

Journal

Nat Prod Rep 17:85-97 (2000)

Reference

PMID:14627808

Authors

Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS.

Title

Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?

Journal

Nucleic Acids Res 31:6748-57 (2003)

Reference

PMID:12355264

Authors

Velasco AM, Leguina JI, Lazcano A.

Title

Molecular evolution of the lysine biosynthetic pathways.

Journal

J Mol Evol 55:445-59 (2002)

Reference

PMID:15256574

Authors

Miyazaki T, Miyazaki J, Yamane H, Nishiyama M.

Title

alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus.

Journal

Microbiology 150:2327-34 (2004)

Reference

PMID:12126930

Authors

Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT.

Title

Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).

Journal

Mol Genet Metab 76:172-80 (2002)

Reference

PMID:15160885

Authors

Nishiyama M.

Title

[Novel lysine biosynthesis: a key to elucidate evolution of metabolic and biosynthetic pathways]

Journal

Tanpakushitsu Kakusan Koso 49:758-63 (2004)

Reference

PMID:10613839

Authors

Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H.

Title

A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis.

Journal

Genome Res 9:1175-83 (1999)

Reference

PMID:12963379

Authors

Sakai H, Vassylyeva MN, Matsuura T, Sekine S, Gotoh K, Nishiyama M, Terada T, Shirouzu M, Kuramitsu S, Vassylyev DG, Yokoyama S.

Title

Crystal structure of a lysine biosynthesis enzyme, LysX, from Thermus thermophilus HB8.

Journal

J Mol Biol 332:729-40 (2003)

Reference

PMID:16361515

Authors

Hudson AO, Singh BK, Leustek T, Gilvarg C.

Title

An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants.

Journal

Plant Physiol 140:292-301 (2006)

Reference

PMID:19620981

Authors

Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M

Title

Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.

Journal

Nat Chem Biol 5:673-9 (2009)

Reference

PMID:21547300

Authors

Dairi T, Kuzuyama T, Nishiyama M, Fujii I

Title

Convergent strategies in biosynthesis.

Journal

Nat Prod Rep 28:1054-86 (2011)

Reference

PMID:21550296

Authors

Gaston MA, Jiang R, Krzycki JA

Title

Functional context, biosynthesis, and genetic encoding of pyrrolysine.

Journal

Curr Opin Microbiol 14:342-9 (2011)

KO pathway

ko00300

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Pathway (9)   
   KEGG PATHWAY (2)   
   KEGG MODULE (7)   
Chemical substance (35)   
   KEGG COMPOUND (35)   
Chemical reaction (65)   
   KEGG REACTION (39)   
   KEGG RCLASS (26)   
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