KEGG PATHWAY: rn00520

PATHWAY: rn00520

Entry

rn00520 Pathway

Name

Amino sugar and nucleotide sugar metabolism

Class

Metabolism; Carbohydrate metabolism

Pathway map

rn00520

Amino sugar and nucleotide sugar metabolism

Module

M00267	PTS system, N-acetylglucosamine-specific II component [PATH:rn00520]
M00282	PTS system, D-glucosamine-specific II component [PATH:rn00520]
M00361	Nucleotide sugar biosynthesis, eukaryotes [PATH:rn00520]
M00362	Nucleotide sugar biosynthesis, prokaryotes [PATH:rn00520]
M00549	Nucleotide sugar biosynthesis, glucose => UDP-glucose [PATH:rn00520]
M00554	Nucleotide sugar biosynthesis, galactose => UDP-galactose [PATH:rn00520]

Reaction

R00022	chitobiose N-acetylglucosaminohydrolase
R00100	NADH:ferricytochrome-b5 oxidoreductase
R00286	UDP-glucose:NAD+ 6-oxidoreductase
R00289	UTP:alpha-D-glucose-1-phosphate uridylyltransferase
R00291	UDP-glucose 4-epimerase
R00293	UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)
R00414	UDP-N-acetyl-D-glucosamine 2-epimerase
R00416	UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase
R00418	UDP-N-acetyl-D-glucosamine 4-epimerase
R00420	UDP-N-acetyl-D-glucosamine 2-epimerase
R00421	UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase
R00501	UDP-alpha-D-galactose:NAD+ 6-oxidoreductase
R00502	UTP:alpha-D-galactose-1-phosphate uridylyltransferase
R00660	Phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyl-transferase
R00765	D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing)
R00768	L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
R00880	GDP-D-mannose:NAD+ 6-oxidoreductase
R00883	GDP:D-mannose-1-phosphate guanylyltransferase
R00885	GTP:alpha-D-mannose-1-phosphate guanylyltransferase
R00888	GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)
R00889	GDP-mannose 3,5-epimerase
R00948	ATP:alpha-D-glucose-1-phosphate adenylyltransferase
R00954	GTP:alpha-D-glucose-1-phosphate guanylyltransferase
R00955	UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase
R00956	CTP:alpha-D-glucose-1-phosphate cytidylyltransferase
R00959	alpha-D-Glucose 1-phosphate 1,6-phosphomutase
R01092	ATP:D-galactose 1-phosphotransferase
R01115	CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)
R01117	CTP:N-acetylneuraminate cytidylyltransferase
R01200	N-Acetyl-D-glucosamine amidohydrolase
R01201	ATP:N-acetyl-D-glucosamine 6-phosphotransferase
R01204	Acetyl-CoA:D-glucosamine N-acetyltransferase
R01206	[1,4-(N-Acetyl-beta-D-glucosaminyl)]n glycanohydrolase
R01207	N-acetyl-D-glucosamine 2-epimerase
R01326	ATP:D-mannose 6-phosphotransferase
R01381	UTP:1-phospho-alpha-D-glucuronate uridylyltransferase
R01384	UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)
R01385	UDP-glucuronate 4-epimerase
R01386	UDP-D-glucuronate carboxy-lyase (UDP-D-apiose-forming)
R01387	UDP-glucuronate 5'-epimerase
R01433	D-xylose xylohydrolase
R01471	UTP:alpha-D-xylose-1-phosphate uridylyltransferase
R01473	UDP-L-arabinose 4-epimerase
R01476	ATP:D-glucuronate 1-phosphotransferase
R01754	ATP:L-arabinose 1-phosphotransferase
R01762	alpha-L-arabinan arabinofuranohydrolase
R01786	ATP:alpha-D-glucose 6-phosphotransferase
R01803	N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)
R01804	phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
R01805	N-Acetylneuraminate 9-phosphate phosphohydrolase
R01811	N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
R01818	D-mannose 6-phosphate 1,6-phosphomutase
R01819	D-mannose-6-phosphate aldose-ketose-isomerase
R01951	GTP:beta-L-fucose-1-phosphate guanylyltransferase
R01961	ATP:D-glucosamine 6-phosphotransferase
R01966	beta-D-glucosaminide glucosaminohydrolase
R01980	ATP:D-galacturonate 1-phosphotransferase
R02058	acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
R02059	N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
R02060	D-Glucosamine 1-phosphate 1,6-phosphomutase
R02087	N-Acetyl-D-glucosamine 6-phosphate 2-epimerase
R02189	Polyphosphate:D-glucose 6-phosphotransferase
R02333	Chitin amidohydrolase
R02334	[1,4-(N-Acetyl-beta-D-glucosaminyl)]n glycanohydrolase
R02335	UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase
R02426	CDPglucose 4,6-hydro-lyase
R02630	Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase
R02631	Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase
R02634	UTP:1-Phospho-alpha-D-galacturonate uridylyltransferase
R02636	UDP-D-galacturonate carboxy-lyase
R02705	ATP:N-acyl-D-mannosamine 6-phosphotransferase
R02707	N-acetyl-D-mannosamine N-acetylmannosaminohydrolase
R02738	Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase
R02740	alpha-D-Glucose 6-phosphate ketol-isomerase
R02833	Chitosan N-acetylglucosaminohydrolase
R03077	UTP:beta-L-arabinose-1-phosphate uridylyltransferase
R03078
R03161	ATP:6-deoxy-L-galactose 1-phosphotransferase
R03191	UDP-N-acetylmuramate:NADP+ oxidoreductase
R03192	UDP-N-acetylmuramate:NADP+ oxidoreductase
R03317	UDP-N-acetyl-alpha-D-mannosamine:NAD+ 6-oxidoreductase
R03391	CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD+ 3-oxydoreductase
R03392	CDP-4-dehydro-3,6-dideoxy-D-glucose:NADP+ 3-oxydoreductase
R03396	GDP-6-deoxy-D-talose:NAD+ 4-oxidoreductase
R03397	GDP-6-deoxy-D-mannose:NAD+ 4-oxidoreductase
R03398	GDP-6-deoxy-D-talose:NADP+ 4-oxidoreductase
R03399	GDP-6-deoxy-D-mannose:NADP+ 4-oxidoreductase
R03920	ATP:D-fructose 6-phosphotransferase
R03928	UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase
R04215	CTP:N-glycoloylneuraminate cytidylyltransferase
R04265	CDP-alpha-D-paratose:NADP+ 4-oxidoreductase
R04266	CDP-3,6-dideoxy-D-glucose 2-epimerase
R04435	phosphoenolpyruvate:N-acetyl-D-mannosamine-6-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
R05191	UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase
R05199	Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase
R05332	Acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase
R05692	GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)
R05775	UDP-6-sulfo-6-deoxyglucose sulfohydrolase
R06894
R07658
R07659
R07660
R07661	UDP-4-deoxy-4-formamido-L-arabinose:undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinosyltransferase
R07672
R08193	N-Acetyl-D-glucosamine 1-phosphate 1,6-phosphomutase
R08555	(R)-lactate hydro-lyase (adding N-acetyl-D-glucosamine 6-phosphate; N-acetylmuramate 6-phosphate-forming)
R08559	Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase
R08704	UDP-4-dehydro-6-deoxy-glucose 3,5-epimerase
R08705	UDP-L-rhamnose:NADP+ 4-oxidoreductase
R08706	UDP-N-acetyl-D-glucosaminuronate 4-epimerase
R08708	CDP-4-dehydro-3,6-dideoxy-D-glucose 5-epimerase
R08709	CDP-ascarylose:NAD+ 4-oxidoreductase
R08710	CDP-ascarylose:NADP+ 4-oxidoreductase
R08711	CDP-abequose:NADP+ 4-oxidoreductase
R08860
R09600	2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate 2-epimerase
R09697	UDP-N-acetylglucosamine hydro-lyase (inverting; UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose-forming)
R09825	UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine:2-oxoglutarate aminotransferase
R09834	UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose hydrolase
R09841	phosphoenolpyruvate:2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose transferase (phosphate-hydrolysing, 2,7-acetylamino-transfering, 2-carboxy-2-oxoethyl-forming)
R09842	acetyl-CoA:UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine 4-N-acetyltransferase
R09843	CTP:pseudaminate cytidylyltransferase
R10100	acetyl-CoA:UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate 3-N-acetyltransferase
R10140	UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate:NAD+ 3-oxidoreductase
R10141	UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate:2-oxoglutarate aminotransferase

Compound

C00029	UDP-glucose
C00031	D-Glucose
C00043	UDP-N-acetyl-alpha-D-glucosamine
C00052	UDP-alpha-D-galactose
C00096	GDP-mannose
C00103	D-Glucose 1-phosphate
C00124	D-Galactose
C00128	CMP-N-acetylneuraminate
C00140	N-Acetyl-D-glucosamine
C00159	D-Mannose
C00167	UDP-glucuronate
C00181	D-Xylose
C00190	UDP-D-xylose
C00191	D-Glucuronate
C00203	UDP-N-acetyl-D-galactosamine
C00259	L-Arabinose
C00267	alpha-D-Glucose
C00270	N-Acetylneuraminate
C00275	D-Mannose 6-phosphate
C00325	GDP-L-fucose
C00329	D-Glucosamine
C00333	D-Galacturonate
C00352	D-Glucosamine 6-phosphate
C00357	N-Acetyl-D-glucosamine 6-phosphate
C00394	GDP-glucose
C00446	alpha-D-Galactose 1-phosphate
C00461	Chitin
C00498	ADP-glucose
C00501	CDP-glucose
C00617	UDP-D-galacturonate
C00636	D-Mannose 1-phosphate
C00645	N-Acetyl-D-mannosamine
C00668	alpha-D-Glucose 6-phosphate
C00714	Pectin
C00734	Chitosan
C00935	UDP-L-arabinose
C00976	GDP-D-mannuronate
C00996	Ferricytochrome b5
C00999	Ferrocytochrome b5
C01019	6-Deoxy-L-galactose
C01050	UDP-N-acetylmuramate
C01170	UDP-N-acetyl-D-mannosamine
C01219	CDP-4-dehydro-6-deoxy-D-glucose
C01222	GDP-4-dehydro-6-deoxy-D-mannose
C01623	UDP-apiose
C01674	Chitobiose
C01788	CDP-abequose
C02199	UDP-L-rhamnose
C02280	GDP-L-galactose
C02330	UDP-L-iduronate
C02336	beta-D-Fructose
C02352	1,4-beta-D-Xylan
C02474	Arabinan
C02713	N-Acetylmuramate
C02977	GDP-6-deoxy-D-talose
C02985	L-Fucose 1-phosphate
C03117	GDP-6-deoxy-D-mannose
C03410	N-Glycoloyl-neuraminate
C03598	CDP-3,6-dideoxy-D-glucose
C03599	CDP-3,6-dideoxy-D-mannose
C03691	CMP-N-glycoloylneuraminate
C03737	alpha-D-Xylose 1-phosphate
C03906	beta-L-Arabinose 1-phosphate
C04037	1-Phospho-alpha-D-galacturonate
C04089	UDP-4-dehydro-6-deoxy-D-glucose
C04257	N-Acetyl-D-mannosamine 6-phosphate
C04297	CDP-4-dehydro-3,6-dideoxy-D-glucose
C04501	N-Acetyl-alpha-D-glucosamine 1-phosphate
C04573	UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate
C04631	UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C05345	beta-D-Fructose 6-phosphate
C05385	D-Glucuronate 1-phosphate
C06023	D-Glucosaminide
C06156	alpha-D-Glucosamine 1-phosphate
C06240	UDP-N-acetyl-D-mannosaminouronate
C06241	N-Acetylneuraminate 9-phosphate
C11521	UDP-6-sulfoquinovose
C13952	UDP-N-acetyl-D-galactosaminuronic acid
C15925	GDP-L-gulose
C16153	UDP-L-Ara4N
C16154	UDP-L-Ara4FN
C16155	UDP-L-Ara4O
C16156	Undecaprenyl phosphate alpha-L-Ara4FN
C16698	N-Acetylmuramic acid 6-phosphate
C17326	CDP-4-dehydro-3,6-dideoxy-D-glucose epimer
C17327	CDP-ascarylose
C17328	UDP-4-keto-rhamnose
C19725	UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
C19745	UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
C19823	UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose
C19961	UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine
C19971	UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C19972	2,4-Bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C20082	Pseudaminic acid
C20083	CMP-pseudaminic acid
C20359	UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate
C20395	UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate

Reference

PMID:2793832

Authors

Wyk P, Reeves P

Title

Identification and sequence of the gene for abequose synthase, which confers antigenic specificity on group B salmonellae: homology with galactose epimerase.

Journal

J Bacteriol 171:5687-93 (1989)

Reference

PMID:8071227

Authors

Thorson JS, Lo SF, Ploux O, He X, Liu HW

Title

Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA.

Journal

J Bacteriol 176:5483-93 (1994)

Reference

PMID:8444803

Authors

Kessler AC, Haase A, Reeves PR

Title

Molecular analysis of the 3,6-dideoxyhexose pathway genes of Yersinia pseudotuberculosis serogroup IIA.

Journal

J Bacteriol 175:1412-22 (1993)

Reference

PMID:9811644

Authors

Danese PN, Oliver GR, Barr K, Bowman GD, Rick PD, Silhavy TJ

Title

Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.

Journal

J Bacteriol 180:5875-84 (1998)

Reference

PMID:10931327

Authors

Skurnik M, Peippo A, Ervela E

Title

Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b.

Journal

Mol Microbiol 37:316-30 (2000)

Reference

PMID:10984043

Authors

Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV

Title

Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.

Journal

Nature 406:959-64 (2000)

Reference

PMID:11447132

Authors

Ringenberg M, Lichtensteiger C, Vimr E

Title

Redirection of sialic acid metabolism in genetically engineered Escherichia coli.

Journal

Glycobiology 11:533-9 (2001)

Reference

PMID:12562791

Authors

McCoy AJ, Sandlin RC, Maurelli AT

Title

In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance.

Journal

J Bacteriol 185:1218-28 (2003)

Reference

PMID:14450717

Authors

JACOBSON B, DAVIDSON EA

Title

Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase.

Journal

J Biol Chem 237:638-42 (1962)

Reference

PMID:15134748

Authors

Seifert GJ

Title

Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside.

Journal

Curr Opin Plant Biol 7:277-84 (2004)

Reference

PMID:15489439

Authors

Uehara T, Park JT

Title

The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling.

Journal

J Bacteriol 186:7273-9 (2004)

Reference

PMID:15695810

Authors

Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR.

Title

A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.

Journal

J Biol Chem 280:14154-67 (2005)

Reference

PMID:15809294

Authors

Williams GJ, Breazeale SD, Raetz CR, Naismith JH.

Title

Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.

Journal

J Biol Chem 280:23000-8 (2005)

Reference

PMID:16237198

Authors

Maliekal P, Vertommen D, Delpierre G, Van Schaftingen E

Title

Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase.

Journal

Glycobiology 16:165-72 (2006)

Reference

PMID:16277754

Authors

Campbell CT, Yarema KJ

Title

Large-scale approaches for glycobiology.

Journal

Genome Biol 6:236 (2005)

Reference

PMID:16452451

Authors

Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT

Title

MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.

Journal

J Bacteriol 188:1660-2 (2006)

Reference

PMID:16995900

Authors

Lanot A, Hodge D, Jackson RG, George GL, Elias L, Lim EK, Vaistij FE, Bowles DJ

Title

The glucosyltransferase UGT72E2 is responsible for monolignol 4-O-glucoside production in Arabidopsis thaliana.

Journal

Plant J 48:286-95 (2006)

Reference

PMID:17085508

Authors

Muller R, Morant M, Jarmer H, Nilsson L, Nielsen TH

Title

Genome-wide analysis of the Arabidopsis leaf transcriptome reveals interaction of phosphate and sugar metabolism.

Journal

Plant Physiol 143:156-71 (2007)

Reference

PMID:17190829

Authors

Oka T, Nemoto T, Jigami Y

Title

Functional analysis of Arabidopsis thaliana RHM2/MUM4, a multidomain protein involved in UDP-D-glucose to UDP-L-rhamnose conversion.

Journal

J Biol Chem 282:5389-403 (2007)

Reference

PMID:17827295

Authors

Greenberg DE, Porcella SF, Zelazny AM, Virtaneva K, Sturdevant DE, Kupko JJ 3rd, Barbian KD, Babar A, Dorward DW, Holland SM.

Title

Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.

Journal

J Bacteriol 189:8727-36 (2007)

Reference

PMID:18199744

Authors

Kotake T, Hojo S, Tajima N, Matsuoka K, Koyama T, Tsumuraya Y

Title

A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.

Journal

J Biol Chem 283:8125-35 (2008)

Reference

PMID:18304669

Authors

Vorholter FJ, Schneiker S, Goesmann A, Krause L, Bekel T, Kaiser O, Linke B, Patschkowski T, Ruckert C, Schmid J, Sidhu VK, Sieber V, Tauch A, Watt SA, Weisshaar B, Becker A, Niehaus K, Puhler A.

Title

The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis.

Journal

J Biotechnol 134:33-45 (2008)

KO pathway

ko00520

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Pathway (8)   
   KEGG PATHWAY (2)   
   KEGG MODULE (6)   
Chemical substance (97)   
   KEGG COMPOUND (97)   
Chemical reaction (164)   
   KEGG REACTION (125)   
   KEGG RCLASS (39)   
Literature (22)   
   PubMed (22)   
All databases (291)   

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