Valine, leucine and isoleucine degradation

Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:rno00280]

2-oxoisovalerate:ferredoxin oxidoreductase [PATH:rno00280]

Bcat1; branched chain amino acid transaminase 1, cytosolic [KO:K00826] [EC:2.6.1.42]

Bcat2; branched chain amino acid transaminase 2, mitochondrial [KO:K00826] [EC:2.6.1.42]

Lao1; L-amino acid oxidase 1 [KO:K03334] [EC:1.4.3.2]

rCG53598-like; K03334 L-amino-acid oxidase [EC:1.4.3.2] [KO:K03334] [EC:1.4.3.2]

RGD1308564; similar to L-amino acid oxidase 1 [KO:K03334] [EC:1.4.3.2]

Bckdha; branched chain ketoacid dehydrogenase E1, alpha polypeptide [KO:K00166] [EC:1.2.4.4]

Bckdhb; branched chain keto acid dehydrogenase E1, beta polypeptide [KO:K00167] [EC:1.2.4.4]

Dbt; dihydrolipoamide branched chain transacylase E2 [KO:K09699] [EC:2.3.1.168]

Dld; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

Acads; acyl-CoA dehydrogenase, C-2 to C-3 short chain [KO:K00248] [EC:1.3.8.1]

Acadm; acyl-CoA dehydrogenase, C-4 to C-12 straight chain [KO:K00249] [EC:1.3.8.7]

Ivd; isovaleryl-CoA dehydrogenase [KO:K00253] [EC:1.3.8.4]

Acadsb; acyl-CoA dehydrogenase, short/branched chain [KO:K09478] [EC:1.3.99.12]

Acad8; acyl-CoA dehydrogenase family, member 8 [KO:K11538] [EC:1.3.99.-]

Hadha; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [KO:K07515] [EC:1.1.1.211 4.2.1.17]

Ehhadh; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:5.3.3.8 1.1.1.35 4.2.1.17]

Echs1; enoyl CoA hydratase, short chain, 1, mitochondrial [KO:K07511] [EC:4.2.1.17]

enoyl-CoA hydratase; K07511 enoyl-CoA hydratase [EC:4.2.1.17] [KO:K07511] [EC:4.2.1.17]

Hadh; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]

Hsd17b10; hydroxysteroid (17-beta) dehydrogenase 10 [KO:K08683] [EC:1.1.1.178 1.1.1.35]

Acaa1a; acetyl-Coenzyme A acyltransferase 1A [KO:K07513] [EC:2.3.1.16]

Acaa1b; acetyl-Coenzyme A acyltransferase 1B [KO:K07513] [EC:2.3.1.16]

Acaa2; acetyl-CoA acyltransferase 2 [KO:K07508] [EC:2.3.1.16]

Hadhb; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [KO:K07509] [EC:2.3.1.16]

Pcca; propionyl-coenzyme A carboxylase, alpha polypeptide [KO:K01965] [EC:6.4.1.3]

Pccb; propionyl CoA carboxylase, beta polypeptide [KO:K01966] [EC:6.4.1.3]

Mcee; methylmalonyl CoA epimerase [KO:K05606] [EC:5.1.99.1]

Mut; methylmalonyl CoA mutase [KO:K01847] [EC:5.4.99.2]

Hibch; 3-hydroxyisobutyryl-CoA hydrolase [KO:K05605] [EC:3.1.2.4]

Hibadh; 3-hydroxyisobutyrate dehydrogenase [KO:K00020] [EC:1.1.1.31]

Aldh6a1; aldehyde dehydrogenase 6 family, member A1 [KO:K00140] [EC:1.2.1.27 1.2.1.18]

Aldh2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]

Aldh3a2; aldehyde dehydrogenase 3 family, member A2 [KO:K00128] [EC:1.2.1.3]

Aldh1b1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]

Aldh7a1; aldehyde dehydrogenase 7 family, member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]

Aldh9a1; aldehyde dehydrogenase 9 family, member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]

Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]

Aox3l1; aldehyde oxidase 3-like 1 [KO:K00157] [EC:1.2.3.1]

Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]

Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]

Abat; 4-aminobutyrate aminotransferase [KO:K13524] [EC:2.6.1.22 2.6.1.19]

Mccc1; methylcrotonoyl-CoA carboxylase 1 (alpha) [KO:K01968] [EC:6.4.1.4]

Mccc2; methylcrotonoyl-CoA carboxylase 2 (beta) [KO:K01969] [EC:6.4.1.4]

Auh; AU RNA binding protein/enoyl-CoA hydratase [KO:K05607] [EC:4.2.1.18]

Hmgcl; 3-hydroxymethyl-3-methylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]

Oxct1; 3-oxoacid CoA transferase 1 [KO:K01027] [EC:2.8.3.5]

Oxct2a; 3-oxoacid CoA transferase 2A [KO:K01027] [EC:2.8.3.5]

rCG31267-like; K01027 3-oxoacid CoA-transferase [EC:2.8.3.5] [KO:K01027] [EC:2.8.3.5]

Acat1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]

Acat2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]

Hmgcs1; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) [KO:K01641] [EC:2.3.3.10]

Hmgcs2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) [KO:K01641] [EC:2.3.3.10]

Acetyl-CoA

Thiamin diphosphate

Succinyl-CoA

Propanoyl-CoA

L-Leucine

3-Methyl-2-oxobutanoic acid

Acetoacetate

L-Valine

4-Methyl-2-oxopentanoate

Acetoacetyl-CoA

(S)-3-Hydroxy-3-methylglutaryl-CoA

L-Isoleucine

2-Methylpropanoyl-CoA

(S)-3-Methyl-2-oxopentanoic acid

(S)-Methylmalonyl-CoA

(R)-Methylmalonyl-CoA

Methylmalonate

(3R)-beta-Leucine

3-Methylbutanoyl-CoA

3-Methylcrotonyl-CoA

3-Methylglutaconyl-CoA

L-3-Amino-isobutanoate

2-Methylacetoacetyl-CoA

2-Methylbut-2-enoyl-CoA

2-Methylprop-2-enoyl-CoA

beta-Ketoisocaproate

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA

Branched chain fatty acid

3-Hydroxyisovaleryl-CoA

(S)-3-Hydroxyisobutyryl-CoA

(S)-3-Hydroxyisobutyrate

(S)-Methylmalonate semialdehyde

Enzyme N6-(lipoyl)lysine

Enzyme N6-(dihydrolipoyl)lysine

3-Methyl-1-hydroxybutyl-ThPP

[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine

2-Methyl-1-hydroxypropyl-ThPP

[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine

2-Methyl-1-hydroxybutyl-ThPP

[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine

(S)-2-Methylbutanoyl-CoA