KEGG   PATHWAY: rno00280Help
Entry
rno00280                    Pathway                                

Name
Valine, leucine and isoleucine degradation - Rattus norvegicus (rat)
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Valine, leucine and isoleucine degradation
rno00280

All organismsOrtholog table
Module
Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:rno00280]
Other DBs
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
29592  
Bcat1; branched chain amino acid transaminase 1, cytosolic [KO:K00826] [EC:2.6.1.42]
64203  
Bcat2; branched chain amino acid transaminase 2, mitochondrial [KO:K00826] [EC:2.6.1.42]
298483  
Lao1; L-amino acid oxidase 1 [KO:K03334] [EC:1.4.3.2]
rCG53598-like; K03334 L-amino-acid oxidase [EC:1.4.3.2] [KO:K03334] [EC:1.4.3.2]
287305  
RGD1308564; similar to L-amino acid oxidase 1 [KO:K03334] [EC:1.4.3.2]
25244  
Bckdha; branched chain ketoacid dehydrogenase E1, alpha polypeptide [KO:K00166] [EC:1.2.4.4]
29711  
Bckdhb; branched chain keto acid dehydrogenase E1, beta polypeptide [KO:K00167] [EC:1.2.4.4]
29611  
Dbt; dihydrolipoamide branched chain transacylase E2 [KO:K09699] [EC:2.3.1.168]
298942  
Dld; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
64304  
Acads; acyl-CoA dehydrogenase, C-2 to C-3 short chain [KO:K00248] [EC:1.3.8.1]
24158  
Acadm; acyl-CoA dehydrogenase, C-4 to C-12 straight chain [KO:K00249] [EC:1.3.8.7]
24513  
Ivd; isovaleryl-CoA dehydrogenase [KO:K00253] [EC:1.3.8.4]
25618  
Acadsb; acyl-CoA dehydrogenase, short/branched chain [KO:K09478] [EC:1.3.99.12]
367196  
Acad8; acyl-CoA dehydrogenase family, member 8 [KO:K11538] [EC:1.3.99.-]
170670  
Hadha; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [KO:K07515] [EC:1.1.1.211 4.2.1.17]
171142  
Ehhadh; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:5.3.3.8 1.1.1.35 4.2.1.17]
140547  
Echs1; enoyl CoA hydratase, short chain, 1, mitochondrial [KO:K07511] [EC:4.2.1.17]
enoyl-CoA hydratase; K07511 enoyl-CoA hydratase [EC:4.2.1.17] [KO:K07511] [EC:4.2.1.17]
113965  
Hadh; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]
63864  
Hsd17b10; hydroxysteroid (17-beta) dehydrogenase 10 [KO:K08683] [EC:1.1.1.178 1.1.1.35]
24157  
Acaa1a; acetyl-CoA acyltransferase 1 [KO:K07513] [EC:2.3.1.16]
501072  
Acaa1b; acetyl-Coenzyme A acyltransferase 1B [KO:K07513] [EC:2.3.1.16]
170465  
Acaa2; acetyl-CoA acyltransferase 2 [KO:K07508] [EC:2.3.1.16]
171155  
Hadhb; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [KO:K07509] [EC:2.3.1.16]
687008  
Pcca; propionyl CoA carboxylase, alpha polypeptide [KO:K01965] [EC:6.4.1.3]
24624  
Pccb; propionyl CoA carboxylase, beta polypeptide [KO:K01966] [EC:6.4.1.3]
293829  
Mcee; methylmalonyl CoA epimerase [KO:K05606] [EC:5.1.99.1]
688517  
Mut; methylmalonyl CoA mutase [KO:K01847] [EC:5.4.99.2]
301384  
Hibch; 3-hydroxyisobutyryl-CoA hydrolase [KO:K05605] [EC:3.1.2.4]
63938  
Hibadh; 3-hydroxyisobutyrate dehydrogenase [KO:K00020] [EC:1.1.1.31]
81708  
Aldh6a1; aldehyde dehydrogenase 6 family, member A1 [KO:K00140] [EC:1.2.1.27 1.2.1.18]
29539  
Aldh2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
65183  
Aldh3a2; aldehyde dehydrogenase 3 family, member A2 [KO:K00128] [EC:1.2.1.3]
298079  
Aldh1b1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
291450  
Aldh7a1; aldehyde dehydrogenase 7 family, member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
64040  
Aldh9a1; aldehyde dehydrogenase 9 family, member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
54349  
Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
316421  
Aox2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
493909  
Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
316424  
Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
81632  
Abat; 4-aminobutyrate aminotransferase [KO:K13524] [EC:2.6.1.22 2.6.1.19]
294972  
Mccc1; methylcrotonoyl-CoA carboxylase 1 (alpha) [KO:K01968] [EC:6.4.1.4]
361884  
Mccc2; methylcrotonoyl-CoA carboxylase 2 (beta) [KO:K01969] [EC:6.4.1.4]
361215  
Auh; AU RNA binding protein/enoyl-CoA hydratase [KO:K05607] [EC:4.2.1.18]
79238  
Hmgcl; 3-hydroxymethyl-3-methylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
690163  
Oxct1; 3-oxoacid CoA transferase 1 [KO:K01027] [EC:2.8.3.5]
366463  
Oxct2a; 3-oxoacid CoA transferase 2A [KO:K01027] [EC:2.8.3.5]
65984  
Aacs; acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
25014  
Acat1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
308100  
Acat2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
29637  
Hmgcs1; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) [KO:K01641] [EC:2.3.3.10]
24450  
Hmgcs2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) [KO:K01641] [EC:2.3.3.10]
498962  
Acsf3; acyl-CoA synthetase family member 3 [KO:K18660] [EC:6.2.1.-]
Compound
C00024  
Acetyl-CoA
C00068  
Thiamin diphosphate
C00091  
Succinyl-CoA
C00100  
Propanoyl-CoA
C00123  
L-Leucine
C00141  
3-Methyl-2-oxobutanoic acid
C00164  
Acetoacetate
C00183  
L-Valine
C00233  
4-Methyl-2-oxopentanoate
C00332  
Acetoacetyl-CoA
C00356  
(S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  
L-Isoleucine
C00630  
2-Methylpropanoyl-CoA
C00671  
(S)-3-Methyl-2-oxopentanoic acid
C00683  
(S)-Methylmalonyl-CoA
C01213  
(R)-Methylmalonyl-CoA
C02170  
Methylmalonate
C02939  
3-Methylbutanoyl-CoA
C03069  
3-Methylcrotonyl-CoA
C03231  
3-Methylglutaconyl-CoA
C03284  
L-3-Amino-isobutanoate
C03344  
2-Methylacetoacetyl-CoA
C03345  
2-Methylbut-2-enoyl-CoA
C03460  
2-Methylprop-2-enoyl-CoA
C04405  
(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  
Branched chain fatty acid
C05998  
3-Hydroxyisovaleryl-CoA
C06000  
(S)-3-Hydroxyisobutyryl-CoA
C06001  
(S)-3-Hydroxyisobutyrate
C06002  
(S)-Methylmalonate semialdehyde
C15972  
Enzyme N6-(lipoyl)lysine
C15973  
Enzyme N6-(dihydrolipoyl)lysine
C15974  
3-Methyl-1-hydroxybutyl-ThPP
C15975  
[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  
2-Methyl-1-hydroxypropyl-ThPP
C15977  
[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  
2-Methyl-1-hydroxybutyl-ThPP
C15979  
[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  
(S)-2-Methylbutanoyl-CoA
C20827  
3-Hydroxyisovalerate
KO pathway
 

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