KEGG   PATHWAY: rno00280Help
Entry
rno00280                    Pathway                                

Name
Valine, leucine and isoleucine degradation - Rattus norvegicus (rat)
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
rno00280  Valine, leucine and isoleucine degradation
rno00280

Ortholog table
Module
rno_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:rno00280]
rno_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:rno00280]
Other DBs
BSID: 83345
GO: 0006550 0006552 0006574
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
29592  Bcat1; branched chain amino acid transaminase 1 [KO:K00826] [EC:2.6.1.42]
64203  Bcat2; branched chain amino acid transaminase 2 [KO:K00826] [EC:2.6.1.42]
298483  Lao1; L-amino acid oxidase 1 [KO:K03334] [EC:1.4.3.2]
100360621  Il4i1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
287305  RGD1308564; similar to L-amino acid oxidase 1 [KO:K03334] [EC:1.4.3.2]
25244  Bckdha; branched chain ketoacid dehydrogenase E1, alpha polypeptide [KO:K00166] [EC:1.2.4.4]
29711  Bckdhb; branched chain keto acid dehydrogenase E1 subunit beta [KO:K00167] [EC:1.2.4.4]
29611  Dbt; dihydrolipoamide branched chain transacylase E2 [KO:K09699] [EC:2.3.1.168]
298942  Dld; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
64304  Acads; acyl-CoA dehydrogenase, C-2 to C-3 short chain [KO:K00248] [EC:1.3.8.1]
24158  Acadm; acyl-CoA dehydrogenase, C-4 to C-12 straight chain [KO:K00249] [EC:1.3.8.7]
24513  Ivd; isovaleryl-CoA dehydrogenase [KO:K00253] [EC:1.3.8.4]
25618  Acadsb; acyl-CoA dehydrogenase, short/branched chain [KO:K09478] [EC:1.3.99.12]
367196  Acad8; acyl-CoA dehydrogenase family, member 8 [KO:K11538] [EC:1.3.99.-]
170670  Hadha; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [KO:K07515] [EC:1.1.1.211 4.2.1.17]
171142  Ehhadh; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:5.3.3.8 1.1.1.35 4.2.1.17]
140547  Echs1; enoyl CoA hydratase, short chain, 1, mitochondrial [KO:K07511] [EC:4.2.1.17]
100911186  enoyl-CoA hydratase, mitochondrial-like [KO:K07511] [EC:4.2.1.17]
113965  Hadh; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]
63864  Hsd17b10; hydroxysteroid (17-beta) dehydrogenase 10 [KO:K08683] [EC:1.1.1.178 1.1.1.35]
24157  Acaa1a; acetyl-CoA acyltransferase 1 [KO:K07513] [EC:2.3.1.16]
501072  Acaa1b; acetyl-Coenzyme A acyltransferase 1B [KO:K07513] [EC:2.3.1.16]
170465  Acaa2; acetyl-CoA acyltransferase 2 [KO:K07508] [EC:2.3.1.16]
171155  Hadhb; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [KO:K07509] [EC:2.3.1.16]
687008  Pcca; propionyl-CoA carboxylase alpha subunit [KO:K01965] [EC:6.4.1.3]
24624  Pccb; propionyl-CoA carboxylase beta subunit [KO:K01966] [EC:2.1.3.15 6.4.1.3]
293829  Mcee; methylmalonyl CoA epimerase [KO:K05606] [EC:5.1.99.1]
688517  Mut; methylmalonyl CoA mutase [KO:K01847] [EC:5.4.99.2]
301384  Hibch; 3-hydroxyisobutyryl-CoA hydrolase [KO:K05605] [EC:3.1.2.4]
63938  Hibadh; 3-hydroxyisobutyrate dehydrogenase [KO:K00020] [EC:1.1.1.31]
81708  Aldh6a1; aldehyde dehydrogenase 6 family, member A1 [KO:K00140] [EC:1.2.1.27 1.2.1.18]
29539  Aldh2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
65183  Aldh3a2; aldehyde dehydrogenase 3 family, member A2 [KO:K00128] [EC:1.2.1.3]
298079  Aldh1b1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
291450  Aldh7a1; aldehyde dehydrogenase 7 family, member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
64040  Aldh9a1; aldehyde dehydrogenase 9 family, member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
54349  Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
316421  Aox2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
493909  Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
316424  Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
498962  Acsf3; acyl-CoA synthetase family member 3 [KO:K18660] [EC:6.2.1.-]
81632  Abat; 4-aminobutyrate aminotransferase [KO:K13524] [EC:2.6.1.22 2.6.1.19]
83784  Agxt2; alanine-glyoxylate aminotransferase 2 [KO:K00827] [EC:2.6.1.40 2.6.1.44]
294972  Mccc1; methylcrotonoyl-CoA carboxylase 1 [KO:K01968] [EC:6.4.1.4]
361884  Mccc2; methylcrotonoyl-CoA carboxylase 2 [KO:K01969] [EC:6.4.1.4]
361215  Auh; AU RNA binding methylglutaconyl-CoA hydratase [KO:K05607] [EC:4.2.1.18]
79238  Hmgcl; 3-hydroxymethyl-3-methylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
367112  Hmgcll1; 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 [KO:K01640] [EC:4.1.3.4]
690163  Oxct1; 3-oxoacid CoA transferase 1 [KO:K01027] [EC:2.8.3.5]
366463  Oxct2a; 3-oxoacid CoA transferase 2A [KO:K01027] [EC:2.8.3.5]
100361036  rCG31267-like [KO:K01027] [EC:2.8.3.5]
65984  Aacs; acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
25014  Acat1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
308100  Acat2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
29637  Hmgcs1; 3-hydroxy-3-methylglutaryl-CoA synthase 1 [KO:K01641] [EC:2.3.3.10]
24450  Hmgcs2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 [KO:K01641] [EC:2.3.3.10]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
KO pathway
ko00280   

DBGET integrated database retrieval system