KEGG   PATHWAY: rno00330
Entry
rno00330                    Pathway                                
Name
Arginine and proline metabolism - Rattus norvegicus (rat)
Class
Metabolism; Amino acid metabolism
Pathway map
rno00330  Arginine and proline metabolism
rno00330

Module
rno_M00015  Proline biosynthesis, glutamate => proline [PATH:rno00330]
rno_M00047  Creatine pathway [PATH:rno00330]
rno_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:rno00330]
rno_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:rno00330]
rno_M00970  Proline degradation, proline => glutamate [PATH:rno00330]
rno_M00972  Proline metabolism [PATH:rno00330]
Other DBs
GO: 0006525 0006560
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
81660  Gatm; glycine amidinotransferase, mitochondrial precursor [KO:K00613] [EC:2.1.4.1]
25257  Gamt; guanidinoacetate N-methyltransferase isoform 2 [KO:K00542] [EC:2.1.1.2]
24264  Ckb; creatine kinase B-type [KO:K00933] [EC:2.7.3.2]
688698  Ckmt2; creatine kinase S-type, mitochondrial precursor [KO:K00933] [EC:2.7.3.2]
29593  Ckmt1; creatine kinase U-type, mitochondrial precursor [KO:K00933] [EC:2.7.3.2]
24265  Ckm; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
366473  Azin2; antizyme inhibitor 2 [KO:K01583] [EC:4.1.1.19]
24609  Odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
297899  Ldc1; antizyme inhibitor 2 [KO:K01581] [EC:4.1.1.17]
84596  Srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
120101528  LOW QUALITY PROTEIN: spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
363469  Sms; spermine synthase [KO:K00802] [EC:2.5.1.22]
498273  Smsl1; spermine synthase-like [KO:K00802] [EC:2.5.1.22]
81640  Amd1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
312316  Doxl1; diamine oxidase-like protein 1 precursor [KO:K11182] [EC:1.4.3.22]
65029  Aoc1; amiloride-sensitive amine oxidase [copper-containing] precursor [KO:K11182] [EC:1.4.3.22]
297081  Svs1; seminal vesicle secretory protein 1 precursor [KO:K11182] [EC:1.4.3.22]
312317  Doxl2; diamine oxidase-like protein 2 precursor [KO:K11182] [EC:1.4.3.22]
308652  Smox; spermine oxidase [KO:K12259] [EC:1.5.3.16 1.5.3.-]
29539  Aldh2; aldehyde dehydrogenase, mitochondrial precursor [KO:K00128] [EC:1.2.1.3]
65183  Aldh3a2; aldehyde dehydrogenase family 3 member A2 [KO:K00128] [EC:1.2.1.3]
298079  Aldh1b1; aldehyde dehydrogenase X, mitochondrial precursor [KO:K00128] [EC:1.2.1.3]
291450  Aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
64040  Aldh9a1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
307212  Cndp1; beta-Ala-His dipeptidase [KO:K05604] [EC:3.4.13.20]
291394  Cndp2; cytosolic non-specific dipeptidase [KO:K08660] [EC:3.4.13.18]
309150  Carns1; carnosine synthase 1 isoform X1 [KO:K14755] [EC:6.3.2.11]
360547  Sat2; thialysine N-epsilon-acetyltransferase [KO:K00657] [EC:2.3.1.57]
302642  Sat1; diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
25750  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
29253  Maoa; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
298607  Agmat; guanidino acid hydrolase, mitochondrial precursor [KO:K27001] [EC:3.5.3.- 3.5.3.7 3.5.3.17]
24598  Nos1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
24599  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
24600  Nos3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
29215  Arg2; arginase-2, mitochondrial precursor [KO:K01476] [EC:3.5.3.1]
29221  Arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
64313  Oat; ornithine aminotransferase, mitochondrial precursor [KO:K00819] [EC:2.6.1.13]
364064  Pycr2; pyrroline-5-carboxylate reductase 2 [KO:K00286] [EC:1.5.1.2]
300035  Pycr3; pyrroline-5-carboxylate reductase 3 [KO:K00286] [EC:1.5.1.2]
287877  Pycr1; pyrroline-5-carboxylate reductase 1, mitochondrial [KO:K00286] [EC:1.5.1.2]
680409  Prodh; proline dehydrogenase 1, mitochondrial [KO:K00318] [EC:1.5.5.2]
641316  Aldh4a1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [KO:K00294] [EC:1.2.1.88]
361755  Aldh18a1; delta-1-pyrroline-5-carboxylate synthase isoform 1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
289668  Lap3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
64475  P4ha1; prolyl 4-hydroxylase subunit alpha-1 precursor [KO:K00472] [EC:1.14.11.2]
361612  P4ha3; prolyl 4-hydroxylase subunit alpha-3 precursor [KO:K00472] [EC:1.14.11.2]
360526  P4ha2; prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor [KO:K00472] [EC:1.14.11.2]
361538  Prodh2; hydroxyproline dehydrogenase [KO:K11394] [EC:1.5.5.3]
24401  Got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
25721  Got2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
293949  Hoga1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial [KO:K18123] [EC:4.1.3.16]
114027  Dao; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
314214  L3hypdh; trans-3-hydroxy-L-proline dehydratase [KO:K18384] [EC:4.2.1.77]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
rno00020  Citrate cycle (TCA cycle)
rno00220  Arginine biosynthesis
rno00250  Alanine, aspartate and glutamate metabolism
rno00260  Glycine, serine and threonine metabolism
rno00270  Cysteine and methionine metabolism
rno00310  Lysine degradation
rno00410  beta-Alanine metabolism
rno00470  D-Amino acid metabolism
rno00480  Glutathione metabolism
rno00630  Glyoxylate and dicarboxylate metabolism
rno00650  Butanoate metabolism
rno00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (54)   
   KEGG GENES (54)   
All databases (55)   

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