KEGG   PATHWAY: rno04010Help
Entry
rno04010                    Pathway                                

Name
MAPK signaling pathway - Rattus norvegicus (rat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
MAPK signaling pathway
rno04010

All organismsOrtholog table
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
25398  
Cacna1a; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [KO:K04344]
257648  
Cacna1b; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849]
24239  
Cacna1c; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
29716  
Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851]
54234  
Cacna1e; calcium channel, voltage-dependent, R type, alpha 1E subunit [KO:K04852]
114493  
Cacna1f; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
29717  
Cacna1g; calcium channel, voltage-dependent, T type, alpha 1G subunit [KO:K04854]
114862  
Cacna1h; calcium channel, voltage-dependent, T type, alpha 1H subunit [KO:K04855]
56827  
Cacna1i; calcium channel, voltage-dependent, T type, alpha 1I subunit [KO:K04856]
682930  
Cacna1s; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857]
25399  
Cacna2d1; calcium channel, voltage-dependent, alpha2/delta subunit 1 [KO:K04858]
300992  
Cacna2d2; calcium channel, voltage-dependent, alpha 2/delta subunit 2 [KO:K04859]
306243  
Cacna2d3; calcium channel, voltage-dependent, alpha2/delta subunit 3 [KO:K04860]
312668  
Cacna2d4; calcium channel, voltage-dependent, alpha 2/delta subunit 4 [KO:K04861]
50688  
Cacnb1; calcium channel, voltage-dependent, beta 1 subunit [KO:K04862]
116600  
Cacnb2; calcium channel, voltage-dependent, beta 2 subunit [KO:K04863]
25297  
Cacnb3; calcium channel, voltage-dependent, beta 3 subunit [KO:K04864]
58942  
Cacnb4; calcium channel, voltage-dependent, beta 4 subunit [KO:K04865]
29658  
Cacng1; calcium channel, voltage-dependent, gamma subunit 1 [KO:K04866]
84347  
Cacng2; calcium channel, voltage-dependent, gamma subunit 2 [KO:K04867]
140724  
Cacng3; calcium channel, voltage-dependent, gamma subunit 3 [KO:K04868]
140725  
Cacng4; calcium channel, voltage-dependent, gamma subunit 4 [KO:K04869]
140726  
Cacng5; calcium channel, voltage-dependent, gamma subunit 5 [KO:K04870]
140727  
Cacng6; calcium channel, voltage-dependent, gamma subunit 6 [KO:K04871]
140728  
Cacng7; calcium channel, voltage-dependent, gamma subunit 7 [KO:K04872]
140729  
Cacng8; calcium channel, voltage-dependent, gamma subunit 8 [KO:K04873]
25636  
Prkaca; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
293508  
Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
501563  
Prkx; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
24680  
Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
24681  
Prkcg; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
25023  
Prkcb; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
81663  
Gna12; guanine nucleotide binding protein (G protein) alpha 12 [KO:K04346]
114120  
Gng12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
685513  
similar to Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-12 subunit precursor; K04347 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
24674  
Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
24675  
Ppp3cb; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
171378  
Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
29748  
Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha [KO:K06268]
29749  
Ppp3r2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
192213  
Rasgrf1; RAS protein-specific guanine nucleotide-releasing factor 1 [KO:K04349]
114513  
Rasgrf2; RAS protein-specific guanine nucleotide-releasing factor 2 [KO:K12326]
29434  
Rasgrp1; RAS guanyl releasing protein 1 (calcium and DAG-regulated) [KO:K04350]
361714  
Rasgrp2; RAS guanyl releasing protein 2 (calcium and DAG-regulated) [KO:K12361]
313874  
Rasgrp3; RAS guanyl releasing protein 3 (calcium and DAG-regulated) [KO:K12362]
170668  
Rasgrp4; RAS guanyl releasing protein 4 [KO:K12363]
310533  
Rapgef2; Rap guanine nucleotide exchange factor (GEF) 2 [KO:K08018]
24592  
Nf1; neurofibromin 1 [KO:K08052]
25676  
Rasa1; RAS p21 protein activator (GTPase activating protein) 1 [KO:K04352]
25597  
Rasa2; RAS p21 protein activator 2 [KO:K08053]
295347  
Rap1a; RAP1A, member of RAS oncogene family [KO:K04353]
171337  
Rap1b; RAP1B, member of RAS oncogene family [KO:K07836]
310738  
Ngf; nerve growth factor (beta polypeptide) [KO:K02582]
24225  
Bdnf; brain-derived neurotrophic factor [KO:K04355]
81737  
Ntf3; neurotrophin 3 [KO:K04356]
25730  
Ntf4; neurotrophin 4 [KO:K12457]
25313  
Egf; epidermal growth factor [KO:K04357]
25317  
Fgf1; fibroblast growth factor 1 (acidic) [KO:K18496]
54250  
Fgf2; fibroblast growth factor 2 [KO:K18497]
170633  
Fgf3; fibroblast growth factor 3 [KO:K04358]
116499  
Fgf4; fibroblast growth factor 4 [KO:K04358]
60662  
Fgf5; fibroblast growth factor 5 [KO:K04358]
170700  
Fgf6; fibroblast growth factor 6 [KO:K04358]
29348  
Fgf7; fibroblast growth factor 7 [KO:K04358]
29349  
Fgf8; fibroblast growth factor 8 [KO:K04358]
25444  
Fgf9; fibroblast growth factor 9 [KO:K04358]
25443  
Fgf10; fibroblast growth factor 10 [KO:K04358]
170632  
Fgf11; fibroblast growth factor 11 [KO:K04358]
170630  
Fgf12; fibroblast growth factor 12 [KO:K04358]
84488  
Fgf13; fibroblast growth factor 13 [KO:K04358]
63851  
Fgf14; fibroblast growth factor 14 [KO:K04358]
60464  
Fgf16; fibroblast growth factor 16 [KO:K04358]
29368  
Fgf17; fibroblast growth factor 17 [KO:K04358]
29369  
Fgf18; fibroblast growth factor 18 [KO:K04358]
170582  
Fgf19; fibroblast growth factor 19 [KO:K04358]
66017  
Fgf20; fibroblast growth factor 20 [KO:K04358]
170580  
Fgf21; fibroblast growth factor 21 [KO:K04358]
170579  
Fgf22; fibroblast growth factor 22 [KO:K04358]
170583  
Fgf23; fibroblast growth factor 23 [KO:K04358]
25266  
Pdgfa; platelet-derived growth factor alpha polypeptide [KO:K04359]
24628  
Pdgfb; platelet-derived growth factor beta polypeptide [KO:K17386]
59109  
Ntrk1; neurotrophic tyrosine kinase, receptor, type 1 [KO:K03176] [EC:2.7.10.1]
25054  
Ntrk2; neurotrophic tyrosine kinase, receptor, type 2 [KO:K04360] [EC:2.7.10.1]
24329  
Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
79114  
Fgfr1; Fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
25022  
Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
84489  
Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
25114  
Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
25267  
Pdgfra; platelet derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
24629  
Pdgfrb; platelet derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
81504  
Grb2; growth factor receptor bound protein 2 [KO:K04364]
85384  
Sos2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
313845  
Sos1; Son of sevenless homolog 1 (Drosophila) [KO:K03099]
293621  
Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
24525  
Kras; Kirsten rat sarcoma viral oncogene [KO:K07827]
24605  
Nras; neuroblastoma ras oncogene [KO:K07828]
361568  
Rras; related RAS viral (r-ras) oncogene homolog [KO:K07829]
365355  
Rras2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
25482  
Mras; muscle RAS oncogene homolog [KO:K07831]
114486  
Braf; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
24703  
Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
24559  
Mos; Moloney sarcoma oncogene [KO:K04367] [EC:2.7.11.1]
170851  
Map2k1; mitogen activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
58960  
Map2k2; mitogen activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
362045  
Lamtor3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
116590  
Mapk1; mitogen activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
50689  
Mapk3; mitogen activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
299618  
Mknk2; MAP kinase-interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
500526  
Mknk1; MAP kinase-interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
81771  
Rps6ka1; ribosomal protein S6 kinase, polypeptide A1 [KO:K04373] [EC:2.7.11.1]
117269  
Rps6ka2; ribosomal protein S6 kinase polypeptide 2 [KO:K04373] [EC:2.7.11.1]
501560  
Rps6ka3; ribosomal protein S6 kinase polypeptide 3 [KO:K04373] [EC:2.7.11.1]
317203  
Rps6ka6; ribosomal protein S6 kinase polypeptide 6 [KO:K04373] [EC:2.7.11.1]
79255  
Atf4; activating transcription factor 4 [KO:K04374]
314436  
Elk1; ELK1, member of ETS oncogene family [KO:K04375]
304786  
Elk4; ELK4, ETS-domain protein (SRF accessory protein 1) [KO:K04376]
24577  
Myc; myelocytomatosis oncogene [KO:K04377]
501099  
Srf; serum response factor (c-fos serum response element-binding transcription factor) [KO:K04378]
314322  
Fos; FBJ osteosarcoma oncogene [KO:K04379]
29477  
Mapt; microtubule-associated protein tau [KO:K04380]
29332  
Stmn1; stathmin 1 [KO:K04381]
303471  
RGD1565395; similar to stathmin 1/oncoprotein 18) [KO:K04381]
296091  
Pla2g4e; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
24653  
Pla2g4a; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342] [EC:3.1.1.4]
311341  
Pla2g4b; phospholipase A2, group IVB (cytosolic) [KO:K16342] [EC:3.1.1.4]
691813  
similar to phospholipase A2; K16342 cytosolic phospholipase A2 [EC:3.1.1.4] [KO:K16342] [EC:3.1.1.4]
691905  
Pla2g4d; phospholipase A2, group IVD (cytosolic) [KO:K16342] [EC:3.1.1.4]
691907  
Pla2g4f; phospholipase A2, group IVF [KO:K16342] [EC:3.1.1.4]
691810  
Pla2g4c; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4]
24835  
Tnf; tumor necrosis factor [KO:K03156]
24493  
Il1a; interleukin 1 alpha [KO:K04383]
24494  
Il1b; interleukin 1 beta [KO:K04519]
59086  
Tgfb1; transforming growth factor, beta 1 [KO:K13375]
81809  
Tgfb2; transforming growth factor, beta 2 [KO:K13376]
25717  
Tgfb3; transforming growth factor, beta 3 [KO:K13377]
25625  
Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158]
25663  
Il1r1; interleukin 1 receptor, type I [KO:K04386]
117022  
Il1r2; interleukin 1 receptor, type II [KO:K04387]
29591  
Tgfbr1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
81810  
Tgfbr2; transforming growth factor, beta receptor 2 [KO:K04388] [EC:2.7.11.30]
25385  
Faslg; Fas ligand (TNF superfamily, member 6) [KO:K04389]
246097  
Fas; Fas cell surface death receptor [KO:K04390]
60350  
Cd14; CD14 molecule [KO:K04391]
363875  
Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
366957  
Rac2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
64465  
Cdc42; cell division cycle 42 [KO:K04393]
25402  
Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
311786  
Traf2; Tnf receptor-associated factor 2 [KO:K03173]
140926  
Daxx; death-domain associated protein [KO:K02308]
311245  
Traf6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
25112  
Gadd45a; growth arrest and DNA-damage-inducible, alpha [KO:K04402]
291005  
Gadd45g; growth arrest and DNA-damage-inducible, gamma [KO:K04402]
299626  
Gadd45b; growth arrest and DNA-damage-inducible, beta [KO:K04402]
315139  
Tab1; TGF-beta activated kinase 1/MAP3K7 binding protein 1 [KO:K04403]
308267  
Tab2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
300447  
Ecsit; ECSIT signalling integrator [KO:K04405]
170920  
Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
301363  
Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
292763  
Map4k1; mitogen activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
29431  
Pak1; p21 protein (Cdc42/Rac)-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
29432  
Pak2; p21 protein (Cdc42/Rac)-activated kinase 2 [KO:K04410] [EC:2.7.11.1]
serine/threonine-protein kinase PAK 2-like; K04410 p21-activated kinase 2 [EC:2.7.11.1] [KO:K04410] [EC:2.7.11.1]
311622  
Stk4; serine/threonine kinase 4 [KO:K04411]
65189  
Stk3; serine/threonine kinase 3 [KO:K04412]
293694  
Map4k2; mitogen activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
116596  
Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
116667  
Map3k1; mitogen activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
309168  
Map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
171492  
Map3k2; mitogen activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
303604  
Map3k3; mitogen activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
303823  
Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
25579  
Map3k12; mitogen activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
311743  
Zak; sterile alpha motif and leucine zipper containing kinase AZK [KO:K04424] [EC:2.7.11.25]
313022  
Map3k6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
365057  
Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
313121  
Map3k7; mitogen activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
mitogen-activated protein kinase kinase kinase 7-like; K04427 mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25] [KO:K04427] [EC:2.7.11.25]
308106  
Map3k4; mitogen activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
64666  
Taok2; TAO kinase 2 [KO:K04429] [EC:2.7.11.1]
286993  
Taok1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
304530  
Taok3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
287398  
Map2k4; mitogen activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
363855  
Map2k7; mitogen activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
303200  
Map2k3; mitogen activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
dual specificity mitogen-activated protein kinase kinase 3-like; K04432 mitogen-activated protein kinase kinase 3 [EC:2.7.12.2] [KO:K04432] [EC:2.7.12.2]
114495  
Map2k6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
116457  
Mapk8ip1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
315220  
Mapk8ip2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
302983  
Mapk8ip3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
306204  
Flnb; filamin B, beta [KO:K04437]
293860  
Flna; filamin A, alpha [KO:K04437]
362332  
Flnc; filamin C, gamma [KO:K04437]
54245  
Crk; v-crk avian sarcoma virus CT10 oncogene homolog [KO:K04438]
287942  
Crkl; v-crk avian sarcoma virus CT10 oncogene homolog-like [KO:K04438]
crk-like protein-like; K04438 proto-oncogene C-crk [KO:K04438]
25387  
Arrb1; arrestin, beta 1 [KO:K04439]
25388  
Arrb2; arrestin, beta 2 [KO:K04439]
25272  
Mapk10; mitogen activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
50658  
Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
116554  
Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
81649  
Mapk14; mitogen activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
60352  
Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
29513  
Mapk13; mitogen activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
689314  
Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
498183  
Mapkapk5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
289014  
Mapkapk2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
315994  
Mapkapk3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
314384  
Rps6ka5; ribosomal protein S6 kinase, polypeptide 5 [KO:K04445] [EC:2.7.11.1]
361715  
Rps6ka4; ribosomal protein S6 kinase, polypeptide 4 [KO:K16510] [EC:2.7.11.1]
171103  
Cdc25b; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
Nfatc1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [KO:K04446]
361400  
Nfatc3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 [KO:K17333]
24516  
Jun; jun proto-oncogene [KO:K04448]
24518  
Jund; jun D proto-oncogene [KO:K04449]
81647  
Atf2; activating transcription factor 2 [KO:K04450]
24842  
Tp53; tumor protein p53 [KO:K04451]
29467  
Ddit3; DNA-damage inducible transcript 3 [KO:K04452]
60661  
Max; MYC associated factor X [KO:K04453]
499497  
Mef2c; myocyte enhancer factor 2C [KO:K04454]
24471  
Hspb1; heat shock protein B1 [KO:K04455]
24185  
Akt1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
25233  
Akt2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
29414  
Akt3; v-akt murine thymoma viral oncogene homolog 3 [KO:K04456] [EC:2.7.11.1]
24666  
Ppm1a; protein phosphatase, Mg2+/Mn2+ dependent, 1A [KO:K04457] [EC:3.1.3.16]
94202  
Ptprr; protein tyrosine phosphatase, receptor type, R [KO:K04458] [EC:3.1.3.48]
29644  
Ptpn5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
246781  
Ptpn7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
114856  
Dusp1; dual specificity phosphatase 1 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
60587  
Dusp4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
116663  
Dusp6; dual specificity phosphatase 6 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
300980  
Dusp7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
171109  
Dusp5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
63995  
Dusp10; dual specificity phosphatase 10 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
297682  
Dusp16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
311406  
Dusp2; dual specificity phosphatase 2 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
361679  
Dusp8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
293847  
Dusp9; dual specificity phosphatase 9 [KO:K18498] [EC:3.1.3.48 3.1.3.16]
498003  
Dusp3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.48 3.1.3.16]
65179  
Ppp5c; protein phosphatase 5, catalytic subunit [KO:K04460] [EC:3.1.3.16]
24667  
Ppm1b; protein phosphatase, Mg2+/Mn2+ dependent, 1B [KO:K04461] [EC:3.1.3.16]
24468  
Hspa8; heat shock 70kDa protein 8 [KO:K03283]
24472  
Hspa1a; heat shock 70kD protein 1A [KO:K03283]
60460  
Hspa2; heat shock protein 2 [KO:K03283]
680121  
similar to heat shock protein 8; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
294254  
Hspa1b; heat shock 70kD protein 1B (mapped) [KO:K03283]
24963  
Hspa1l; heat shock protein 1-like [KO:K03283]
294924  
Mecom; MDS1 and EVI1 complex locus [KO:K04462]
29568  
Map2k5; mitogen activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
114509  
Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
mitogen-activated protein kinase 7-like; K04464 mitogen-activated protein kinase 7 [EC:2.7.11.24] [KO:K04464] [EC:2.7.11.24]
79240  
Nr4a1; nuclear receptor subfamily 4, group A, member 1 [KO:K04465]
360640  
Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
309361  
Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
84351  
Ikbkb; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
309295  
Ikbkg; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
497961  
Nlk; nemo like kinase [KO:K04468] [EC:2.7.11.24]
81736  
Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
309452  
Nfkb2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 [KO:K04469]
309165  
Rela; v-rel avian reticuloendotheliosis viral oncogene homolog A [KO:K04735]
Relb; v-rel avian reticuloendotheliosis viral oncogene homolog B [KO:K09253]
Compound
C00076  
Calcium cation
C00165  
Diacylglycerol
C00338  
Lipopolysaccharide
C00575  
3',5'-Cyclic AMP
C01245  
D-myo-Inositol 1,4,5-trisphosphate
Reference
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
Reference
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
Reference
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
Reference
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
Reference
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
Reference
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
Reference
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
Reference
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
Reference
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
KO pathway
 

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