KEGG   PATHWAY: rno04115Help
Entry
rno04115                    Pathway                                

Name
p53 signaling pathway - Rattus norvegicus (rat)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
p53 signaling pathway
rno04115

All organismsOrtholog table
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
300711  
Atm; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
114212  
Chek2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
685055  
Atr; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
140583  
Chek1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
304923  
Gorab; golgin, RAB6-interacting [KO:K19748]
25163  
Cdkn2a; cyclin-dependent kinase inhibitor 2A [KO:K06621]
314856  
Mdm2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
304798  
Mdm4; MDM4, p53 regulator [KO:K10127]
24842  
Tp53; tumor protein p53 [KO:K04451]
114851  
Cdkn1a; cyclin-dependent kinase inhibitor 1A [KO:K06625]
58919  
Ccnd1; cyclin D1 [KO:K04503]
64033  
Ccnd2; cyclin D2 [KO:K10151]
25193  
Ccnd3; cyclin D3 [KO:K10152]
94201  
Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114483  
Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
362485  
Ccne2; cyclin E2 [KO:K06626]
25729  
Ccne1; cyclin E1 [KO:K06626]
362817  
Cdk2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
313017  
Sfn; stratifin [KO:K06644]
298795  
similar to 14-3-3 protein sigma; K06644 stratifin [KO:K06644]
680110  
Rprm; reprimo, TP53 dependent G2 arrest mediator candidate [KO:K10128]
25203  
Ccnb1; cyclin B1 [KO:K05868]
363088  
Ccnb2; cyclin B2 [KO:K05868]
317389  
Ccnb3; cyclin B3 [KO:K05868]
cyclin B2-like; K05868 cyclin B [KO:K05868]
54237  
Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.23 2.7.11.22]
25112  
Gadd45a; growth arrest and DNA-damage-inducible, alpha [KO:K04402]
291005  
Gadd45g; growth arrest and DNA-damage-inducible, gamma [KO:K04402]
299626  
Gadd45b; growth arrest and DNA-damage-inducible, beta [KO:K04402]
300126  
Gtse1; G-2 and S-phase expressed 1 [KO:K10129]
246097  
Fas; Fas cell surface death receptor [KO:K04390]
293625  
Pidd1; p53-induced death domain protein 1 [KO:K10130]
p53-induced protein with a death domain-like; K10130 leucine-rich repeats and death domain-containing protein [KO:K10130]
64044  
Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
64625  
Bid; BH3 interacting domain death agonist [KO:K04726]
24887  
Bax; BCL2 associated X, apoptosis regulator [KO:K02159]
492821  
Pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
317673  
Bbc3; Bcl-2 binding component 3 [KO:K10132]
300514  
Ei24; EI24, autophagy associated transmembrane protein [KO:K10134]
301013  
Shisa5; shisa family member 5 [KO:K10135]
292949  
Perp; PERP, TP53 apoptosis effector [KO:K10136]
64394  
Zmat3; zinc finger, matrin type 3 [KO:K10137]
140941  
Siah1; siah E3 ubiquitin protein ligase 1 [KO:K04506] [EC:2.3.2.27]
25309  
Cycs; cytochrome c, somatic [KO:K08738]
25310  
Cyct; cytochrome c, testis [KO:K08738]
cytochrome c; K08738 cytochrome c [KO:K08738]
78963  
Apaf1; apoptotic peptidase activating factor 1 [KO:K02084]
58918  
Casp9; caspase 9 [KO:K04399] [EC:3.4.22.62]
25402  
Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
24484  
Igfbp3; insulin-like growth factor binding protein 3 [KO:K10138]
24482  
Igf1; insulin-like growth factor 1 [KO:K05459]
24617  
Serpine1; serpin family E member 1 [KO:K03982]
362931  
Adgrb1; adhesion G protein-coupled receptor B1 [KO:K04596]
83628  
Cd82; Cd82 molecule [KO:K06509]
445442  
Thbs1; thrombospondin 1 [KO:K16857]
116589  
Serpinb5; serpin family B member 5 [KO:K10139]
Ddb2; damage specific DNA binding protein 2 [KO:K10140]
299976  
Rrm2b; ribonucleotide reductase regulatory TP53 inducible subunit M2B [KO:K10808] [EC:1.17.4.1]
362720  
Rrm2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:1.17.4.1]
294518  
Sesn1; sestrin 1 [KO:K10141]
315427  
Sesn3; sestrin 3 [KO:K10141]
502988  
Sesn2; sestrin 2 [KO:K20394]
50557  
Pten; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
24855  
Tsc2; tuberous sclerosis 2 [KO:K07207]
170824  
Steap3; STEAP3 metalloreductase [KO:K10142] [EC:1.16.1.-]
360860  
Rfwd2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase [KO:K10143] [EC:2.3.2.27]
289508  
Rchy1; ring finger and CHY zinc finger domain containing 1 [KO:K10144] [EC:2.3.2.27]
25405  
Ccng1; cyclin G1 [KO:K10145]
29157  
Ccng2; cyclin G2 [KO:K10146]
287585  
Ppm1d; protein phosphatase, Mg2+/Mn2+ dependent, 1D [KO:K10147] [EC:3.1.3.16]
362675  
Tp73; tumor protein p73 [KO:K10148]
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
KO pathway
 

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