KEGG   PATHWAY: rno04144Help
Entry
rno04144                    Pathway                                

Name
Endocytosis - Rattus norvegicus (rat)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Endocytosis
rno04144

All organismsOrtholog table
Module
ESCRT-0 complex [PATH:rno04144]
ESCRT-I complex [PATH:rno04144]
ESCRT-II complex [PATH:rno04144]
ESCRT-III complex [PATH:rno04144]
Other DBs
BSID: 
GO: 
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
59086  
K13375 transforming growth factor beta-1 | (RefSeq) Tgfb1; transforming growth factor, beta 1 [KO:K13375]
81809  
K13376 transforming growth factor beta-2 | (RefSeq) Tgfb2; transforming growth factor, beta 2 [KO:K13376]
25717  
K13377 transforming growth factor beta-3 | (RefSeq) Tgfb3; transforming growth factor, beta 3 [KO:K13377]
29591  
K04674 TGF-beta receptor type-1 [EC:2.7.11.30] | (RefSeq) Tgfbr1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
81810  
K04388 TGF-beta receptor type-2 [EC:2.7.11.30] | (RefSeq) Tgfbr2; transforming growth factor, beta receptor 2 [KO:K04388] [EC:2.7.11.30]
313477  
K04679 MAD; zinc finger FYVE-type containing 9 [KO:K04679]
499508  
K04679 MAD; zinc finger FYVE-type containing 16 [KO:K04679]
315713  
K10054 probable transcription factor PML | (RefSeq) Pml; promyelocytic leukemia [KO:K10054]
25631  
K04500 mothers against decapentaplegic homolog 2/3 | (RefSeq) Smad3; SMAD family member 3 [KO:K04500]
29357  
K04500 mothers against decapentaplegic homolog 2/3 | (RefSeq) Smad2; SMAD family member 2 [KO:K04500]
64678  
K06503 transferrin receptor | (RefSeq) Tfrc; transferrin receptor [KO:K06503]
24329  
K04361 epidermal growth factor receptor [EC:2.7.10.1] | (RefSeq) Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
54251  
K05096 FMS-like tyrosine kinase 1 [EC:2.7.10.1] | (RefSeq) Flt1; FMS-related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
25589  
K05098 kinase insert domain protein receptor [EC:2.7.10.1] | (RefSeq) Kdr; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
25267  
K04363 platelet-derived growth factor receptor alpha [EC:2.7.10.1] | (RefSeq) Pdgfra; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
25022  
K05093 fibroblast growth factor receptor 2 [EC:2.7.10.1] | (RefSeq) Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
84489  
K05094 fibroblast growth factor receptor 3 [EC:2.7.10.1] | (RefSeq) Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
25114  
K05095 fibroblast growth factor receptor 4 [EC:2.7.10.1] | (RefSeq) Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
25718  
K05087 insulin-like growth factor 1 receptor [EC:2.7.10.1] | (RefSeq) Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
24553  
K05099 proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] | (RefSeq) Met; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
59109  
K03176 neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1] | (RefSeq) Ntrk1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
29496  
K05084 receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1] | (RefSeq) Erbb3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
59323  
K05085 receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1] | (RefSeq) Erbb4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
64030  
K05091 proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1] | (RefSeq) Kit; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
24716  
K05126 proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1] | (RefSeq) Ret; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
307403  
K05090 macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1] | (RefSeq) Csf1r; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
25313  
K04357 epidermal growth factor | (RefSeq) Egf; epidermal growth factor [KO:K04357]
140694  
K01528 dynamin GTPase [EC:3.6.5.5] | (RefSeq) Dnm1; dynamin 1 [KO:K01528] [EC:3.6.5.5]
25751  
K01528 dynamin GTPase [EC:3.6.5.5] | (RefSeq) Dnm2; dynamin 2 [KO:K01528] [EC:3.6.5.5]
171574  
K01528 dynamin GTPase [EC:3.6.5.5] | (RefSeq) Dnm3; dynamin 3 [KO:K01528] [EC:3.6.5.5]
79121  
K07941 ADP-ribosylation factor 6 | (RefSeq) Arf6; ADP-ribosylation factor 6 [KO:K07941]
309419  
K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68] | (RefSeq) Pip5k1b; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
314641  
K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68] | (RefSeq) Pip5k1c; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
365865  
K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68] | (RefSeq) Pip5k1a; phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha [KO:K00889] [EC:2.7.1.68]
687758  
K13712 phosphatidylinositol-4-phosphate 5-kinase-like protein 1 [EC:2.7.1.68] | (RefSeq) Pip5kl1; phosphatidylinositol-4-phosphate 5-kinase-like 1 [KO:K13712] [EC:2.7.1.68]
25097  
K01115 phospholipase D1/2 [EC:3.1.4.4] | (RefSeq) Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
25096  
K01115 phospholipase D1/2 [EC:3.1.4.4] | (RefSeq) Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
83800  
K04644 clathrin light chain A | (RefSeq) Clta; clathrin, light chain A [KO:K04644]
116561  
K04645 clathrin light chain B | (RefSeq) Cltb; clathrin, light chain B [KO:K04645]
54241  
K04646 clathrin heavy chain | (RefSeq) Cltc; clathrin heavy chain [KO:K04646]
81637  
K11824 AP-2 complex subunit alpha | (RefSeq) Ap2a2; adaptor-related protein complex 2, alpha 2 subunit [KO:K11824]
308578  
K11824 AP-2 complex subunit alpha | (RefSeq) Ap2a1; adaptor-related protein complex 2, alpha 1 subunit [KO:K11824]
140670  
K11825 AP-2 complex subunit beta-1 | (RefSeq) Ap2b1; adaptor-related protein complex 2, beta 1 subunit [KO:K11825]
116563  
K11826 AP-2 complex subunit mu-1 | (RefSeq) Ap2m1; adaptor-related protein complex 2, mu 1 subunit [KO:K11826]
65046  
K11827 AP-2 complex subunit sigma-1 | (RefSeq) Ap2s1; adaptor-related protein complex 2, sigma 1 subunit [KO:K11827]
361512  
K12469 EH domain-containing protein 2 | (RefSeq) Ehd2; EH-domain containing 2 [KO:K12469]
292699  
K04707 E3 ubiquitin-protein ligase CBL [EC:2.3.2.27] | (RefSeq) Cblc; Cbl proto-oncogene C [KO:K04707] [EC:2.3.2.27]
171136  
K04707 E3 ubiquitin-protein ligase CBL [EC:2.3.2.27] | (RefSeq) Cblb; Cbl proto-oncogene B [KO:K04707] [EC:2.3.2.27]
500985  
K04707 E3 ubiquitin-protein ligase CBL [EC:2.3.2.27] | (RefSeq) Cbl; Cbl proto-oncogene [KO:K04707] [EC:2.3.2.27]
25489  
K10591 E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26] | (RefSeq) Nedd4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:2.3.2.26]
291553  
K13305 E3 ubiquitin-protein ligase NEDD4-like [EC:2.3.2.26] | (RefSeq) Nedd4l; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:2.3.2.26]
314856  
K06643 E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27] | (RefSeq) Mdm2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
311245  
K03175 TNF receptor-associated factor 6 [EC:2.3.2.27] | (RefSeq) Traf6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
362814  
K11981 E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27] | (RefSeq) Rnf41; ring finger protein 41 [KO:K11981] [EC:2.3.2.27]
311567  
K05632 atrophin-1 interacting protein 4 [EC:2.3.2.26] | (RefSeq) Itch; itchy E3 ubiquitin protein ligase [KO:K05632] [EC:2.3.2.26]
303614  
K04678 E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26] | (RefSeq) Smurf2; SMAD specific E3 ubiquitin protein ligase 2 [KO:K04678] [EC:2.3.2.26]
690516  
K04678 E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26] | (RefSeq) Smurf1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:2.3.2.26]
297930  
K05633 atrophin-1 interacting protein 5 (WW domain containing E3 ubiquitin protein ligase 1) [EC:2.3.2.26] | (RefSeq) Wwp1; WW domain containing E3 ubiquitin protein ligase 1 [KO:K05633] [EC:2.3.2.26]
84357  
K12470 SH3 domain-containing kinase-binding protein 1 | (RefSeq) Sh3kbp1; SH3 domain-containing kinase-binding protein 1 [KO:K12470]
81921  
K11247 endophilin-A | (RefSeq) Sh3gl3; SH3 domain-containing GRB2-like 3 [KO:K11247]
116743  
K11247 endophilin-A | (RefSeq) Sh3gl2; SH3 domain-containing GRB2-like 2 [KO:K11247]
81922  
K11247 endophilin-A | (RefSeq) Sh3gl1; SH3 domain-containing GRB2-like 1 [KO:K11247]
292156  
K11248 endophilin-B | (RefSeq) Sh3glb1; SH3 domain -containing GRB2-like endophilin B1 [KO:K11248]
311848  
K11248 endophilin-B | (RefSeq) Sh3glb2; SH3 domain-containing GRB2-like endophilin B2 [KO:K11248]
60668  
K12562 amphiphysin | (RefSeq) Amph; amphiphysin [KO:K12562]
117028  
K12562 amphiphysin | (RefSeq) Bin1; bridging integrator 1 [KO:K12562]
117277  
K12471 epsin | (RefSeq) Epn1; Epsin 1 [KO:K12471]
360605  
K12471 epsin | (RefSeq) Epn3; epsin 3 [KO:K12471]
60443  
K12471 epsin | (RefSeq) Epn2; epsin 2 [KO:K12471]
313474  
K12472 epidermal growth factor receptor substrate 15 | (RefSeq) Eps15; epidermal growth factor receptor pathway substrate 15 [KO:K12472]
361120  
K12472 epidermal growth factor receptor substrate 15 | (RefSeq) Eps15l1; epidermal growth factor receptor pathway substrate 15-like 1 [KO:K12472]
295053  
K19366 spartin | (RefSeq) Spg20; spastic paraplegia 20 (Troyer syndrome) [KO:K19366]
300438  
K12473 low-density lipoprotein receptor | (RefSeq) Ldlr; low density lipoprotein receptor [KO:K12473]
500564  
K12474 low density lipoprotein receptor adapter protein 1 | (RefSeq) Ldlrap1; low density lipoprotein receptor adaptor protein 1 [KO:K12474]
79128  
K12475 disabled homolog 2 | (RefSeq) Dab2; DAB2, clathrin adaptor protein [KO:K12475]
117029  
K04180 C-C chemokine receptor type 5 | (RefSeq) Ccr5; chemokine (C-C motif) receptor 5 [KO:K04180]
54258  
K04175 C-X-C chemokine receptor type 1 | (RefSeq) Cxcr1; C-X-C motif chemokine receptor 1 [KO:K04175]
29385  
K05050 C-X-C chemokine receptor type 2 | (RefSeq) Cxcr2; C-X-C motif chemokine receptor 2 [KO:K05050]
60628  
K04189 C-X-C chemokine receptor type 4 | (RefSeq) Cxcr4; C-X-C motif chemokine receptor 4 [KO:K04189]
25439  
K03914 coagulation factor II (thrombin) receptor | (RefSeq) F2r; coagulation factor II (thrombin) receptor [KO:K03914]
24925  
K04141 adrenergic receptor beta-1 | (RefSeq) Adrb1; adrenoceptor beta 1 [KO:K04141]
24176  
K04142 adrenergic receptor beta-2 | (RefSeq) Adrb2; adrenoceptor beta 2 [KO:K04142]
25645  
K04143 adrenergic receptor beta-3 | (RefSeq) Adrb3; adrenoceptor beta 3 [KO:K04143]
81760  
K00909 rhodopsin kinase [EC:2.7.11.14] | (RefSeq) Grk1; G protein-coupled receptor kinase 1 [KO:K00909] [EC:2.7.11.14]
25238  
K00910 beta-adrenergic-receptor kinase [EC:2.7.11.15] | (RefSeq) Grk2; G protein-coupled receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
25372  
K00910 beta-adrenergic-receptor kinase [EC:2.7.11.15] | (RefSeq) Grk3; G protein-coupled receptor kinase 3 [KO:K00910] [EC:2.7.11.15]
59075  
K08291 G protein-coupled receptor kinase [EC:2.7.11.16] | (RefSeq) Grk5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
59076  
K08291 G protein-coupled receptor kinase [EC:2.7.11.16] | (RefSeq) Grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
59077  
K08291 G protein-coupled receptor kinase [EC:2.7.11.16] | (RefSeq) Grk4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
25387  
K04439 beta-arrestin | (RefSeq) Arrb1; arrestin, beta 1 [KO:K04439]
25388  
K04439 beta-arrestin | (RefSeq) Arrb2; arrestin, beta 2 [KO:K04439]
317371  
K05747 Wiskott-Aldrich syndrome protein | (RefSeq) Was; Wiskott-Aldrich syndrome [KO:K05747]
682507  
K05747 Wiskott-Aldrich syndrome protein | (RefSeq) Wasl; Wiskott-Aldrich syndrome-like [KO:K05747]
54227  
K05757 actin related protein 2/3 complex; actin related protein 2/3 complex, subunit 1B [KO:K05757]
81824  
K05757 actin related protein 2/3 complex; actin related protein 2/3 complex, subunit 1A [KO:K05757]
301511  
K05758 actin related protein 2/3 complex; actin related protein 2/3 complex, subunit 2 [KO:K05758]
288669  
K05756 actin related protein 2/3 complex; actin related protein 2/3 complex, subunit 3 [KO:K05756]
297518  
K05755 actin related protein 2/3 complex; actin related protein 2/3 complex, subunit 4 [KO:K05755]
296710  
K05754 actin related protein 2/3 complex; actin related protein 2/3 complex, subunit 5-like [KO:K05754]
360854  
K05754 actin related protein 2/3 complex; actin related protein 2/3 complex, subunit 5 [KO:K05754]
117538  
K19475 WAS/WASL-interacting protein | (RefSeq) Wipf1; WAS/WASL interacting protein family, member 1 [KO:K19475]
360620  
K19475 WAS/WASL-interacting protein | (RefSeq) Wipf2; WAS/WASL interacting protein family, member 2 [KO:K19475]
259242  
K19475 WAS/WASL-interacting protein | (RefSeq) Wipf3; WAS/WASL interacting protein family, member 3 [KO:K19475]
24468  
K03283 heat shock 70kDa protein 1/8 | (RefSeq) Hspa8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
24472  
K03283 heat shock 70kDa protein 1/8 | (RefSeq) Hspa1a; heat shock 70kD protein 1A [KO:K03283]
60460  
K03283 heat shock 70kDa protein 1/8 | (RefSeq) Hspa2; heat shock protein family A member 2 [KO:K03283]
294254  
K03283 heat shock 70kDa protein 1/8 | (RefSeq) Hspa1b; heat shock 70kD protein 1B (mapped) [KO:K03283]
24963  
K03283 heat shock 70kDa protein 1/8 | (RefSeq) Hspa1l; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
313409  
K09526 DnaJ homolog subfamily C member 6 | (RefSeq) Dnajc6; DnaJ heat shock protein family (Hsp40) member C6 [KO:K09526]
314690  
K18465 WASH complex subunit 7 | (RefSeq) RGD1309995; similar to CG13957-PA [KO:K18465]
362919  
K18464 WASH complex subunit strumpellin | (RefSeq) RGD1564420; similar to Hypothetical protein MGC31278 [KO:K18464]
297530  
K18462 WASH complex subunit FAM21 | (RefSeq) Fam21c; family with sequence similarity 21, member C [KO:K18462]
367328  
K18461 WAS protein family homolog 1 | (RefSeq) Wash1; WAS protein family homolog 1 [KO:K18461]
299707  
K18463 WASH complex subunit CCDC53 | (RefSeq) Ccdc53; coiled-coil domain containing 53 [KO:K18463]
29324  
K10364 capping protein (actin filament) muscle Z-line; capping actin protein of muscle Z-line alpha subunit 3 [KO:K10364]
493810  
K10364 capping protein (actin filament) muscle Z-line; capping actin protein of muscle Z-line alpha subunit 2 [KO:K10364]
691149  
K10364 capping protein (actin filament) muscle Z-line; capping actin protein of muscle Z-line alpha subunit 1 [KO:K10364]
298584  
K10365 capping protein (actin filament) muscle Z-line; capping actin protein of muscle Z-line beta subunit [KO:K10365]
288666  
K18467 vacuolar protein sorting-associated protein 29 | (RefSeq) Vps29; VPS29 retromer complex component [KO:K18467]
300472  
K18466 vacuolar protein sorting-associated protein 26 | (RefSeq) Vps26b; VPS26 retromer complex component B [KO:K18466]
361846  
K18466 vacuolar protein sorting-associated protein 26 | (RefSeq) Vps26a; VPS26 retromer complex component A [KO:K18466]
25479  
K18468 vacuolar protein sorting-associated protein 35 | (RefSeq) Vps35; VPS35 retromer complex component [KO:K18468]
363478  
K17918 sorting nexin-3/12 | (RefSeq) Snx12; sorting nexin 12 [KO:K17918]
684097  
K17918 sorting nexin-3/12 | (RefSeq) Snx3; sorting nexin 3 [KO:K17918]
296121  
K11839 ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12] | (RefSeq) Usp8; ubiquitin specific peptidase 8 [KO:K11839] [EC:3.4.19.12]
171565  
K11866 STAM-binding protein [EC:3.4.19.12] | (RefSeq) Stambp; Stam binding protein [KO:K11866] [EC:3.4.19.12]
29448  
K07897 Ras-related protein Rab-7A | (RefSeq) Rab7a; RAB7A, member RAS oncogene family [KO:K07897]
56084  
K12182 hepatocyte growth factor-regulated tyrosine kinase substrate | (RefSeq) Hgs; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
311030  
K04705 signal transducing adaptor molecule | (RefSeq) Stam2; signal transducing adaptor molecule 2 [KO:K04705]
498798  
K04705 signal transducing adaptor molecule | (RefSeq) Stam; signal transducing adaptor molecule [KO:K04705]
292925  
K12183 ESCRT-I complex subunit TSG101 | (RefSeq) Tsg101; tumor susceptibility 101 [KO:K12183]
290635  
K12186 ESCRT-I complex subunit MVB12 | (RefSeq) Mvb12a; multivesicular body subunit 12A [KO:K12186]
362118  
K12186 ESCRT-I complex subunit MVB12 | (RefSeq) Mvb12b; multivesicular body subunit 12B [KO:K12186]
300052  
K12184 ESCRT-I complex subunit VPS28 | (RefSeq) Vps28; VPS28, ESCRT-I subunit [KO:K12184]
687208  
K12185 ESCRT-I complex subunit VPS37 | (RefSeq) Vps37d; VPS37D, ESCRT-I subunit [KO:K12185]
288659  
K12185 ESCRT-I complex subunit VPS37 | (RefSeq) Vps37b; VPS37B, ESCRT-I subunit [KO:K12185]
308178  
K12185 ESCRT-I complex subunit VPS37 | (RefSeq) Vps37c; VPS37C, ESCRT-I subunit [KO:K12185]
290775  
K12185 ESCRT-I complex subunit VPS37 | (RefSeq) Vps37a; VPS37A, ESCRT-I subunit [KO:K12185]
287645  
K12188 ESCRT-II complex subunit VPS22 | (RefSeq) Snf8; SNF8, ESCRT-II complex subunit [KO:K12188]
290851  
K12190 ESCRT-II complex subunit VPS36 | (RefSeq) Vps36; vacuolar protein sorting 36 [KO:K12190]
681059  
K12189 ESCRT-II complex subunit VPS25 | (RefSeq) Vps25; vacuolar protein sorting 25 [KO:K12189]
287873  
K12195 charged multivesicular body protein 6 | (RefSeq) Chmp6; charged multivesicular body protein 6 [KO:K12195]
679886  
K12194 charged multivesicular body protein 4 | (RefSeq) Chmp4bl1; chromatin modifying protein 4B-like 1 [KO:K12194]
361916  
K12194 charged multivesicular body protein 4 | (RefSeq) Chmp4c; charged multivesicular body protein 4C [KO:K12194]
282834  
K12193 charged multivesicular body protein 3 | (RefSeq) Chmp3; charged multivesicular body protein 3 [KO:K12193]
365191  
K12191 charged multivesicular body protein 2A | (RefSeq) Chmp2a; charged multivesicular body protein 2A [KO:K12191]
363720  
K12192 charged multivesicular body protein 2B | (RefSeq) Chmp2b; charged multivesicular body protein 2B [KO:K12192]
364419  
K15053 charged multivesicular body protein 7 | (RefSeq) Chmp7; charged multivesicular body protein 7 [KO:K15053]
360834  
K12196 vacuolar protein-sorting-associated protein 4 | (RefSeq) Vps4b; vacuolar protein sorting 4 homolog B [KO:K12196]
246772  
K12196 vacuolar protein-sorting-associated protein 4 | (RefSeq) Vps4a; vacuolar protein sorting 4 homolog A [KO:K12196]
292640  
K12199 vacuolar protein sorting-associated protein VTA1 | (RefSeq) Vta1; vesicle trafficking 1 [KO:K12199]
689364  
K12197 charged multivesicular body protein 1 | (RefSeq) Chmp1b; charged multivesicular body protein 1B [KO:K12197]
363487  
K12197 charged multivesicular body protein 1 | (RefSeq) RGD1566265; similar to RIKEN cDNA 2610002M06 [KO:K12197]
365024  
K12197 charged multivesicular body protein 1 | (RefSeq) Chmp1a; charged multivesicular body protein 1A [KO:K12197]
297995  
K12198 charged multivesicular body protein 5 | (RefSeq) Chmp5; charged multivesicular body protein 5 [KO:K12198]
307833  
K19476 vacuolar protein sorting-associated protein IST1 | (RefSeq) Ist1; IST1, ESCRT-III associated factor [KO:K19476]
501083  
K12200 programmed cell death 6-interacting protein | (RefSeq) Pdcd6ip; programmed cell death 6 interacting protein [KO:K12200]
300791  
K19367 maspardin | (RefSeq) Spg21; spastic paraplegia 21 homolog (human) [KO:K19367]
25151  
K06564 insulin-like growth factor 2 receptor | (RefSeq) Igf2r; insulin-like growth factor 2 receptor [KO:K06564]
291464  
K17917 sorting nexin-1/2 | (RefSeq) Snx2; sorting nexin 2 [KO:K17917]
84471  
K17917 sorting nexin-1/2 | (RefSeq) Snx1; sorting nexin 1 [KO:K17917]
296199  
K17920 sorting nexin-5/6/32 | (RefSeq) Snx5; sorting nexin 5 [KO:K17920]
361708  
K17920 sorting nexin-5/6/32 | (RefSeq) Snx32; sorting nexin 32 [KO:K17920]
362738  
K17920 sorting nexin-5/6/32 | (RefSeq) Snx6; sorting nexin 6 [KO:K17920]
83805  
K05704 tyrosine-protein kinase Src [EC:2.7.10.2] | (RefSeq) Src; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
293621  
K02833 GTPase HRas | (RefSeq) Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
25704  
K05068 interleukin 2 receptor alpha | (RefSeq) Il2ra; interleukin 2 receptor subunit alpha [KO:K05068]
25746  
K05069 interleukin 2 receptor beta | (RefSeq) Il2rb; interleukin 2 receptor subunit beta [KO:K05069]
140924  
K05070 interleukin 2 receptor gamma | (RefSeq) Il2rg; interleukin 2 receptor subunit gamma [KO:K05070]
117273  
K04513 Ras homolog gene family; ras homolog family member A [KO:K04513]
297173  
K04513 Ras homolog gene family; RSA-14-44 protein [KO:K04513]
24737  
K06751 major histocompatibility complex; RT1 class Ib, locus EC2 [KO:K06751]
24747  
K06751 major histocompatibility complex; RT1 class Ib, locus M3, gene 1 [KO:K06751]
24748  
K06751 major histocompatibility complex; RT1 class Ib, locus N1 [KO:K06751]
24750  
K06751 major histocompatibility complex; RT1 class Ib, locus N3 [KO:K06751]
24973  
K06751 major histocompatibility complex; RT1 class Ia, locus A1 [KO:K06751]
24974  
K06751 major histocompatibility complex; RT1 class Ia, locus A2 [KO:K06751]
24977  
K06751 major histocompatibility complex; RT1 class Ib, locus Cl [KO:K06751]
24988  
K06751 major histocompatibility complex; RT1 class Ib, locus M2 [KO:K06751]
294213  
K06751 major histocompatibility complex; RT1 class I, locus M1, gene 4 [KO:K06751]
309600  
K06751 major histocompatibility complex; RT1 class I, locus CE12 [KO:K06751]
309603  
K06751 major histocompatibility complex; RT1 class I, locus1 [KO:K06751]
309607  
K06751 major histocompatibility complex; RT1 class I, locus CE5 [KO:K06751]
309627  
K06751 major histocompatibility complex; RT1 class I, locus A3 [KO:K06751]
361787  
K06751 major histocompatibility complex; RT1 class I, locus T24, gene 1 [KO:K06751]
365527  
K06751 major histocompatibility complex; RT1 class I, locus M6, gene 2 [KO:K06751]
368153  
K06751 major histocompatibility complex; RT1 class I, locus CE7 [KO:K06751]
414270  
K06751 major histocompatibility complex; RT1 class I, locus CE14 [KO:K06751]
414779  
K06751 major histocompatibility complex; RT1 class I, locus CE2 [KO:K06751]
414783  
K06751 major histocompatibility complex; RT1 class I, locus CE4 [KO:K06751]
414784  
K06751 major histocompatibility complex; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  
K06751 major histocompatibility complex; RT1 class I, locus M6, gene 1 [KO:K06751]
414786  
K06751 major histocompatibility complex; RT1 class I, locus M1, gene 2 [KO:K06751]
414787  
K06751 major histocompatibility complex; RT1 class I, locus M10, gene 1 [KO:K06751]
414789  
K06751 major histocompatibility complex; RT1 class I, locus CE15 [KO:K06751]
414790  
K06751 major histocompatibility complex; RT1 class I, locus CE13 [KO:K06751]
414791  
K06751 major histocompatibility complex; RT1 class I, locus CE11 [KO:K06751]
414792  
K06751 major histocompatibility complex; RT1 class I, locus CE10 [KO:K06751]
414793  
K06751 major histocompatibility complex; RT1 class I, locus CE3 [KO:K06751]
414819  
K06751 major histocompatibility complex; RT1 class I, locus CE16 [KO:K06751]
24751  
K06751 major histocompatibility complex; RT1 class Ib, locus O1 [KO:K06751]
406194  
K06751 major histocompatibility complex; RT1 class Ib, locus T18 [KO:K06751]
294228  
K06751 major histocompatibility complex; RT1 class Ib, locus S3 [KO:K06751]
309584  
K06751 major histocompatibility complex; RT1 class Ib, locus M4 [KO:K06751]
360323  
K06751 major histocompatibility complex; RT1 class Ib, locus N2 [KO:K06751]
K06751 major histocompatibility complex; RT1 class I, locus A [KO:K06751]
414788  
K06751 major histocompatibility complex; RT1 class I, locus T24, gene 3 [KO:K06751]
680842  
K06751 major histocompatibility complex; RT1 class I, M1, gene 5 [KO:K06751]
K06751 major histocompatibility complex [KO:K06751]
499400  
K06751 major histocompatibility complex; RT1 class Ib, locus M5 [KO:K06751]
171049  
K13649 folate receptor | (RefSeq) Folr1; folate receptor 1 [KO:K13649]
293154  
K13649 folate receptor | (RefSeq) Folr2; folate receptor beta [KO:K13649]
690037  
K13649 folate receptor | (RefSeq) Izumo1r; IZUMO1 receptor, JUNO [KO:K13649]
25404  
K06278 caveolin 1 | (RefSeq) Cav1; caveolin 1 [KO:K06278]
363425  
K12958 caveolin 2 | (RefSeq) Cav2; caveolin 2 [KO:K12958]
29161  
K12959 caveolin 3 | (RefSeq) Cav3; caveolin 3 [KO:K12959]
192249  
K12476 EH domain-containing protein 3 | (RefSeq) Ehd3; EH-domain containing 3 [KO:K12476]
192204  
K12477 EH domain-containing protein 4 | (RefSeq) Ehd4; EH-domain containing 4 [KO:K12477]
314764  
K12478 early endosome antigen 1 | (RefSeq) Eea1; early endosome antigen 1 [KO:K12478]
64633  
K07887 Ras-related protein Rab-5A | (RefSeq) Rab5a; RAB5A, member RAS oncogene family [KO:K07887]
K07887 Ras-related protein Rab-5A | (RefSeq) Rab5al1; Rab5a, member RAS oncogene family-like 1 [KO:K07887]
288779  
K07888 Ras-related protein Rab-5B | (RefSeq) Rab5b; RAB5B, member RAS oncogene family [KO:K07888]
287709  
K07889 Ras-related protein Rab-5C | (RefSeq) Rab5c; RAB5C, member RAS oncogene family [KO:K07889]
54190  
K12480 Rab GTPase-binding effector protein 1 | (RefSeq) Rabep1; rabaptin, RAB GTPase binding effector protein 1 [KO:K12480]
312562  
K12481 rabenosyn-5 | (RefSeq) Rbsn; rabenosyn, RAB effector [KO:K12481]
25532  
K07879 Ras-related protein Rab-4A | (RefSeq) Rab4a; RAB4A, member RAS oncogene family [KO:K07879]
360521  
K12482 RUN and FYVE domain-containing protein 1 | (RefSeq) Rufy1; RUN and FYVE domain containing 1 [KO:K12482]
293692  
K12483 EH domain-containing protein 1 | (RefSeq) Ehd1; EH-domain containing 1 [KO:K12483]
64516  
K12479 vacuolar protein sorting-associated protein 45 | (RefSeq) Vps45; vacuolar protein sorting 45 [KO:K12479]
360725  
K17919 sorting nexin-4 | (RefSeq) Snx4; sorting nexin 4 [KO:K17919]
366265  
K07891 Ras-related protein Rab-22 | (RefSeq) Rab22a; RAB22A, member RAS oncogene family [KO:K07891]
246324  
K07891 Ras-related protein Rab-22 | (RefSeq) Rab31; RAB31, member RAS oncogene family [KO:K07891]
50993  
K07903 Ras-related protein Rab-10 | (RefSeq) Rab10; RAB10, member RAS oncogene family [KO:K07903]
117103  
K07901 Ras-related protein Rab-8A | (RefSeq) Rab8a; RAB8A, member RAS oncogene family [KO:K07901]
288700  
K07876 Ras-related protein Rab-35 | (RefSeq) Rab35; RAB35, member RAS oncogene family [KO:K07876]
81830  
K07904 Ras-related protein Rab-11A | (RefSeq) Rab11a; RAB11a, member RAS oncogene family [KO:K07904]
79434  
K07905 Ras-related protein Rab-11B | (RefSeq) Rab11b; RAB11B, member RAS oncogene family [KO:K07905]
308003  
K12484 Rab11 family-interacting protein 1/2/5 | (RefSeq) Rab11fip2; RAB11 family interacting protein 2 [KO:K12484]
498650  
K12484 Rab11 family-interacting protein 1/2/5 | (RefSeq) Rab11fip1; RAB11 family interacting protein 1 [KO:K12484]
312502  
K12484 Rab11 family-interacting protein 1/2/5 | (RefSeq) Rab11fip5; RAB11 family interacting protein 5 [KO:K12484]
309376  
K19368 protrudin | (RefSeq) Zfyve27; zinc finger FYVE-type containing 27 [KO:K19368]
117550  
K10396 kinesin family member 5 | (RefSeq) Kif5b; kinesin family member 5B [KO:K10396]
311024  
K10396 kinesin family member 5 | (RefSeq) Kif5c; kinesin family member 5C [KO:K10396]
314906  
K10396 kinesin family member 5 | (RefSeq) Kif5a; kinesin family member 5A [KO:K10396]
303337  
K12485 Rab11 family-interacting protein 3/4 | (RefSeq) Rab11fip4; RAB11 family interacting protein 4 [KO:K12485]
303002  
K12485 Rab11 family-interacting protein 3/4 | (RefSeq) Rab11fip3; RAB11 family interacting protein 3 [KO:K12485]
81918  
K04237 partitioning defective protein 3 | (RefSeq) Pard3; par-3 family cell polarity regulator [KO:K04237]
307237  
K06093 partitioning defective protein 6 | (RefSeq) Pard6g; par-6 family cell polarity regulator gamma [KO:K06093]
307799  
K06093 partitioning defective protein 6 | (RefSeq) Pard6a; par-6 family cell polarity regulator alpha [KO:K06093]
362279  
K06093 partitioning defective protein 6 | (RefSeq) Pard6b; par-6 family cell polarity regulator beta [KO:K06093]
25522  
K18952 atypical protein kinase C zeta type [EC:2.7.11.13] | (RefSeq) Prkcz; protein kinase C, zeta [KO:K18952] [EC:2.7.11.13]
84006  
K06069 atypical protein kinase C iota type [EC:2.7.11.13] | (RefSeq) Prkci; protein kinase C, iota [KO:K06069] [EC:2.7.11.13]
64465  
K04393 cell division control protein 42 | (RefSeq) Cdc42; cell division cycle 42 [KO:K04393]
298500  
K12486 stromal membrane-associated protein | (RefSeq) Smap2; small ArfGAP2 [KO:K12486]
684800  
K12486 stromal membrane-associated protein | (RefSeq) Smap1; small ArfGAP 1 [KO:K12486]
83709  
K05737 G protein-coupled receptor kinase interactor 1 | (RefSeq) Git1; GIT ArfGAP 1 [KO:K05737]
304546  
K12487 G protein-coupled receptor kinase interactor 2 | (RefSeq) Git2; GIT ArfGAP 2 [KO:K12487]
684122  
K12488 Arf-GAP with SH3 domain; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [KO:K12488]
314961  
K12488 Arf-GAP with SH3 domain; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [KO:K12488]
362719  
K12488 Arf-GAP with SH3 domain; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [KO:K12488]
313772  
K12489 Arf-GAP with coiled-coil; ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [KO:K12489]
619382  
K12489 Arf-GAP with coiled-coil; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [KO:K12489]
287443  
K12489 Arf-GAP with coiled-coil; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [KO:K12489]
361617  
K18439 Arf-GAP with Rho-GAP domain; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [KO:K18439]
305367  
K18440 Arf-GAP with Rho-GAP domain; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [KO:K18440]
361314  
K12490 Arf-GAP with Rho-GAP domain; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490]
316611  
K12491 Arf-GAP with GTPase; ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [KO:K12491]
362300  
K12491 Arf-GAP with GTPase; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [KO:K12491]
65218  
K17848 Arf-GAP with GTPase; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [KO:K17848]
246310  
K12492 ADP-ribosylation factor GTPase-activating protein 1 | (RefSeq) Arfgap1; ADP-ribosylation factor GTPase activating protein 1 [KO:K12492]
362162  
K12493 ADP-ribosylation factor GTPase-activating protein 2/3 | (RefSeq) Arfgap2; ADP-ribosylation factor GTPase activating protein 2 [KO:K12493]
503165  
K12493 ADP-ribosylation factor GTPase-activating protein 2/3 | (RefSeq) Arfgap3; ADP-ribosylation factor GTPase activating protein 3 [KO:K12493]
171381  
K12494 PH and SEC7 domain-containing protein | (RefSeq) Psd; pleckstrin and Sec7 domain containing [KO:K12494]
306380  
K12494 PH and SEC7 domain-containing protein | (RefSeq) Psd3; pleckstrin and Sec7 domain containing 3 [KO:K12494]
307500  
K12494 PH and SEC7 domain-containing protein | (RefSeq) Psd2; pleckstrin and Sec7 domain containing 2 [KO:K12494]
311785  
K12494 PH and SEC7 domain-containing protein | (RefSeq) Psd4; pleckstrin and Sec7 domain containing 4 [KO:K12494]
686590  
K12495 IQ motif and SEC7 domain-containing protein | (RefSeq) Iqsec1; IQ motif and Sec7 domain 1 [KO:K12495]
404781  
K12495 IQ motif and SEC7 domain-containing protein | (RefSeq) Iqsec3; IQ motif and Sec7 domain 3 [KO:K12495]
685244  
K12495 IQ motif and SEC7 domain-containing protein | (RefSeq) Iqsec2; IQ motif and Sec7 domain 2 [KO:K12495]
116691  
K18441 cytohesin | (RefSeq) Cyth1; cytohesin 1 [KO:K18441]
116692  
K18441 cytohesin | (RefSeq) Cyth2; cytohesin 2 [KO:K18441]
116693  
K18441 cytohesin | (RefSeq) Cyth3; cytohesin 3 [KO:K18441]
500906  
K18441 cytohesin | (RefSeq) Cyth4; cytohesin 4 [KO:K18441]
296380  
K18442 brefeldin A-inhibited guanine nucleotide-exchange protein | (RefSeq) Arfgef2; ADP ribosylation factor guanine nucleotide exchange factor 2 [KO:K18442]
312915  
K18442 brefeldin A-inhibited guanine nucleotide-exchange protein | (RefSeq) Arfgef1; ADP ribosylation factor guanine nucleotide exchange factor 1 [KO:K18442]
309451  
K18443 golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 | (RefSeq) Gbf1; golgi brefeldin A resistant guanine nucleotide exchange factor 1 [KO:K18443]
64310  
K07937 ADP-ribosylation factor 1 | (RefSeq) Arf1; ADP-ribosylation factor 1 [KO:K07937]
140940  
K07938 ADP-ribosylation factor 3 | (RefSeq) Arf3; ADP-ribosylation factor 3 [KO:K07938]
79117  
K07940 ADP-ribosylation factor 5 | (RefSeq) Arf5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  
GDP
C00044  
GTP
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C11556  
1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
Reference
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
Reference
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
Reference
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
Reference
(Japanese)
  Authors
Ohno H, Yoshimori T (eds).
  Title
[Current Stream in Membrane Traffic] (in Japanese)
  Journal
Tanpakushitsu Kakusan Koso 53 (2008)
Reference
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
Reference
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
Reference
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
Reference
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
Reference
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
Reference
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
KO pathway
 

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