KEGG   PATHWAY: rno04514Help
Entry
rno04514                    Pathway                                

Name
Cell adhesion molecules (CAMs) - Rattus norvegicus (rat)
Description
Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
Cell adhesion molecules (CAMs)
rno04514

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Organism
Rattus norvegicus (rat) [GN:rno]
Gene
497761  
Cd2; Cd2 molecule [KO:K06449]
25408  
Cd80; Cd80 molecule [KO:K05412]
499342  
Cd274; CD274 molecule [KO:K06745]
25660  
Cd28; Cd28 molecule [KO:K06470]
56822  
Cd86; CD86 molecule [KO:K05413]
63835  
Ctla4; cytotoxic T-lymphocyte-associated protein 4 [KO:K06538]
499415  
Icoslg; inducible T-cell co-stimulator ligand [KO:K06710]
64545  
Icos; inducible T-cell co-stimulator [KO:K06713]
294274  
RT1-DMa; RT1 class II, locus DMa [KO:K06752]
294273  
RT1-DMb; RT1 class II, locus DMb [KO:K06752]
24984  
RT1-DOa; RT1 class II, locus DOa [KO:K06752]
24986  
RT1-Ha; RT1 class II, locus Ha [KO:K06752]
294269  
RT1-Da; RT1 class II, locus Da [KO:K06752]
294270  
RT1-Db1; RT1 class II, locus Db1 [KO:K06752]
309621  
RT1-Ba; RT1 class II, locus Ba [KO:K06752]
309622  
RT1-Bb; RT1 class II, locus Bb [KO:K06752]
365542  
RT1-DOb; RT1 class II, locus DOb [KO:K06752]
688090  
Bb; similar to RT1 class II histocompatibility antigen, B-1 beta chain precursor (RT1.B-beta(1)) [KO:K06752]
class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
TRAV14S2; mCG140239-like [KO:K10784]
24932  
Cd4; Cd4 molecule [KO:K06454]
24737  
RT1-EC2; RT1 class Ib, locus EC2 [KO:K06751]
24747  
RT1-M3-1; RT1 class Ib, locus M3, gene 1 [KO:K06751]
24748  
RT1-N1; RT1 class Ib, locus N1 [KO:K06751]
24750  
RT1-N3; RT1 class Ib, locus N3 [KO:K06751]
24973  
RT1-A1; RT1 class Ia, locus A1 [KO:K06751]
24974  
RT1-A2; RT1 class Ia, locus A2 [KO:K06751]
24977  
RT1-Cl; RT1 class Ib, locus Cl [KO:K06751]
24988  
RT1-M2; RT1 class Ib, locus M2 [KO:K06751]
294213  
RT1-M1-4; RT1 class I, locus M1, gene 4 [KO:K06751]
309600  
RT1-CE12; RT1 class I, locus CE12 [KO:K06751]
309603  
RT1-CE1; RT1 class I, locus1 [KO:K06751]
309607  
RT1-CE5; RT1 class I, locus CE5 [KO:K06751]
309627  
RT1-A3; RT1 class I, locus A3 [KO:K06751]
361787  
RT1-T24-1; RT1 class I, locus T24, gene 1 [KO:K06751]
365527  
RT1-M6-2; RT1 class I, locus M6, gene 2 [KO:K06751]
368153  
RT1-CE7; RT1 class I, locus CE7 [KO:K06751]
414270  
RT1-CE14; RT1 class I, locus CE14 [KO:K06751]
414779  
RT1-CE2; RT1 class I, locus CE2 [KO:K06751]
414783  
RT1-CE4; RT1 class I, locus CE4 [KO:K06751]
414784  
RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  
RT1-M6-1; RT1 class I, locus M6, gene 1 [KO:K06751]
414786  
RT1-M1-2; RT1 class I, locus M1, gene 2 [KO:K06751]
414787  
RT1-M10-1; RT1 class I, locus M10, gene 1 [KO:K06751]
414789  
RT1-CE15; RT1 class I, locus CE15 [KO:K06751]
414790  
RT1-CE13; RT1 class I, locus CE13 [KO:K06751]
414791  
RT1-CE11; RT1 class I, locus CE11 [KO:K06751]
414792  
RT1-CE10; RT1 class I, locus CE10 [KO:K06751]
414793  
RT1-CE3; RT1 class I, locus CE3 [KO:K06751]
414819  
RT1-CE16; RT1 class I, locus CE16 [KO:K06751]
24751  
RT1-O1; RT1 class Ib, locus O1 [KO:K06751]
406194  
RT1-T18; RT1 class Ib, locus T18 [KO:K06751]
294228  
RT1-S3; RT1 class Ib, locus S3 [KO:K06751]
309584  
RT1-M4; RT1 class Ib, locus M4 [KO:K06751]
360323  
RT1-N2; RT1 class Ib, locus N2 [KO:K06751]
RT1-A; RT1 class I, locus A [KO:K06751]
414788  
RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751]
680842  
RT1-M1-5; RT1 class I, M1, gene 5 [KO:K06751]
HLA class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
499400  
RT1-M5; RT1 class Ib, locus M5 [KO:K06751]
24930  
Cd8a; CD8a molecule [KO:K06458]
24931  
Cd8b; CD8b molecule [KO:K06459]
309304  
Pdcd1lg2; programmed cell death 1 ligand 2 [KO:K06708]
315716  
Cd276; Cd276 molecule [KO:K06746]
295322  
Vtcn1; V-set domain containing T cell activation inhibitor 1 [KO:K06747]
301626  
Pdcd1; programmed cell death 1 [KO:K06744]
171369  
Cd40; CD40 molecule [KO:K03160]
84349  
Cd40lg; CD40 ligand [KO:K03161]
79559  
Alcam; activated leukocyte cell adhesion molecule [KO:K06547]
25752  
Cd6; Cd6 molecule [KO:K06456]
25066  
PVR; poliovirus receptor [KO:K06539]
307199  
Cd226; CD226 molecule [KO:K06567]
308417  
Nectin2; nectin cell adhesion molecule 2 [KO:K06531]
363784  
Tigit; T cell immunoreceptor with Ig and ITIM domains [KO:K16350]
308995  
Itgal; integrin subunit alpha L [KO:K05718]
309684  
Itgb2; integrin subunit beta 2 [KO:K06464]
25464  
Icam1; intercellular adhesion molecule 1 [KO:K06490]
360647  
Icam2; intercellular adhesion molecule 2 [KO:K06523]
308501  
Cd22; CD22 molecule [KO:K06467]
24699  
Ptprc; protein tyrosine phosphatase, receptor type, C [KO:K06478] [EC:3.1.3.48]
311426  
Siglec1; sialic acid binding Ig like lectin 1 [KO:K06548]
24796  
Spn; sialophorin [KO:K06477]
288521  
similar to Leukosialin precursor (Leucocyte sialoglycoprotein) (Sialophorin) (CD43) (W3/13 antigen); K06477 sialophorin [KO:K06477]
288124  
Nectin3; nectin cell adhesion molecule 3 [KO:K06592]
290485  
Cldn10; claudin 10 [KO:K06087]
290789  
Cldn23; claudin 23 [KO:K06087]
298487  
Cldn19; claudin 19 [KO:K06087]
300920  
Cldn2; claudin 2 [KO:K06087]
304073  
Cldn14; claudin 14 [KO:K06087]
304124  
Cldn8; claudin 8 [KO:K06087]
304125  
Cldn17; claudin 17 [KO:K06087]
304388  
Cldn15; claudin 15 [KO:K06087]
304407  
Cldn4; claudin 4 [KO:K06087]
306454  
Cldn22; claudin 22 [KO:K06087]
315953  
Cldn18; claudin 18 [KO:K06087]
65129  
Cldn1; claudin 1 [KO:K06087]
65130  
Cldn3; claudin 3 [KO:K06087]
65131  
Cldn5; claudin 5 [KO:K06087]
84588  
Cldn11; claudin 11 [KO:K06087]
155268  
Cldn16; claudin 16 [KO:K06087]
287098  
Cldn6; claudin 6 [KO:K06087]
287099  
Cldn9; claudin 9 [KO:K06087]
680178  
Cldn20; claudin 20 [KO:K06087]
65132  
Cldn7; claudin 7 [KO:K06087]
680370  
Cldn34d; claudin 34D [KO:K06087]
502083  
Cldn24; claudin 24 [KO:K06087]
claudin 25-like; K06087 claudin [KO:K06087]
83497  
Ocln; occludin [KO:K06088]
116479  
F11r; F11 receptor [KO:K06089]
619374  
Jam2; junctional adhesion molecule 2 [KO:K06735]
315509  
Jam3; junctional adhesion molecule 3 [KO:K06785]
300519  
Esam; endothelial cell adhesion molecule [KO:K06787]
307618  
Cdh5; cadherin 5 [KO:K06533]
29583  
Pecam1; platelet and endothelial cell adhesion molecule 1 [KO:K06471]
652929  
Cd99; CD99 molecule [KO:K06520]
25021  
Itgam; integrin subunit alpha M [KO:K06461]
363930  
Selplg; selectin P ligand [KO:K06544]
25651  
Selp; selectin P [KO:K06496]
311144  
Itga4; integrin subunit alpha 4 [KO:K06483]
24511  
Itgb1; integrin subunit beta 1 [KO:K05719]
685004  
Itga9; integrin subunit alpha 9 [KO:K06585]
25361  
Vcam1; vascular cell adhesion molecule 1 [KO:K06527]
25713  
Itgb7; integrin subunit beta 7 [KO:K06590]
54266  
Madcam1; mucosal vascular addressin cell adhesion molecule 1 [KO:K06779]
29259  
Sell; selectin L [KO:K06495]
25258  
Glycam1; glycosylation dependent cell adhesion molecule 1 [KO:K06815]
305081  
Cd34; CD34 molecule [KO:K06474]
29476  
Glg1; golgi glycoprotein 1 [KO:K06816]
25544  
Sele; selectin E [KO:K06494]
192183  
Nectin1; nectin cell adhesion molecule 1 [KO:K06081]
83501  
Cdh2; cadherin 2 [KO:K06736]
24586  
Ncam1; neural cell adhesion molecule 1 [KO:K06491]
288280  
Ncam2; neural cell adhesion molecule 2 [KO:K06491]
50687  
L1cam; L1 cell adhesion molecule [KO:K06550]
363058  
Cadm1; cell adhesion molecule 1 [KO:K06781]
59318  
Negr1; neuronal growth regulator 1 [KO:K06775]
295382  
Ntng1; netrin G1 [KO:K07522]
311236  
Lrrc4c; leucine rich repeat containing 4C [KO:K07523]
311836  
Ntng2; netrin G2 [KO:K16359]
641521  
Lrrc4; leucine rich repeat containing 4 [KO:K16351]
360406  
Ptprf; protein tyrosine phosphatase, receptor type, F [KO:K05695] [EC:3.1.3.48]
308571  
Lrrc4b; leucine rich repeat containing 4B [KO:K16360]
25216  
Sdc1; syndecan 1 [KO:K06257]
25615  
Sdc2; syndecan 2 [KO:K16336]
116673  
Sdc3; syndecan 3 [KO:K16337]
24771  
Sdc4; syndecan 4 [KO:K16338]
296456  
Itgav; integrin subunit alpha V [KO:K06487]
362800  
Itgb8; integrin subunit beta 8 [KO:K06591]
364786  
Itga8; integrin subunit alpha 8 [KO:K06584]
60391  
Nrxn1; neurexin 1 [KO:K07377]
116595  
Nrxn2; neurexin 2 [KO:K07377]
116508  
Nrxn3; neurexin 3 [KO:K07377]
116647  
Nlgn1; neuroligin 1 [KO:K07378]
117096  
Nlgn2; neuroligin 2 [KO:K07378]
171297  
Nlgn3; neuroligin 3 [KO:K07378]
360882  
Cadm3; cell adhesion molecule 3 [KO:K06780]
497815  
Nrcam; neuronal cell adhesion molecule [KO:K06756]
117258  
Cntn1; contactin 1 [KO:K06759]
29616  
Ptprm; protein tyrosine phosphatase, receptor type, M [KO:K05693] [EC:3.1.3.48]
25356  
Cntn2; contactin 2 [KO:K06760]
116690  
Nfasc; neurofascin [KO:K06757]
84008  
Cntnap1; contactin associated protein 1 [KO:K07379]
contactin-associated protein-like 2; K07380 contactin associated protein-like 2 [KO:K07380]
24564  
Mpz; myelin protein zero [KO:K06770]
360871  
Mpzl1; myelin protein zero-like 1 [KO:K06770]
29409  
Mag; myelin-associated glycoprotein [KO:K06771]
83502  
Cdh1; cadherin 1 [KO:K05689]
114122  
Vcan; versican [KO:K06793]
114517  
Itga6; integrin subunit alpha 6 [KO:K06485]
116777  
Cdh3; cadherin 3 [KO:K06796]
114588  
Cdh4; cadherin 4 [KO:K06797]
361432  
Cdh15; cadherin 15 [KO:K06809]
81735  
Neo1; neogenin 1 [KO:K06766]
Reference
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
Reference
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
Reference
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
Reference
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
Reference
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
Reference
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
Reference
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
Reference
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
Reference
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
Reference
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
Reference
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
Reference
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
Reference
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
Reference
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
Reference
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
Reference
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
Reference
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
Reference
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
Reference
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
Reference
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
Reference
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
Reference
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
Reference
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
KO pathway
 

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