KEGG PATHWAY: rno04720

PATHWAY: rno04720

Entry

rno04720 Pathway

Name

Long-term potentiation - Rattus norvegicus (rat)

Description

Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII) . Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP).

Class

Organismal Systems; Nervous system

Pathway map

rno04720

Long-term potentiation

Other DBs

BSID:

83477

GO:

0048169

Organism

Rattus norvegicus (rat) [GN:rno]

Gene

50592	Gria1; glutamate receptor, ionotropic, AMPA 1 [KO:K05197]
29627	Gria2; glutamate receptor, ionotropic, AMPA 2 [KO:K05198]
305509	Adcy1; adenylate cyclase 1 (brain) [KO:K08041] [EC:4.6.1.1]
29241	Adcy8; adenylate cyclase 8 (brain) [KO:K08048] [EC:4.6.1.1]
25636	Prkaca; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
293508	Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
501563	Prkx; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
58977	Ppp1r1a; protein phosphatase 1, regulatory (inhibitor) subunit 1A [KO:K08050]
24668	Ppp1ca; protein phosphatase 1, catalytic subunit, alpha isozyme [KO:K06269] [EC:3.1.3.16]
24669	Ppp1cc; protein phosphatase 1, catalytic subunit, gamma isozyme [KO:K06269] [EC:3.1.3.16]
25594	Ppp1cb; protein phosphatase 1, catalytic subunit, beta isozyme [KO:K06269] [EC:3.1.3.16]
116670	Ppp1r12a; protein phosphatase 1, regulatory subunit 12A [KO:K06270]
304813	Ppp1r12b; protein phosphatase 1, regulatory subunit 12B [KO:K12329]
25400	Camk2a; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
24246	Camk2d; calcium/calmodulin-dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
24245	Camk2b; calcium/calmodulin-dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
171140	Camk2g; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
59326	Rapgef3; Rap guanine nucleotide exchange factor (GEF) 3 [KO:K08014]
295347	Rap1a; RAP1A, member of RAS oncogene family [KO:K04353]
171337	Rap1b; RAP1B, member of RAS oncogene family [KO:K07836]
24674	Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
24675	Ppp3cb; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
171378	Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
29748	Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha [KO:K06268]
29749	Ppp3r2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
64152	Chp; calcium binding protein p22 [KO:K06268]
500462	RGD1564956; similar to calcium binding protein P22 [KO:K06268]
499969	RGD1565588; similar to calcium binding protein P22 [KO:K06268]
308965	Chp2; calcineurin-like EF hand protein 2 [KO:K06268]
24408	Grin1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 [KO:K05208]
24409	Grin2a; glutamate receptor, ionotropic, N-methyl D-aspartate 2A [KO:K05209]
24410	Grin2b; glutamate receptor, ionotropic, N-methyl D-aspartate 2B [KO:K05210]
24411	Grin2c; glutamate receptor, ionotropic, N-methyl D-aspartate 2C [KO:K05211]
24412	Grin2d; glutamate receptor, ionotropic, N-methyl D-aspartate 2D [KO:K05212]
24239	Cacna1c; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
50663	Calm2; calmodulin 2 [KO:K02183]
24242	Calm1; calmodulin 1 [KO:K02183]
24244	Calm3; calmodulin 3 [KO:K02183]
364774	Calml5; calmodulin-like 5 [KO:K02183]
307100	Calml3; calmodulin-like 3 [KO:K02183]
54244	Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
170915	Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
79255	Atf4; activating transcription factor 4 (tax-responsive enhancer element B67) [KO:K04374]
25050	Camk4; calcium/calmodulin-dependent protein kinase IV [KO:K05869] [EC:2.7.11.17]
293621	Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
24525	Kras; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
24605	Nras; neuroblastoma ras oncogene [KO:K07828]
64363	Araf; v-raf murine sarcoma 3611 viral oncogene homolog [KO:K08845] [EC:2.7.11.1]
114486	Braf; v-raf murine sarcoma viral oncogene homolog B1 [KO:K04365] [EC:2.7.11.1]
24703	Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
170851	Map2k1; mitogen activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
58960	Map2k2; mitogen activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116590	Mapk1; mitogen activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
50689	Mapk3; mitogen activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
81771	Rps6ka1; ribosomal protein S6 kinase polypeptide 1 [KO:K04373] [EC:2.7.11.1]
117269	Rps6ka2; ribosomal protein S6 kinase polypeptide 2 [KO:K04373] [EC:2.7.11.1]
501560	Rps6ka3; ribosomal protein S6 kinase polypeptide 3 [KO:K04373] [EC:2.7.11.1]
317203	Rps6ka6; ribosomal protein S6 kinase polypeptide 6 [KO:K04373] [EC:2.7.11.1]
25262	Itpr1; inositol 1,4,5-trisphosphate receptor, type 1 [KO:K04958]
81678	Itpr2; inositol 1,4,5-trisphosphate receptor, type 2 [KO:K04959]
25679	Itpr3; inositol 1,4,5-trisphosphate receptor, type 3 [KO:K04960]
24680	Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
24681	Prkcg; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
25023	Prkcb; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
24414	Grm1; glutamate receptor, metabotropic 1 [KO:K04603]
24418	Grm5; glutamate receptor, metabotropic 5 [KO:K04604]
81666	Gnaq; guanine nucleotide binding protein (G protein), q polypeptide [KO:K04634]
24654	Plcb1; phospholipase C, beta 1 (phosphoinositide-specific) [KO:K05858] [EC:3.1.4.11]
29322	Plcb3; phospholipase C, beta 3 (phosphatidylinositol-specific) [KO:K05858] [EC:3.1.4.11]
85240	Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
25031	Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]

Compound

C00025	L-Glutamate
C00076	Calcium cation
C00165	Diacylglycerol
C00305	Magnesium cation
C00575	3',5'-Cyclic AMP
C01245	D-myo-Inositol 1,4,5-trisphosphate
C01330	Sodium cation

Reference

PMID:15652868

Authors

Blitzer RD, Iyengar R, Landau EM.

Title

Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity.

Journal

Biol Psychiatry 57:113-9 (2005)

Reference

PMID:10652548

Authors

Soderling TR, Derkach VA.

Title

Postsynaptic protein phosphorylation and LTP.

Journal

Trends Neurosci 23:75-80 (2000)

Reference

PMID:11378299

Authors

Poser S, Storm DR.

Title

Role of Ca2+-stimulated adenylyl cyclases in LTP and memory formation.

Journal

Int J Dev Neurosci 19:387-94 (2001)

Reference

PMID:15803158

Authors

Xia Z, Storm DR.

Title

The role of calmodulin as a signal integrator for synaptic plasticity.

Journal

Nat Rev Neurosci 6:267-76 (2005)

Reference

Authors

Purves D, Augustine GJ (ed).

Title

Neuroscience

Journal

Sunderland, Mass.:Sinauer Associates (2004)

Reference

(Japanese)

Authors

Futai K, Hayashi Y.

Title

[Molecular mechanisms of hippocampal long-term potentiation.] (In Japanese)

Journal

Experimental Medicine 21(17):2361-2369 (2003)

Reference

PMID:14715912

Authors

Lynch MA.

Title

Long-term potentiation and memory.

Journal

Physiol Rev 84:87-136 (2004)

Reference

PMID:15857686

Authors

Kelly PT, Mackinnon RL 2nd, Dietz RV, Maher BJ, Wang J.

Title

Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neurons.

Journal

Brain Res Mol Brain Res 135:232-48 (2005)

Reference

PMID:9697848

Authors

Berridge MJ.

Title

Neuronal calcium signaling.

Journal

Neuron 21:13-26 (1998)

KO pathway

ko04720

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (71)   
   KEGG GENES (71)   
All databases (73)   

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