Salmonella infection - Rattus norvegicus (rat)

Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.

Human Diseases; Infectious diseases

Rattus norvegicus (rat) [GN:rno]

PMID:20526845

Trebichavsky I, Splichal I, Splichalova A

Innate immune response in the gut against Salmonella - review.

Folia Microbiol (Praha) 55:295-300 (2010)

PMID:19930040

Talbot S, Totemeyer S, Yamamoto M, Akira S, Hughes K, Gray D, Barr T, Mastroeni P, Maskell DJ, Bryant CE

Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella  enterica serovar typhimurium infection, but not for the initiation of bacterial clearance.

Immunology 128:472-83 (2009)

PMID:19775254

Ibarra JA, Steele-Mortimer O

Salmonella--the ultimate insider. Salmonella virulence factors that modulate intracellular survival.

Cell Microbiol 11:1579-86 (2009)

PMID:11489966

Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL

Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression.

J Immunol 167:1882-5 (2001)

PMID:17071592

Vijay-Kumar M, Wu H, Jones R, Grant G, Babbin B, King TP, Kelly D, Gewirtz AT, Neish AS

Flagellin suppresses epithelial apoptosis and limits disease during enteric infection.

Am J Pathol 169:1686-700 (2006)

PMID:17690885

Miao EA, Andersen-Nissen E, Warren SE, Aderem A

TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system.

Semin Immunopathol 29:275-88 (2007)

PMID:20158475

Bueno SM, Riedel CA, Carreno LJ, Kalergis AM

Virulence mechanisms displayed by Salmonella to impair dendritic cell function.

Curr Med Chem 17:1156-66 (2010)

PMID:18026123

Haraga A, Ohlson MB, Miller SI

Salmonellae interplay with host cells.

Nat Rev Microbiol 6:53-66 (2008)

PMID:11825778

Kimbrough TG, Miller SI

Assembly of the type III secretion needle complex of Salmonella typhimurium.

Microbes Infect 4:75-82 (2002)

PMID:17074883

Patel JC, Galan JE

Differential activation and function of Rho GTPases during Salmonella-host cell interactions.

J Cell Biol 175:453-63 (2006)

PMID:20123714

Bulgin R, Raymond B, Garnett JA, Frankel G, Crepin VF, Berger CN, Arbeloa A

Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors.

Infect Immun 78:1417-25 (2010)

PMID:18778407

Bakowski MA, Braun V, Brumell JH

Salmonella-containing vacuoles: directing traffic and nesting to grow.

Traffic 9:2022-31 (2008)

PMID:18411289

Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH

Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.

Infect Immun 76:2722-35 (2008)

PMID:11567004

Nikolaus T, Deiwick J, Rappl C, Freeman JA, Schroder W, Miller SI, Hensel M

SseBCD proteins are secreted by the type III secretion system of Salmonella pathogenicity island 2 and function as a translocon.

J Bacteriol 183:6036-45 (2001)

PMID:11755407

Eckmann L, Kagnoff MF

Cytokines in host defense against Salmonella.

Microbes Infect 3:1191-200 (2001)

PMID:10499590

Fu Y, Galan JE

A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.

Nature 401:293-7 (1999)

PMID:19779561

Du F, Galan JE

Selective inhibition of type III secretion activated signaling by the Salmonella  effector AvrA.

PLoS Pathog 5:e1000595 (2009)

PMID:18407067

Jones RM, Wu H, Wentworth C, Luo L, Collier-Hyams L, Neish AS

Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade.

Cell Host Microbe 3:233-44 (2008)

PMID:16611232

Haraga A, Miller SI

A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1.

Cell Microbiol 8:837-46 (2006)

PMID:16800847

Abrahams GL, Muller P, Hensel M

Functional dissection of SseF, a type III effector protein involved in positioning the salmonella-containing vacuole.

Traffic 7:950-65 (2006)

PMID:16938850

Henry T, Couillault C, Rockenfeller P, Boucrot E, Dumont A, Schroeder N, Hermant A, Knodler LA, Lecine P, Steele-Mortimer O, Borg JP, Gorvel JP, Meresse S

The Salmonella effector protein PipB2 is a linker for kinesin-1.

Proc Natl Acad Sci U S A 103:13497-502 (2006)

PMID:12675800

Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI

Salmonella effectors translocated across the vacuolar membrane interact with the  actin cytoskeleton.

Mol Microbiol 48:401-15 (2003)

PMID:20943123

Prior K, Hautefort I, Hinton JC, Richardson DJ, Rowley G

All stressed out. Salmonella pathogenesis and reactive nitrogen species.

Adv Microb Physiol 56:1-28 (2009)