Legionellosis - Rattus norvegicus (rat)

Legionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated with Legionella species: Legionnaires' disease is the more severe form of the infection, which may involve pneumonia, and Pontiac fever is a milder respiratory illness.
The pathogenesis of L. pneumophila is derived from its growth within lung macrophages. One of the L. pneumophila's type IV secretion systems, the Dot/Icm secretion system, is of critical importance for its ability to replicate and to cause disease. The Dot/Icm substrates modulate multiple host cell processes and in particular, redirect trafficking of the L. pneumophila phagosome and mediate its conversion into an ER-derived organelle competent for intracellular bacterial replication. L. pneumophila also manipulates host cell death and survival pathways in a way that allows continued intracellular replication.

Human Diseases; Infectious diseases

Rattus norvegicus (rat) [GN:rno]

PMID:20375353

Newton HJ, Ang DK, van Driel IR, Hartland EL

Molecular pathogenesis of infections caused by Legionella pneumophila.

Clin Microbiol Rev 23:274-98 (2010)

PMID:18363881

Shin S, Roy CR

Host cell processes that influence the intracellular survival of Legionella pneumophila.

Cell Microbiol 10:1209-20 (2008)

PMID:19157961

Ensminger AW, Isberg RR

Legionella pneumophila Dot/Icm translocated substrates: a sum of parts.

Curr Opin Microbiol 12:67-73 (2009)

PMID:15972519

Chang B, Kura F, Amemura-Maekawa J, Koizumi N, Watanabe H

Identification of a novel adhesion molecule involved in the virulence of Legionella pneumophila.

Infect Immun 73:4272-80 (2005)

PMID:18549456

Liu M, Conover GM, Isberg RR

Legionella pneumophila EnhC is required for efficient replication in tumour necrosis factor alpha-stimulated macrophages.

Cell Microbiol 10:1906-23 (2008)

PMID:19021631

Weber SS, Ragaz C, Hilbi H

The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of  Legionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE.

Cell Microbiol 11:442-60 (2009)

PMID:16495539

Newton HJ, Sansom FM, Bennett-Wood V, Hartland EL

Identification of Legionella pneumophila-specific genes by genomic subtractive hybridization with Legionella micdadei and identification of lpnE, a gene required for efficient host cell entry.

Infect Immun 74:1683-91 (2006)

PMID:18048909

De Buck E, Anne J, Lammertyn E

The role of protein secretion systems in the virulence of the intracellular pathogen Legionella pneumophila.

Microbiology 153:3948-53 (2007)

PMID:19687203

Chong A, Lima CA, Allan DS, Nasrallah GK, Garduno RA

The purified and recombinant Legionella pneumophila chaperonin alters mitochondrial trafficking and microfilament organization.

Infect Immun 77:4724-39 (2009)

PMID:1721820

Cooper NR

Complement evasion strategies of microorganisms.

Immunol Today 12:327-31 (1991)

PMID:16824952

Machner MP, Isberg RR

Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila.

Dev Cell 11:47-56 (2006)

PMID:12427954

Neumeister B, Faigle M, Lauber K, Northoff H, Wesselborg S

Legionella pneumophila induces apoptosis via the mitochondrial death pathway.

Microbiology 148:3639-50 (2002)

PMID:17124169

Laguna RK, Creasey EA, Li Z, Valtz N, Isberg RR

A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death.

Proc Natl Acad Sci U S A 103:18745-50 (2006)

PMID:19666608

Ge J, Xu H, Li T, Zhou Y, Zhang Z, Li S, Liu L, Shao F

A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating  the IkappaB family of inhibitors.

Proc Natl Acad Sci U S A 106:13725-30 (2009)

PMID:18284575

Kubori T, Hyakutake A, Nagai H

Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions.

Mol Microbiol 67:1307-19 (2008)

PMID:19386084

Shen X, Banga S, Liu Y, Xu L, Gao P, Shamovsky I, Nudler E, Luo ZQ

Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response.

Cell Microbiol 11:911-26 (2009)

PMID:19478083

Belyi Y, Stahl M, Sovkova I, Kaden P, Luy B, Aktories K

Region of elongation factor 1A1 involved in substrate recognition by Legionella pneumophila glucosyltransferase Lgt1: identification of Lgt1 as a retaining glucosyltransferase.

J Biol Chem 284:20167-74 (2009)

PMID:18281405

Belyi Y, Tabakova I, Stahl M, Aktories K

Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophila.

J Bacteriol 190:3026-35 (2008)

PMID:19343209

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CB, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO

Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.

PLoS Pathog 5:e1000361 (2009)

PMID:20941588

Palusinska-Szysz M, Janczarek M

Innate immunity to Legionella and toll-like receptors - review.

Folia Microbiol (Praha) 55:508-14 (2010)