KEGG   PATHWAY: rno05330Help
Entry
rno05330                    Pathway                                

Name
Allograft rejection - Rattus norvegicus (rat)
Description
Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.
Class
Human Diseases; Immune diseases
BRITE hierarchy
Pathway map
Allograft rejection
rno05330

All organismsOrtholog table
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
24737  
RT1-EC2; RT1 class Ib, locus EC2 [KO:K06751]
24747  
RT1-M3-1; RT1 class Ib, locus M3, gene 1 [KO:K06751]
24748  
RT1-N1; RT1 class Ib, locus N1 [KO:K06751]
24750  
RT1-N3; RT1 class Ib, locus N3 [KO:K06751]
24973  
RT1-A1; RT1 class Ia, locus A1 [KO:K06751]
24974  
RT1-A2; RT1 class Ia, locus A2 [KO:K06751]
24977  
RT1-Cl; RT1 class Ib, locus Cl [KO:K06751]
24988  
RT1-M2; RT1 class Ib, locus M2 [KO:K06751]
294213  
RT1-M1-4; RT1 class I, locus M1, gene 4 [KO:K06751]
309600  
RT1-CE12; RT1 class I, locus CE12 [KO:K06751]
309603  
RT1-CE1; RT1 class I, locus1 [KO:K06751]
309607  
RT1-CE5; RT1 class I, locus CE5 [KO:K06751]
309627  
RT1-A3; RT1 class I, locus A3 [KO:K06751]
361787  
RT1-T24-1; RT1 class I, locus T24, gene 1 [KO:K06751]
365527  
RT1-M6-2; RT1 class I, locus M6, gene 2 [KO:K06751]
368153  
RT1-CE7; RT1 class I, locus CE7 [KO:K06751]
414270  
RT1-CE14; RT1 class I, locus CE14 [KO:K06751]
414779  
RT1-CE2; RT1 class I, locus CE2 [KO:K06751]
414783  
RT1-CE4; RT1 class I, locus CE4 [KO:K06751]
414784  
RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  
RT1-M6-1; RT1 class I, locus M6, gene 1 [KO:K06751]
414786  
RT1-M1-2; RT1 class I, locus M1, gene 2 [KO:K06751]
414787  
RT1-M10-1; RT1 class I, locus M10, gene 1 [KO:K06751]
414789  
RT1-CE15; RT1 class I, locus CE15 [KO:K06751]
414790  
RT1-CE13; RT1 class I, locus CE13 [KO:K06751]
414791  
RT1-CE11; RT1 class I, locus CE11 [KO:K06751]
414792  
RT1-CE10; RT1 class I, locus CE10 [KO:K06751]
414793  
RT1-CE3; RT1 class I, locus CE3 [KO:K06751]
414819  
RT1-CE16; RT1 class I, locus CE16 [KO:K06751]
24751  
RT1-O1; RT1 class Ib, locus O1 [KO:K06751]
406194  
RT1-T18; RT1 class Ib, locus T18 [KO:K06751]
294228  
RT1-S3; RT1 class Ib, locus S3 [KO:K06751]
309584  
RT1-M4; RT1 class Ib, locus M4 [KO:K06751]
360323  
RT1-N2; RT1 class Ib, locus N2 [KO:K06751]
Rt1.aa; MHC class I RT1.Aa alpha-chain [KO:K06751]
414788  
RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751]
680842  
RT1-M1-5; RT1 class I, M1, gene 5 [KO:K06751]
25408  
Cd80; Cd80 molecule [KO:K05412]
56822  
Cd86; CD86 molecule [KO:K05413]
25660  
Cd28; Cd28 molecule [KO:K06470]
84405  
Il12a; interleukin 12A [KO:K05406]
64546  
Il12b; interleukin 12B [KO:K05425]
25385  
Faslg; Fas ligand (TNF superfamily, member 6) [KO:K04389]
246097  
Fas; Fas cell surface death receptor [KO:K04390]
50669  
Prf1; perforin 1 (pore forming protein) [KO:K07818]
171528  
Gzmb; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) [KO:K01353] [EC:3.4.21.79]
Gzmbl2; Granzyme B-like 2 [KO:K01353] [EC:3.4.21.79]
294274  
RT1-DMa; RT1 class II, locus DMa [KO:K06752]
294273  
RT1-DMb; RT1 class II, locus DMb [KO:K06752]
24984  
RT1-DOa; RT1 class II, locus DOa [KO:K06752]
24986  
RT1-Ha; RT1 class II, locus Ha [KO:K06752]
294269  
RT1-Da; RT1 class II, locus Da [KO:K06752]
294270  
RT1-Db1; RT1 class II, locus Db1 [KO:K06752]
309621  
RT1-Ba; RT1 class II, locus Ba [KO:K06752]
309622  
RT1-Bb; RT1 class II, locus Bb [KO:K06752]
365542  
RT1-DOb; RT1 class II, locus DOb [KO:K06752]
688090  
Bb; similar to RT1 class II histocompatibility antigen, B-1 beta chain precursor (RT1.B-beta(1)) [KO:K06752]
class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
116562  
Il2; interleukin 2 [KO:K05429]
84349  
Cd40lg; CD40 ligand [KO:K03161]
171369  
Cd40; CD40 molecule, TNF receptor superfamily member 5 [KO:K03160]
25712  
Ifng; interferon gamma [KO:K04687]
24835  
Tnf; tumor necrosis factor [KO:K03156]
287287  
Il4; interleukin 4 [KO:K05430]
24497  
Il5; interleukin 5 [KO:K05428]
25325  
Il10; interleukin 10 [KO:K05443]
Compound
C00533  
Nitric oxide
Reference
  Authors
Arakelov A, Lakkis FG.
  Title
The alloimmune response and effector mechanisms of allograft rejection.
  Journal
Semin Nephrol 20:95-102 (2000)
Reference
  Authors
Le Moine A, Goldman M, Abramowicz D.
  Title
Multiple pathways to allograft rejection.
  Journal
Transplantation 73:1373-81 (2002)
Reference
  Authors
Trivedi HL.
  Title
Immunobiology of rejection and adaptation.
  Journal
Transplant Proc 39:647-52 (2007)
Reference
  Authors
Pietra BA.
  Title
Transplantation immunology 2003: simplified approach.
  Journal
Pediatr Clin North Am 50:1233-59 (2003)
Reference
PMID:8835634
  Authors
Oka T, Yoshimura N.
  Title
Immunosuppression in organ transplantation.
  Journal
Jpn J Pharmacol 71:89-100 (1996)
Reference
  Authors
Sayegh MH.
  Title
Why do we reject a graft? Role of indirect allorecognition in graft rejection.
  Journal
Kidney Int 56:1967-79 (1999)
Reference
  Authors
Benichou G.
  Title
Direct and indirect antigen recognition: the pathways to allograft immune rejection.
  Journal
Front Biosci 4:D476-80 (1999)
Reference
  Authors
Turvey SE, Wood KJ.
  Title
Immunobiology of solid organ transplantation.
  Journal
Int Surg 84:279-90 (1999)
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
  Authors
Game DS, Lechler RI.
  Title
Pathways of allorecognition: implications for transplantation tolerance.
  Journal
Transpl Immunol 10:101-8 (2002)
Reference
  Authors
Lechler RI, Garden OA, Turka LA.
  Title
The complementary roles of deletion and regulation in transplantation tolerance.
  Journal
Nat Rev Immunol 3:147-58 (2003)
KO pathway
 

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