KEGG   PATHWAY: rpw03440
Entry
rpw03440                    Pathway                                
Name
Homologous recombination - Rickettsia prowazekii Chernikova
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
rpw03440  Homologous recombination
rpw03440

Other DBs
GO: 0000724
Organism
Rickettsia prowazekii Chernikova [GN:rpw]
Gene
M9W_02530  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
M9W_04055  single-stranded DNA-binding protein [KO:K03111]
M9W_00130  recF; recombination protein F [KO:K03629]
M9W_02635  recO; DNA repair protein RecO [KO:K03584]
M9W_02130  recR; recombination protein RecR [KO:K06187]
M9W_03690  recA; recombinase A [KO:K03553]
M9W_01870  ruvA; Holliday junction DNA helicase RuvA [KO:K03550]
M9W_01875  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
M9W_00570  ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.21.10]
M9W_02845  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
M9W_03770  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
M9W_02035  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
M9W_04195  DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
M9W_00925  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
M9W_00830  DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
M9W_03545  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
M9W_04230  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
M9W_02595  primosome assembly protein PriA [KO:K04066] [EC:5.6.2.4]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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