KEGG PATHWAY: rsp02030

PATHWAY: rsp02030

Entry

rsp02030 Pathway

Name

Bacterial chemotaxis - Rhodobacter sphaeroides 2.4.1

Description

Chemotaxis is the process by which cells sense chemical gradients in their environment and then move towards more favorable conditions. In chemotaxis, events at the receptors control autophosphorylation of the CheA histidine kinase, and the phosphohistidine is the substrate for the response regulator CheY, which catalyzes the transfer of the phosphoryl group to a conserved aspartate. The resulting CheY-P can interact with the switch mechanism in the motor. This interaction causes a change in behavior, such as in direction or speed of rotation of flagella.

Class

Cellular Processes; Cell motility

Pathway map

rsp02030

Bacterial chemotaxis

Module

rsp_M00506

CheA-CheYBV (chemotaxis) two-component regulatory system [PATH:rsp02030]

Other DBs

BSID:

27555

GO:

0006935

Organism

Rhodobacter sphaeroides 2.4.1 [GN:rsp]

Gene

RSP_3420	methyl-accepting chemotaxis protein; K03406 methyl-accepting chemotaxis protein [KO:K03406]
RSP_3432	methyl-accepting chemotaxis protein; K03406 methyl-accepting chemotaxis protein [KO:K03406]
RSP_2440	mcpA; methyl accepting chemotaxis protein [KO:K03406]
RSP_2442	mcpB; methyl accepting chemotaxis protein, McpB [KO:K03406]
RSP_0044	tlpT; cytoplasmic chemoreceptor, TlpT [KO:K03406]
RSP_1589	tlpC; transducer-like protein, TlpC [KO:K03406]
RSP_3083	mcpH; methyl accepting chemotaxis protein [KO:K03406]
RSP_3108	methyl accepting chemotaxis protein; K03406 methyl-accepting chemotaxis protein [KO:K03406]
RSP_3303	mcpG; methyl accepting chemotaxis protein, McpG [KO:K03406]
RSP_0218	mcpM; methyl accepting chemotaxis protein [KO:K03406]
RSP_3708	mcpJ; methyl accepting chemotaxis protein [KO:K03406]
RSP_1249	ribose ABC transporter; K10439 ribose transport system substrate-binding protein [KO:K10439]
RSP_3231	peptide ABC transporter substrate-binding protein; K12368 dipeptide transport system substrate-binding protein [KO:K12368]
RSP_2436	cheA1; chemotaxis histidine protein kinase, CheA1 [KO:K03407] [EC:2.7.13.3]
RSP_0042	cheA3; chemotaxis histidine protein kinase, CheA3 [KO:K03407] [EC:2.7.13.3]
RSP_0049	cheA4; chemotaxis histidine protein kinase, CheA4 [KO:K03407] [EC:2.7.13.3]
RSP_1584	cheA2; chemotaxis histidine protein kinase [KO:K03407] [EC:2.7.13.3]
RSP_2435	cheW1; chemotaxis scaffold protein, CheW1 [KO:K03408]
RSP_0046	cheW4; chemotaxis protein CheW [KO:K03408]
RSP_1585	cheW2; chemotaxis protein, CheW2 [KO:K03408]
RSP_1586	cheW3; chemotaxis protein, CheW3 [KO:K03408]
RSP_1583	cheY3; chemotaxis response regulator, CheY3 [KO:K03413]
RSP_2433	cheY2; chemotaxis response regulator, CheY2 [KO:K03413]
RSP_3302	cheY4; chemotaxis response regulator, CheY4 [KO:K03413]
RSP_2437	cheY1; chemotaxis response regulator, CheY1 [KO:K03413]
RSP_2443	cheY5; chemotaxis response regulator, CheY5 [KO:K03413]
RSP_0043	cheY6; chemotaxis response regulator, CheY6 [KO:K03413]
RSP_2438	cheX; CheX protein [KO:K03409]
RSP_0047	cheB2; chemotaxis methylesterase, CheB2 [KO:K03412] [EC:3.1.1.61]
RSP_1588	cheB1; chemotaxis methylesterase, CheB1 [KO:K03412] [EC:3.1.1.61]
RSP_2229	methylesterase CheB/methylase CheR; K13924 two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61] [KO:K13924] [EC:3.1.1.61 2.1.1.80]
RSP_2439	cheD; chemoreceptor glutamine deamidase CheD [KO:K03411] [EC:3.5.1.44]
RSP_2434	cheR1; MCP methyltransferase, CheR1 [KO:K00575] [EC:2.1.1.80]
RSP_0048	cheR3; chemotaxis protein CheR [KO:K00575] [EC:2.1.1.80]
RSP_1587	cheR2; chemotaxis methyltransferase, CheR2 [KO:K00575] [EC:2.1.1.80]
RSP_0054	fliG; flagellar motor switch protein FliG [KO:K02410]
RSP_2220	flagellar motor switch protein (fliG); K02410 flagellar motor switch protein FliG [KO:K02410]
RSP_6099	flagellar switch protein FliM; K02416 flagellar motor switch protein FliM [KO:K02416]
RSP_0060	fliM; flagellar switch protein FliM [KO:K02416]
RSP_0061	fliN; flagellar motor switch FliN protein [KO:K02417]
RSP_1310	hypothetical protein; K02417 flagellar motor switch protein FliN/FliY [KO:K02417]
RSP_0233	motA; flagellar motor protein MotA [KO:K02556]
RSP_1316	motA; flagellar motor protein MotA [KO:K02556]
RSP_0231	motB; flagellar MotB protein [KO:K02557]
RSP_1302	motB; chemotaxis MotB protein [KO:K02557]
RSP_2289	hypothetical protein; K02557 chemotaxis protein MotB [KO:K02557]

Compound

C00049	L-Aspartate
C00107	Dipeptide
C00121	D-Ribose
C00124	D-Galactose
C00208	Maltose
C00716	DL-Serine

Reference

PMID:12011078

Authors

Kristich CJ, Ordal GW.

Title

Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis.

Journal

J Biol Chem 277:25356-62 (2002)

Reference

PMID:11722727

Authors

Kirby JR, Kristich CJ, Saulmon MM, Zimmer MA, Garrity LF, Zhulin IB, Ordal GW.

Title

CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis.

Journal

Mol Microbiol 42:573-85 (2001)

Reference

PMID:12920116

Authors

Szurmant H, Bunn MW, Cannistraro VJ, Ordal GW.

Title

Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch.

Journal

J Biol Chem 278:48611-6 (2003)

Reference

PMID:14749334

Authors

Szurmant H, Muff TJ, Ordal GW.

Title

Bacillus subtilis CheC and FliY are members of a novel class of CheY-P-hydrolyzing proteins in the chemotactic signal transduction cascade.

Journal

J Biol Chem 279:21787-92 (2004)

Reference

PMID:11158445

Authors

Yoshihara S, Geng X, Okamoto S, Yura K, Murata T, Go M, Ohmori M, Ikeuchi M.

Title

Mutational analysis of genes involved in pilus structure, motility and transformation competency in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803.

Journal

Plant Cell Physiol 42:63-73 (2001)

Reference

PMID:8104179

Authors

Darzins A.

Title

The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY.

Journal

J Bacteriol 175:5934-44 (1993)

Reference

PMID:15187186

Authors

Szurmant H, Ordal GW

Title

Diversity in chemotaxis mechanisms among the bacteria and archaea.

Journal

Microbiol Mol Biol Rev 68:301-19 (2004)

Reference

PMID:18774298

Authors

Rao CV, Glekas GD, Ordal GW

Title

The three adaptation systems of Bacillus subtilis chemotaxis.

Journal

Trends Microbiol 16:480-7 (2008)

Reference

PMID:18990184

Authors

Muff TJ, Ordal GW

Title

The diverse CheC-type phosphatases: chemotaxis and beyond.

Journal

Mol Microbiol 70:1054-61 (2008)

Reference

PMID:19203648

Authors

Miller LD, Russell MH, Alexandre G

Title

Diversity in bacterial chemotactic responses and niche adaptation.

Journal

Adv Appl Microbiol 66:53-75 (2009)

KO pathway

ko02030

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (46)   
   KEGG GENES (46)   
All databases (48)   

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