KEGG   PATHWAY: say03440Help
Entry
say03440                    Pathway                                

Name
Homologous recombination - Sulfobacillus acidophilus TPY
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
say03440  Homologous recombination
say03440

Ortholog table
Module
say_M00260  DNA polymerase III complex, bacteria [PATH:say03440]
Other DBs
BSID: 377124
GO: 0000724
Organism
Sulfobacillus acidophilus TPY [GN:say]
Gene
TPY_3374  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
TPY_3813  ssb; single-strand binding protein [KO:K03111]
TPY_0003  recF; DNA replication and repair protein RecF [KO:K03629]
TPY_0720  recO; DNA repair protein RecO [KO:K03584]
TPY_0130  recR; DNA replication and repair protein RecR [KO:K06187]
TPY_1656  recA; recA protein [KO:K03553]
TPY_1056  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
TPY_3509  ruvA; Holliday junction DNA helicase motor protein [KO:K03550] [EC:3.6.4.12]
TPY_3508  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
TPY_3510  ruvC; crossover junction endodeoxyribonuclease ruvC [KO:K01159] [EC:3.1.22.4]
TPY_1147  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
TPY_3428  dnaE; DNA-directed DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
TPY_1706  polC; DNA polymerase III PolC [KO:K03763] [EC:2.7.7.7]
TPY_2672  dnaN; DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
TPY_0002  dnaN; DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
TPY_0128  dnaX; DNA polymerase III gamma and tau subunits [KO:K02343] [EC:2.7.7.7]
TPY_0686  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
TPY_0175  holB; DNA-directed DNA polymerase [KO:K02341] [EC:2.7.7.7]
TPY_1136  priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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