KEGG   PATHWAY: sce04011Help
Entry
sce04011                    Pathway                                
Name
MAPK signaling pathway - yeast - Saccharomyces cerevisiae (budding yeast)
Description
The S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third (Hog1) is necessary for survival under hyperosmotic conditions. A fourth (Slt2/Mpk1) is required for repair of injuries to the cell wall. As in mammalian cells, these pathways consist of a conserved module in which three kinases phosphorylate each other in sequence. The MAPK is phosphorylated by the MAPK/ERK kinase (MEK), which is itself phosphorylated by a MEK kinase (MEKK).
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
MAPK signaling pathway - yeast
sce04011

All organismsOrtholog table
Module
SLN1-YPD1-SSK1/SKN7 (osmosensing) two-component regulatory system [PATH:sce04011]
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
MF(ALPHA)2; Mf(alpha)2p [KO:K11234]
MF(ALPHA)1; Mf(alpha)1p [KO:K11234]
MFA1; Mfa1p [KO:K11235]
MFA2; Mfa2p [KO:K11235]
STE2; Ste2p [KO:K11213]
STE3; Ste3p [KO:K04627]
STE18; Ste18p [KO:K07973]
CDC42; Cdc42p [KO:K04393]
CDC24; Cdc24p [KO:K11236]
BEM1; Bem1p [KO:K11237]
BNI1; Bni1p [KO:K11238]
STE20; Ste20p [KO:K04409] [EC:2.7.11.1]
STE11; Ste11p [KO:K11228] [EC:2.7.11.1]
STE5; Ste5p [KO:K11239]
STE7; Ste7p [KO:K11226] [EC:2.7.12.2]
MSG5; Msg5p [KO:K11240] [EC:3.1.3.48]
DIG1; Dig1p [KO:K11241]
DIG2; Dig2p [KO:K11242]
STE12; Ste12p [KO:K11215]
FUS1; Fus1p [KO:K11243]
FAR1; Far1p [KO:K06652]
WSC2; Wsc2p [KO:K11244]
SLG1; Slg1p [KO:K11244]
WSC3; Wsc3p [KO:K11244]
MID2; Mid2p [KO:K11245]
PKC1; Pkc1p [KO:K02677] [EC:2.7.11.13]
BCK1; Bck1p [KO:K11229] [EC:2.7.11.1]
MKK1; Mkk1p [KO:K08294] [EC:2.7.12.2]
MKK2; Mkk2p [KO:K08294] [EC:2.7.12.2]
SLT2; Slt2p [KO:K04464] [EC:2.7.11.24]
MLP1; Mlp1p [KO:K09291]
MLP2; Mlp2p [KO:K09291]
SWI4; Swi4p [KO:K06649]
SWI6; Swi6p [KO:K06648]
SHO1; Sho1p [KO:K11246]
SLN1; Sln1p [KO:K11231] [EC:2.7.13.3]
YPD1; Ypd1p [KO:K11232]
SSK1; Ssk1p [KO:K11233]
SSK22; Ssk22p [KO:K11230] [EC:2.7.11.25]
SSK2; Ssk2p [KO:K11230] [EC:2.7.11.25]
PBS2; Pbs2p [KO:K11227] [EC:2.7.12.2]
HOG1; Hog1p [KO:K04441] [EC:2.7.11.24]
MSN4; Msn4p [KO:K09468]
MSN2; Msn2p [KO:K09468]
GLO1; lactoylglutathione lyase GLO1 [KO:K01759] [EC:4.4.1.5]
TEC1; Tec1p [KO:K09448]
FUS3; Fus3p [KO:K04371] [EC:2.7.11.24]
GSC2; Gsc2p [KO:K00706] [EC:2.4.1.34]
KSS1; Kss1p [KO:K04371] [EC:2.7.11.24]
CTT1; catalase T [KO:K03781] [EC:1.11.1.6]
GPA1; Gpa1p [KO:K04640]
FKS1; Fks1p [KO:K00706] [EC:2.4.1.34]
MCM1; Mcm1p [KO:K12412]
RAS2; Ras2p [KO:K07974]
RLM1; Rlm1p [KO:K09265]
RHO1; Rho1p [KO:K07975]
KO pathway
 
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