| Entry |
|
|---|
| Name |
Endocytosis - Saccharomyces cerevisiae (budding yeast)
|
|---|
| Description |
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
|
|---|
| Class |
Cellular Processes; Transport and catabolism
 |
|---|
| Pathway map |
  |
|---|
| Module |
|
|---|
| Other DBs |
|
|---|
| Organism |
Saccharomyces cerevisiae (budding yeast) [GN: sce]
|
|---|
| Gene |
| | | MSS4; 1-phosphatidylinositol-4-phosphate 5-kinase [KO: K00889] [EC: 2.7.1.68] | | | | | | | | | | RSP5; NEDD4 family E3 ubiquitin-protein ligase [KO: K10591] [EC: 6.3.2.19] | | | | SSA2; Hsp70 family chaperone SSA2 [KO: K03283] | | SSA1; Hsp70 family ATPase SSA1 [KO: K03283] | | SSA4; Hsp70 family chaperone SSA4 [KO: K03283] | | SSA3; Hsp70 family ATPase SSA3 [KO: K03283] | | SSB2; Hsp70 family ATPase SSB2 [KO: K03283] | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | hypothetical protein; K15053 charged multivesicular body protein 7 [KO: K15053] | | VPS4; AAA family ATPase VPS4 [KO: K12196] | | | | | | | | | | | | | | | | | | |
|
|---|
| Compound |
| ATP | | ADP | | Folate | | 1-Phosphatidyl-1D-myo-inositol 3-phosphate | | 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate | | Phosphatidylinositol-3,4,5-trisphosphate | | GM1 |
|
|---|
| Reference |
|
|---|
| Authors |
Acconcia F, Sigismund S, Polo S |
|---|
| Title |
Ubiquitin in trafficking: the network at work. |
|---|
| Journal |
Exp Cell Res 315:1610-8 (2009) |
|---|
| Reference |
|
|---|
| Authors |
Donaldson JG, Porat-Shliom N, Cohen LA |
|---|
| Title |
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling. |
|---|
| Journal |
Cell Signal 21:1-6 (2009) |
|---|
| Reference |
|
|---|
| Authors |
Sorkin A |
|---|
| Title |
Cargo recognition during clathrin-mediated endocytosis: a team effort. |
|---|
| Journal |
Curr Opin Cell Biol 16:392-9 (2004) |
|---|
| Reference |
|
|---|
| Authors |
Raiborg C, Stenmark H |
|---|
| Title |
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. |
|---|
| Journal |
Nature 458:445-52 (2009) |
|---|
| Reference |
(Japanese) |
|---|
| Authors |
Ohno H, Yoshimori T (eds). |
|---|
| Title |
[Current Stream in Membrane Traffic] (in Japanese) |
|---|
| Journal |
Tanpakushitsu Kakusan Koso 53 (2008) |
|---|
| Reference |
|
|---|
| Authors |
Scita G, Di Fiore PP |
|---|
| Title |
The endocytic matrix. |
|---|
| Journal |
Nature 463:464-73 (2010) |
|---|
| Reference |
|
|---|
| Authors |
Le Roy C, Wrana JL |
|---|
| Title |
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. |
|---|
| Journal |
Nat Rev Mol Cell Biol 6:112-26 (2005) |
|---|
| Reference |
|
|---|
| Authors |
Jovic M, Sharma M, Rahajeng J, Caplan S |
|---|
| Title |
The early endosome: a busy sorting station for proteins at the crossroads. |
|---|
| Journal |
Histol Histopathol 25:99-112 (2010) |
|---|
| Reference |
|
|---|
| Authors |
Pietiainen VM, Marjomaki V, Heino J, Hyypia T |
|---|
| Title |
Viral entry, lipid rafts and caveosomes. |
|---|
| Journal |
Ann Med 37:394-403 (2005) |
|---|
| KO pathway |
|
|---|
