KEGG   PATHWAY: sco00010Help
Entry
sco00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Streptomyces coelicolor
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Glycolysis / Gluconeogenesis
sco00010

All organismsOrtholog table
Module
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:sco00010]
Glycolysis, core module involving three-carbon compounds [PATH:sco00010]
Gluconeogenesis, oxaloacetate => fructose-6P [PATH:sco00010]
PTS system, maltose and glucose-specific II component [PATH:sco00010]
Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:sco00010]
Other DBs
BSID: 
GO: 
Organism
Streptomyces coelicolor [GN:sco]
Gene
glk; glucokinase [KO:K00845] [EC:2.7.1.2]
SCG22.23c; sugar kinase [KO:K00845] [EC:2.7.1.2]
SCAH10.25; sugar kinase [KO:K00845] [EC:2.7.1.2]
SCD95A.18c; sugar kinase [KO:K00845] [EC:2.7.1.2]
SCJ4.44c; glucokinase [KO:K00845] [EC:2.7.1.2]
SCBAC1A6.34c; sugar kinase [KO:K00845] [EC:2.7.1.2]
pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
pfkA; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
pfkA2; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
2SCG58.14; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
glpX; fructose 1,6-bisphosphatase II [KO:K02446] [EC:3.1.3.11]
fba; fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
agaY; tagatose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
tpiA; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
SCF55.02c; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
gap1; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
gap2; glyceraldehyde 3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
gap2; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
pgk; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
SC1A2.27c.; phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
2SCC13.14c; mutase [KO:K15634] [EC:5.4.2.12]
SC2H12.18c; phosphoglycerate mutase [KO:K15634] [EC:5.4.2.12]
pgm2; phosphoglycerate mutase [KO:K15634] [EC:5.4.2.12]
SC9G1.08c; phosphatase [KO:K15634] [EC:5.4.2.12]
SCC30.07c; bifunctional RNase H/acid phosphatase [KO:K15634] [EC:5.4.2.12]
SC10F4.03; isomerase [KO:K15634] [EC:5.4.2.12]
eno; phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
eno; phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
pyk2; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
pyk1; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
aceE; pyruvate dehydrogenase subunit E1 [KO:K00163] [EC:1.2.4.1]
aceE1; 2-oxoacid dehydrogenase subunit E1 [KO:K00163] [EC:1.2.4.1]
aceE; pyruvate dehydrogenase subunit E1 [KO:K00163] [EC:1.2.4.1]
2SCG18.17c; pyruvate dehydrogenase subunit alpha [KO:K00161] [EC:1.2.4.1]
bkdA1; branched-chain alpha-keto acid dehydrogenase E1 subunit alpha [KO:K00161] [EC:1.2.4.1]
bkdA2; E1-alpha branched-chain alpha keto acid dehydrogenase [KO:K00161] [EC:1.2.4.1]
2SCG18.16c; pyruvate dehydrogenase subunit beta [KO:K00162] [EC:1.2.4.1]
bkdB1; branched-chain alpha-keto acid dehydrogenase E1 subunit beta [KO:K00162] [EC:1.2.4.1]
bkdB2; branched-chain alpha-keto acid dehydrogenase E1 subunit beta [KO:K00162] [EC:1.2.4.1]
bkdC1; branched-chain alpha-keto acid dehydrogenase E2 [KO:K00627] [EC:2.3.1.12]
bkdC2; branched-chain alpha-keto acid dehydrogenase E2 [KO:K00627] [EC:2.3.1.12]
SCK13.11; flavoprotein disulfide reductase [KO:K00382] [EC:1.8.1.4]
SCM1.17c; oxidoreductase [KO:K00382] [EC:1.8.1.4]
pdhL; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SCI30A.26c; alcohol dehydrogenase [KO:K00121] [EC:1.1.1.1 1.1.1.284]
SCJ12.11c; alcohol dehydrogenase [KO:K13953] [EC:1.1.1.1]
SC9H11.16c.; oxidoreductase [KO:K13953] [EC:1.1.1.1]
SCK13.05c; aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SCI30A.27c; aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SCE9.27c; aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SC5H4.03; aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SCG11A.05; aldehyde dehydrogenase [KO:K00138] [EC:1.2.1.-]
SC2G5.16; acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
acsA; acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
SC4A7.21; aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
SC4A7.35; aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
ppgK; polyphosphate glucokinase [KO:K00886] [EC:2.7.1.63]
2SCK36.02; phosphoenolpyruvate carboxykinase [KO:K01596] [EC:4.1.1.32]
SC5A7.20; glucosidase [KO:K01222] [EC:3.2.1.86]
SC6D10.04; sugar hydrolase [KO:K01222] [EC:3.2.1.86]
SC1A8A.10; PTS system sugar phosphotransferase component IIA [KO:K02777] [EC:2.7.1.69]
malX; bifunctional PTS system maltose and glucose-specific transporter subunits IICB [KO:K02790 K02791] [EC:2.7.1.69]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00031  
D-Glucose
C00033  
Acetate
C00036  
Oxaloacetate
C00068  
Thiamin diphosphate
C00074  
Phosphoenolpyruvate
C00084  
Acetaldehyde
C00103  
D-Glucose 1-phosphate
C00111  
Glycerone phosphate
C00118  
D-Glyceraldehyde 3-phosphate
C00186  
(S)-Lactate
C00197  
3-Phospho-D-glycerate
C00221  
beta-D-Glucose
C00236  
3-Phospho-D-glyceroyl phosphate
C00267  
alpha-D-Glucose
C00469  
Ethanol
C00631  
2-Phospho-D-glycerate
C00668  
alpha-D-Glucose 6-phosphate
C01159  
2,3-Bisphospho-D-glycerate
C01172  
beta-D-Glucose 6-phosphate
C01451  
Salicin
C05125  
2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  
beta-D-Fructose 6-phosphate
C05378  
beta-D-Fructose 1,6-bisphosphate
C06186  
Arbutin
C06187  
Arbutin 6-phosphate
C06188  
Salicin 6-phosphate
C15972  
Enzyme N6-(lipoyl)lysine
C15973  
Enzyme N6-(dihydrolipoyl)lysine
C16255  
[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
 

DBGET integrated database retrieval system