KEGG   PATHWAY: sdn03440Help
Entry
sdn03440                    Pathway                                

Name
Homologous recombination - Shewanella denitrificans
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
sdn03440  Homologous recombination
sdn03440

Ortholog table
Module
sdn_M00260  DNA polymerase III complex, bacteria [PATH:sdn03440]
Other DBs
BSID: 33533
GO: 0000724
Organism
Shewanella denitrificans [GN:sdn]
Gene
Sden_0749  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Sden_3313  single-strand binding protein [KO:K03111]
Sden_0003  DNA replication and repair protein RecF [KO:K03629]
Sden_2764  DNA repair protein RecO [KO:K03584]
Sden_1427  recombination protein RecR [KO:K06187]
Sden_1208  recA protein [KO:K03553]
Sden_3620  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Sden_1884  Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
Sden_1883  Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
Sden_1885  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
Sden_3476  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
Sden_2352  exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
Sden_2351  exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
Sden_2353  exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
Sden_1569  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Sden_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Sden_2381  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Sden_0795  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Sden_2050  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
Sden_3773  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Sden_2018  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Sden_2866  DNA polymerase III chi subunit, HolC [KO:K02339] [EC:2.7.7.7]
Sden_3356  primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Sden_0516  restart primosome assembly protein PriB [KO:K02686]
Sden_2431  primosomal replication protein N'', putative [KO:K04067]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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