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see03440                    Pathway                                

Homologous recombination - Salmonella enterica subsp. enterica serovar Newport SL254
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Genetic Information Processing; Replication and repair
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Pathway map
see03440  Homologous recombination

Ortholog table
see_M00260  DNA polymerase III complex, bacteria [PATH:see03440]
Other DBs
BSID: 71788
GO: 0000724
Salmonella enterica subsp. enterica serovar Newport SL254 [GN:see]
SNSL254_A3276  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
SNSL254_A4599  ssb2; single-stranded DNA-binding protein [KO:K03111]
SNSL254_A4121  DNA replication and repair protein RecF [KO:K03629]
SNSL254_A2782  recO; DNA repair protein RecO [KO:K03584]
SNSL254_A0537  recR; recombination protein RecR [KO:K06187]
SNSL254_A3031  recA; protein RecA [KO:K03553]
SNSL254_A4281  DNA polymerase I [KO:K02335] [EC:]
SNSL254_A2054  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:]
SNSL254_A2053  ruvB; holliday junction DNA helicase RuvB [KO:K03551] [EC:]
SNSL254_A2057  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:]
SNSL254_A4024  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:]
SNSL254_A3220  recB; exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:]
SNSL254_A3222  recC; exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:]
SNSL254_A3219  recD; exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:]
SNSL254_A0253  dnaE; DNA polymerase III, alpha subunit [KO:K02337] [EC:]
SNSL254_A4122  dnaN; DNA polymerase III, beta subunit [KO:K02338] [EC:]
SNSL254_A0534  dnaX; DNA polymerase III, tau subunit [KO:K02343] [EC:]
SNSL254_A0703  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:]
SNSL254_A1300  DNA polymerase III subunit delta' [KO:K02341] [EC:]
SNSL254_A0289  dnaQ; DNA polymerase III, epsilon subunit [KO:K02342] [EC:]
SNSL254_A2035  conserved domain protein [KO:K02345] [EC:]
SNSL254_A4825  holC; DNA polymerase III, chi subunit [KO:K02339] [EC:]
SNSL254_A4913  holD; DNA polymerase III, psi subunit [KO:K02344] [EC:]
SNSL254_A4425  primosomal protein N' [KO:K04066] [EC:3.6.4.-]
SNSL254_A4752  priB; primosomal replication protein N [KO:K02686]
SNSL254_A0531  primosomal replication protein N'' [KO:K04067]
SNSL254_A4899  primosomal protein 1 [KO:K02317]
Maloisel L, Fabre F, Gangloff S.
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Mol Cell Biol 28:1373-82 (2008)
Haruta-Takahashi N, Iwasaki H.
[Recombination mediators] Japanese
Seikagaku 79:449-53 (2007)
Ouyang KJ, Woo LL, Ellis NA.
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Mech Ageing Dev 129:425-40 (2008)
Kawabata M, Kawabata T, Nishibori M.
Role of recA/RAD51 family proteins in mammals.
Acta Med Okayama 59:1-9 (2005)
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Mitotic recombination in Saccharomyces cerevisiae.
Curr Genet 42:185-98 (2003)
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Rad54: the Swiss Army knife of homologous recombination?
Nucleic Acids Res 34:4115-25 (2006)
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Recombination proteins and rescue of arrested replication forks.
DNA Repair (Amst) 6:967-80 (2007)
KO pathway

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