KEGG   PATHWAY: seg02060Help
Entry
seg02060                    Pathway                                

Name
Phosphotransferase system (PTS) - Salmonella enterica subsp. enterica serovar Gallinarum 287/91
Description
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Phosphotransferase system (PTS)
seg02060

All organismsOrtholog table
Module
PTS system, glucose-specific II component [PATH:seg02060]
PTS system, N-acetylglucosamine-specific II component [PATH:seg02060]
PTS system, trehalose-specific II component [PATH:seg02060]
PTS system, fructose-specific II component [PATH:seg02060]
PTS system, mannitol-specific II component [PATH:seg02060]
PTS system, cellobiose-specific II component [PATH:seg02060]
PTS system, mannose-specific II component [PATH:seg02060]
PTS system, galactitol-specific II component [PATH:seg02060]
PTS system, glucitol/sorbitol-specific II component [PATH:seg02060]
PTS system, ascorbate-specific II component [PATH:seg02060]
PTS system, D-glucosaminate-specific II component [PATH:seg02060]
Other DBs
BSID: 
GO: 
TC: 
Organism
Salmonella enterica subsp. enterica serovar Gallinarum 287/91 [GN:seg]
Gene
SG2464  
ptsI; phosphoenolpyruvate-protein phosphotransferase [KO:K08483] [EC:2.7.3.9]
SG2463  
ptsH; PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr [KO:K02784]
SG2465  
crr; PTS system glucose-specific transporter subunit [KO:K02777] [EC:2.7.1.69]
SG1919  
ptsG; PTS system glucose-specific transporter subunits IIBC [KO:K02778 K02779] [EC:2.7.1.69]
SG0682  
nagE; PTS system N-acetyl glucosamine specific transporter subunits IIABC [KO:K02802 K02803 K02804] [EC:2.7.1.69 2.7.1.69]
SG2607  
PTS system transporter subunit IIBC; K02809 PTS system, sucrose-specific IIB component [EC:2.7.1.69] K02810 PTS system, sucrose-specific IIC component [KO:K02809 K02810] [EC:2.7.1.69]
SG4280  
treB; PTS system trehalose(maltose)-specific transporter subunits IIBC [KO:K02818 K02819] [EC:2.7.1.69]
SG1802  
celC; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA [KO:K02759] [EC:2.7.1.69]
SG1804  
celA; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB [KO:K02760] [EC:2.7.1.69]
SG1803  
celB; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC [KO:K02761]
SG3745  
mtlA; mannitol-specific enzyme II of phosphotransferase system [KO:K02798 K02799 K02800] [EC:2.7.1.69 2.7.1.69]
SG1287  
manX; PTS system mannose-specific transporter subunit IIAB [KO:K02793 K02794] [EC:2.7.1.69 2.7.1.69]
SG4365  
PTS transport system transporter subunit IIA; K02793 PTS system, mannose-specific IIA component [EC:2.7.1.69] [KO:K02793] [EC:2.7.1.69]
SG4366  
PTS transport system transporter subunit IIB; K02794 PTS system, mannose-specific IIB component [EC:2.7.1.69] [KO:K02794] [EC:2.7.1.69]
SG1286  
manY; phosphotransferase enzyme II, C component [KO:K02795]
SG4367  
PTS transport system transporter subunit IIC; K02795 PTS system, mannose-specific IIC component [KO:K02795]
SG1285  
manZ; PTS system mannose-specific transporter subunit IID [KO:K02796]
SG4368  
PTS transport system transporter subunit IID; K02796 PTS system, mannose-specific IID component [KO:K02796]
SG3656  
PTS system transporter protein; K17464 PTS system, D-glucosaminate-specific IIA component [EC:2.7.1.69] [KO:K17464] [EC:2.7.1.69]
SG3657  
PTS system transporter protein; K17465 PTS system, D-glucosaminate-specific IIB component [EC:2.7.1.69] [KO:K17465] [EC:2.7.1.69]
SG3658  
PTS system transporter protein; K17466 PTS system, D-glucosaminate-specific IIC component [KO:K17466]
SG3659  
PTS system transporter protein; K17467 PTS system, D-glucosaminate-specific IID component [KO:K17467]
SG2737  
slrB; PTS system glucitol/sorbitol-specific transporter subunit IIA [KO:K02781] [EC:2.7.1.69]
SG2736  
srlE; PTS system, glucitol/sorbitol-specific IIBC component [KO:K02782 K02783] [EC:2.7.1.69]
SG2735  
srlA; PTS system, glucitol/sorbitol-specific IIBC component [KO:K02783]
SG1507  
phosphotransferase; K02773 PTS system, galactitol-specific IIA component [EC:2.7.1.69] [KO:K02773] [EC:2.7.1.69]
SG3149  
PTS system galactitol-specific transporter subunit IIA; K02773 PTS system, galactitol-specific IIA component [EC:2.7.1.69] [KO:K02773] [EC:2.7.1.69]
SG1510  
phosphotransferase; K02774 PTS system, galactitol-specific IIB component [EC:2.7.1.69] [KO:K02774] [EC:2.7.1.69]
SG3150  
PTS system galactitol-specific transporter subunit IIB; K02774 PTS system, galactitol-specific IIB component [EC:2.7.1.69] [KO:K02774] [EC:2.7.1.69]
SG1509  
phosphotransferase; K02775 PTS system, galactitol-specific IIC component [KO:K02775]
SG3151  
PTS system; K02775 PTS system, galactitol-specific IIC component [KO:K02775]
SG2373  
sugar phosphotransferase subunit IIA; K02821 PTS system, ascorbate-specific IIA component [EC:2.7.1.69] [KO:K02821] [EC:2.7.1.69]
SG4227  
ptxA; PTS system L-ascorbate-specific transporter subunit IIA [KO:K02821] [EC:2.7.1.69]
SG0865  
phosphotransferase enzyme subunit IIB; K02822 PTS system, ascorbate-specific IIB component [EC:2.7.1.69] [KO:K02822] [EC:2.7.1.69]
SG2372  
sugar phosphotransferase subunit IIB; K02822 PTS system, ascorbate-specific IIB component [EC:2.7.1.69] [KO:K02822] [EC:2.7.1.69]
SG4226  
sgaB; PTS system L-ascorbate-specific transporter subunit IIB [KO:K02822] [EC:2.7.1.69]
SG0864  
PTS system ascorbate-specific transporter subunit IIC; K03475 PTS system, ascorbate-specific IIC component [KO:K03475]
SG2371  
ulaA; PTS system ascorbate-specific transporter subunit IIC [KO:K03475]
SG4225  
ulaA; PTS system ascorbate-specific transporter subunit IIC [KO:K03475]
SG2243  
fruF; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein [KO:K02768 K11183] [EC:2.7.1.69]
SG2241  
fruA; PTS system fructose-specific transporter subunits IIBC [KO:K02769 K02770] [EC:2.7.1.69]
SG2911  
ptsP; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain [KO:K08484] [EC:2.7.3.9]
SG3214  
ptsO; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) [KO:K08485]
SG3212  
ptsN; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN [KO:K02806] [EC:2.7.1.69]
Compound
C00022  
Pyruvate
C00031  
D-Glucose
C00072  
Ascorbate
C00074  
Phosphoenolpyruvate
C00089  
Sucrose
C00092  
D-Glucose 6-phosphate
C00095  
D-Fructose
C00140  
N-Acetyl-D-glucosamine
C00159  
D-Mannose
C00185  
Cellobiose
C00208  
Maltose
C00243  
Lactose
C00275  
D-Mannose 6-phosphate
C00329  
D-Glucosamine
C00352  
D-Glucosamine 6-phosphate
C00357  
N-Acetyl-D-glucosamine 6-phosphate
C00392  
Mannitol
C00644  
D-Mannitol 1-phosphate
C00689  
alpha,alpha'-Trehalose 6-phosphate
C00697  
Nitrogen
C00794  
D-Sorbitol
C00963  
beta-D-Glucoside
C01083  
alpha,alpha-Trehalose
C01094  
D-Fructose 1-phosphate
C01096  
Sorbitol 6-phosphate
C01132  
N-Acetyl-D-galactosamine
C01135  
Phospho-beta-D-glucoside
C01451  
Salicin
C01452  
Sorbose
C01697  
Galactitol
C02262  
D-Galactosamine
C02713  
N-Acetylmuramate
C02888  
Sorbose 1-phosphate
C03752  
2-Amino-2-deoxy-D-gluconate
C05396  
Lactose 6-phosphate
C05737  
Maltose 6-phosphate
C06186  
Arbutin
C06187  
Arbutin 6-phosphate
C06188  
Salicin 6-phosphate
C06311  
Galactitol 1-phosphate
C06376  
N-Acetyl-D-galactosamine 6-phosphate
C06377  
D-Galactosamine 6-phosphate
C11544  
2(alpha-D-Mannosyl)-D-glycerate
C16186  
L-Ascorbate 6-phosphate
C16688  
Sucrose 6-phosphate
C16698  
N-Acetylmuramic acid 6-phosphate
C16699  
2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  
6-Phospho-D-glucosaminate
Reference
  Authors
Darbon E, Galinier A, Le Coq D, Deutscher J.
  Title
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
  Journal
J Mol Microbiol Biotechnol 3:439-44 (2001)
Reference
  Authors
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
  Title
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
  Journal
J Bacteriol 186:2385-92 (2004)
Reference
PMID:2117666
  Authors
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
  Title
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
  Journal
J Mol Biol 214:657-71 (1990)
Reference
  Authors
Kristich CJ, Glekas GD, Ordal GW.
  Title
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 47:1353-66 (2003)
Reference
  Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
  Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
  Journal
J Biol Chem 279:5537-48 (2004)
Reference
  Authors
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
  Title
EcoCyc: a comprehensive database resource for Escherichia coli.
  Journal
Nucleic Acids Res 33:D334-7 (2005)
Reference
  Authors
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
  Title
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
  Journal
J Bacteriol 190:1710-7 (2008)
Reference
  Authors
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
  Title
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
  Journal
Mol Microbiol 37:125-35 (2000)
Reference
  Authors
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
  Title
The complete phosphotranferase system in Escherichia coli.
  Journal
J Mol Microbiol Biotechnol 3:329-46 (2001)
Reference
  Authors
Kotrba P, Inui M, Yukawa H.
  Title
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
  Journal
J Biosci Bioeng 92:502-17 (2001)
KO pathway
 

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