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Entry
sej02060                    Pathway                                

Name
Phosphotransferase system (PTS) - Salmonella enterica subsp. enterica serovar Typhimurium UK-1
Description
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
sej02060  Phosphotransferase system (PTS)
sej02060

Ortholog table
Module
sej_M00265  PTS system, glucose-specific II component [PATH:sej02060]
sej_M00267  PTS system, N-acetylglucosamine-specific II component [PATH:sej02060]
sej_M00273  PTS system, fructose-specific II component [PATH:sej02060]
sej_M00274  PTS system, mannitol-specific II component [PATH:sej02060]
sej_M00275  PTS system, cellobiose-specific II component [PATH:sej02060]
sej_M00276  PTS system, mannose-specific II component [PATH:sej02060]
sej_M00279  PTS system, galactitol-specific II component [PATH:sej02060]
sej_M00280  PTS system, glucitol/sorbitol-specific II component [PATH:sej02060]
sej_M00283  PTS system, ascorbate-specific II component [PATH:sej02060]
sej_M00610  PTS system, D-glucosaminate-specific II component [PATH:sej02060]
sej_M00764  PTS system, fructoselysine/glucoselysine-specific II component [PATH:sej02060]
Other DBs
BSID: 567010
GO: 0009401
TC: 4.A
Organism
Salmonella enterica subsp. enterica serovar Typhimurium UK-1 [GN:sej]
Gene
STMUK_2464  ptsI; phosphoenolpyruvate-protein phosphotransferase [KO:K08483] [EC:2.7.3.9]
STMUK_4096  ptsA; PEP-protein phosphotransferase [KO:K08483 K11189 K11201] [EC:2.7.3.9 2.7.1.-]
STMUK_2463  ptsH; PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr [KO:K02784]
STMUK_2465  crr; PTS system glucose-specific transporter subunit [KO:K02777] [EC:2.7.1.-]
STMUK_1171  ptsG; PTS system glucose-specific transporter subunits IIBC [KO:K02778 K02779] [EC:2.7.1.199]
STMUK_0690  nagE; PTS system N-acetyl glucosamine specific transporter subunits IIABC [KO:K02802 K02803 K02804] [EC:2.7.1.193 2.7.1.193]
STMUK_2602  putative phosphotransferase system IIB component [KO:K02809 K02810] [EC:2.7.1.211]
STMUK_3671  mtlA; mannitol-specific enzyme IIABC component [KO:K02798 K02799 K02800] [EC:2.7.1.197 2.7.1.197]
STMUK_1281  celC; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA [KO:K02759] [EC:2.7.1.205 2.7.1.196]
STMUK_1279  celA; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB [KO:K02760] [EC:2.7.1.205 2.7.1.196]
STMUK_1280  celB; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC [KO:K02761]
STMUK_0582  putative PTS system mannose-specific enzyme IIAB [KO:K02793] [EC:2.7.1.191]
STMUK_1803  manX; mannose-specific enzyme IIAB [KO:K02793 K02794] [EC:2.7.1.191 2.7.1.191]
STMUK_0581  putative PTS system mannose-specific enzyme IIAB [KO:K02794] [EC:2.7.1.191]
STMUK_0580  putative inner membrane protein [KO:K02795]
STMUK_1804  manY; mannose-specific enzyme IIC [KO:K02795]
STMUK_1805  manZ; PTS system mannose-specific transporter subunit IID [KO:K02796]
STMUK_4522  putative PTS permease [KO:K19506] [EC:2.7.1.-]
STMUK_4523  putative PTS permease [KO:K19507] [EC:2.7.1.-]
STMUK_4524  putative PTS permease [KO:K19508]
STMUK_0579  putative PTS system mannose-specific enzyme IID [KO:K19509]
STMUK_4525  putative PTS permease [KO:K19509]
STMUK_3758  putative phosphotransferase system enzyme IIA [KO:K17464] [EC:2.7.1.203]
STMUK_3757  putative phosphotransferase system enzyme IIB [KO:K17465] [EC:2.7.1.203]
STMUK_3756  putative phosphotransferase system enzyme IIC [KO:K17466]
STMUK_3755  putative phosphotransferase system enzyme II [KO:K17467]
STMUK_2739  putative glucitol-specific PTS enzyme III [KO:K02781] [EC:2.7.1.198]
STMUK_2823  slrB; PTS system glucitol/sorbitol-specific transporter subunit IIA [KO:K02781] [EC:2.7.1.198]
STMUK_2822  srlE; glucitol/sorbitol-specific enzyme IIB component [KO:K02782 K02783] [EC:2.7.1.198]
STMUK_2740  putative glucitol-specific PTS enzyme III [KO:K02782 K02783] [EC:2.7.1.198]
STMUK_2821  srlA; glucitol/sorbitol-specific enzyme IIC component [KO:K02783]
STMUK_2738  putative PTS system glucitol/sorbitol-specific enzyme II [KO:K02783]
STMUK_1585  putative sugar-specific PTS enzyme II [KO:K02773] [EC:2.7.1.200]
STMUK_3770  phosphotransferase system mannitol/fructose-specific IIA component [KO:K02773] [EC:2.7.1.200]
STMUK_1582  putative PTS system enzymeIIB component [KO:K02774] [EC:2.7.1.200]
STMUK_3769  putative periplasmic protein [KO:K02774] [EC:2.7.1.200]
STMUK_1583  putative PTS system enzyme IIC component [KO:K02775]
STMUK_3768  putative PTS system galactitol-specific enzyme IIC component [KO:K02775]
STMUK_2374  putative phosphotransferase system enzyme II A component [KO:K02821] [EC:2.7.1.194]
STMUK_4370  ptxA; PTS system L-ascorbate-specific transporter subunit IIA [KO:K02821] [EC:2.7.1.194]
STMUK_2373  putative cytoplasmic protein [KO:K02822] [EC:2.7.1.194]
STMUK_4369  sgaB; PTS system L-ascorbate-specific transporter subunit IIB [KO:K02822] [EC:2.7.1.194]
STMUK_0890  putative inner membrane protein [KO:K02822] [EC:2.7.1.194]
STMUK_2372  sgaT; PTS system ascorbate-specific transporter subunit IIC [KO:K03475]
STMUK_4368  sgaT; PTS system ascorbate-specific transporter subunit IIC [KO:K03475]
STMUK_0889  sgaT; PTS system ascorbate-specific transporter subunit IIC [KO:K03475]
STMUK_2236  fruF; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein [KO:K02768 K11183] [EC:2.7.1.202]
STMUK_3847  putative phosphotransferase system fructose-specific component IIB [KO:K02769 K02770] [EC:2.7.1.202]
STMUK_2234  fruA; PTS system fructose-specific transporter subunits IIBC [KO:K02769 K02770] [EC:2.7.1.202]
STMUK_2991  ptsP; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain protein [KO:K08484] [EC:2.7.3.9]
STMUK_3310  ptsO; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) [KO:K08485]
STMUK_3308  ptsN; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN [KO:K02806] [EC:2.7.1.-]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Reference
  Authors
Darbon E, Galinier A, Le Coq D, Deutscher J.
  Title
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
  Journal
J Mol Microbiol Biotechnol 3:439-44 (2001)
Reference
  Authors
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
  Title
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
  Journal
J Bacteriol 186:2385-92 (2004)
DOI:10.1128/JB.186.8.2385-2392.2004
Reference
PMID:2117666
  Authors
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
  Title
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
  Journal
J Mol Biol 214:657-71 (1990)
DOI:10.1016/0022-2836(90)90284-S
Reference
  Authors
Kristich CJ, Glekas GD, Ordal GW.
  Title
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 47:1353-66 (2003)
DOI:10.1046/j.1365-2958.2003.03375.x
Reference
  Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
  Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
  Journal
J Biol Chem 279:5537-48 (2004)
DOI:10.1074/jbc.M310980200
Reference
  Authors
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
  Title
EcoCyc: a comprehensive database resource for Escherichia coli.
  Journal
Nucleic Acids Res 33:D334-7 (2005)
DOI:10.1093/nar/gki108
Reference
  Authors
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
  Title
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
  Journal
J Bacteriol 190:1710-7 (2008)
DOI:10.1128/JB.01737-07
Reference
  Authors
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
  Title
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
  Journal
Mol Microbiol 37:125-35 (2000)
DOI:10.1046/j.1365-2958.2000.01969.x
Reference
  Authors
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
  Title
The complete phosphotranferase system in Escherichia coli.
  Journal
J Mol Microbiol Biotechnol 3:329-46 (2001)
Reference
  Authors
Kotrba P, Inui M, Yukawa H.
  Title
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
  Journal
J Biosci Bioeng 92:502-17 (2001)
DOI:10.1016/S1389-1723(01)80308-X
KO pathway
ko02060   

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