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Entry
seo02060                    Pathway                                

Name
Phosphotransferase system (PTS) - Salmonella enterica subsp. enterica serovar Typhimurium 14028S
Description
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
seo02060  Phosphotransferase system (PTS)
seo02060

Ortholog table
Module
seo_M00265  PTS system, glucose-specific II component [PATH:seo02060]
seo_M00267  PTS system, N-acetylglucosamine-specific II component [PATH:seo02060]
seo_M00273  PTS system, fructose-specific II component [PATH:seo02060]
seo_M00274  PTS system, mannitol-specific II component [PATH:seo02060]
seo_M00275  PTS system, cellobiose-specific II component [PATH:seo02060]
seo_M00276  PTS system, mannose-specific II component [PATH:seo02060]
seo_M00279  PTS system, galactitol-specific II component [PATH:seo02060]
seo_M00280  PTS system, glucitol/sorbitol-specific II component [PATH:seo02060]
seo_M00283  PTS system, ascorbate-specific II component [PATH:seo02060]
seo_M00610  PTS system, D-glucosaminate-specific II component [PATH:seo02060]
seo_M00764  PTS system, fructoselysine/glucoselysine-specific II component [PATH:seo02060]
Other DBs
BSID: 553108
GO: 0009401
TC: 4.A
Organism
Salmonella enterica subsp. enterica serovar Typhimurium 14028S [GN:seo]
Gene
STM14_2990  ptsI; phosphoenolpyruvate-protein phosphotransferase [KO:K08483] [EC:2.7.3.9]
STM14_4941  ptsA; PEP-protein phosphotransferase [KO:K08483 K11189 K11201] [EC:2.7.3.9 2.7.1.-]
STM14_2989  ptsH; phosphohistidinoprotein-hexose phosphotransferase component of PTS system (Hpr) [KO:K02784]
STM14_2991  crr; glucose-specific PTS system component [KO:K02777] [EC:2.7.1.-]
STM14_1377  ptsG; glucose-specific PTS system IIBC components [KO:K02778 K02779] [EC:2.7.1.199]
STM14_0798  nagE; N-acetyl glucosamine specific PTS system components IIABC [KO:K02802 K02803 K02804] [EC:2.7.1.193 2.7.1.193]
STM14_3150  putative phosphotransferase system IIB component [KO:K02809 K02810] [EC:2.7.1.211]
STM14_4443  mtlA; mannitol-specific enzyme IIABC component [KO:K02798 K02799 K02800] [EC:2.7.1.197 2.7.1.197]
STM14_1596  celC; N,N'-diacetylchitobiose-specific PTS system transporter subunit IIA [KO:K02759] [EC:2.7.1.205 2.7.1.196]
STM14_1594  celA; N,N'-diacetylchitobiose-specific PTS system transporter subunit IIB [KO:K02760] [EC:2.7.1.205 2.7.1.196]
STM14_1595  celB; N,N'-diacetylchitobiose-specific PTS system transporter subunit IIC [KO:K02761]
STM14_2212  manX; mannose-specific enzyme IIAB [KO:K02793 K02794] [EC:2.7.1.191 2.7.1.191]
STM14_0673  putative PTS system mannose-specific enzyme IIAB [KO:K02793] [EC:2.7.1.191]
STM14_0672  putative PTS system mannose-specific enzyme IIAB [KO:K02794] [EC:2.7.1.191]
STM14_2213  manY; mannose-specific enzyme IIC [KO:K02795]
STM14_0671  putative inner membrane protein [KO:K02795]
STM14_2214  manZ; mannose-specific PTS system protein IID [KO:K02796]
STM14_5449  putative PTS permease [KO:K19506] [EC:2.7.1.-]
STM14_5450  putative PTS permease [KO:K19507] [EC:2.7.1.-]
STM14_5451  putative PTS permease [KO:K19508]
STM14_0670  putative PTS system mannose-specific enzyme IID [KO:K19509]
STM14_5452  putative PTS permease [KO:K19509]
STM14_4548  putative phosphotransferase system enzyme IIA [KO:K17464] [EC:2.7.1.203]
STM14_4547  putative phosphotransferase system enzyme IIB [KO:K17465] [EC:2.7.1.203]
STM14_4546  putative phosphotransferase system enzyme IIC [KO:K17466]
STM14_4545  putative phosphotransferase system enzyme II [KO:K17467]
STM14_3316  putative glucitol-specific PTS enzyme III [KO:K02781] [EC:2.7.1.198]
STM14_3424  slrB; glucitol/sorbitol-specific PTS system component IIA [KO:K02781] [EC:2.7.1.198]
STM14_3423  srlE; glucitol/sorbitol-specific enzyme IIB component [KO:K02782 K02783] [EC:2.7.1.198]
STM14_3317  putative glucitol-specific PTS enzyme III [KO:K02782 K02783] [EC:2.7.1.198]
STM14_3422  srlA; glucitol/sorbitol-specific enzyme IIC component [KO:K02783]
STM14_3315  putative PTS system glucitol/sorbitol-specific enzyme II [KO:K02783]
STM14_4563  phosphotransferase system mannitol/fructose-specific IIA component [KO:K02773] [EC:2.7.1.200]
STM14_1955  putative sugar-specific PTS enzyme II [KO:K02773] [EC:2.7.1.200]
STM14_4562  putative periplasmic protein [KO:K02774] [EC:2.7.1.200]
STM14_1952  putative PTS system enzymeIIB component [KO:K02774] [EC:2.7.1.200]
STM14_1953  putative PTS system enzyme IIC component [KO:K02775]
STM14_4561  putative PTS system galactitol-specific enzyme IIC component [KO:K02775]
STM14_2889  putative phosphotransferase system enzyme II A component [KO:K02821] [EC:2.7.1.194]
STM14_5267  ptxA; L-ascorbate-specific enzyme IIA component of PTS [KO:K02821] [EC:2.7.1.194]
STM14_1036  putative inner membrane protein [KO:K02822] [EC:2.7.1.194]
STM14_2888  putative cytoplasmic protein [KO:K02822] [EC:2.7.1.194]
STM14_5266  sgaB; L-ascorbate-specific enzyme IIB component of PTS [KO:K02822] [EC:2.7.1.194]
STM14_1035  ulaA_1; ascorbate-specific PTS system enzyme IIC [KO:K03475]
STM14_2887  ulaA_2; ascorbate-specific PTS system enzyme IIC [KO:K03475]
STM14_5265  ulaA_3; ascorbate-specific PTS system enzyme IIC [KO:K03475]
STM14_2723  fruF; bifunctional fructose-specific PTS IIA/HPr protein [KO:K02768 K11183] [EC:2.7.1.202]
STM14_4653  putative phosphotransferase system fructose-specific component IIB [KO:K02769 K02770] [EC:2.7.1.202]
STM14_2721  fruA; fructose-specific PTS system IIBC component [KO:K02769 K02770] [EC:2.7.1.202]
STM14_3620  ptsP; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain-containing protein [KO:K08484] [EC:2.7.3.9]
STM14_4012  ptsO; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) [KO:K08485]
STM14_4010  ptsN; sugar-specific enzyme IIA component of PTS [KO:K02806] [EC:2.7.1.-]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Reference
  Authors
Darbon E, Galinier A, Le Coq D, Deutscher J.
  Title
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
  Journal
J Mol Microbiol Biotechnol 3:439-44 (2001)
Reference
  Authors
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
  Title
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
  Journal
J Bacteriol 186:2385-92 (2004)
DOI:10.1128/JB.186.8.2385-2392.2004
Reference
PMID:2117666
  Authors
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
  Title
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
  Journal
J Mol Biol 214:657-71 (1990)
DOI:10.1016/0022-2836(90)90284-S
Reference
  Authors
Kristich CJ, Glekas GD, Ordal GW.
  Title
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 47:1353-66 (2003)
DOI:10.1046/j.1365-2958.2003.03375.x
Reference
  Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
  Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
  Journal
J Biol Chem 279:5537-48 (2004)
DOI:10.1074/jbc.M310980200
Reference
  Authors
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
  Title
EcoCyc: a comprehensive database resource for Escherichia coli.
  Journal
Nucleic Acids Res 33:D334-7 (2005)
DOI:10.1093/nar/gki108
Reference
  Authors
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
  Title
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
  Journal
J Bacteriol 190:1710-7 (2008)
DOI:10.1128/JB.01737-07
Reference
  Authors
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
  Title
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
  Journal
Mol Microbiol 37:125-35 (2000)
DOI:10.1046/j.1365-2958.2000.01969.x
Reference
  Authors
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
  Title
The complete phosphotranferase system in Escherichia coli.
  Journal
J Mol Microbiol Biotechnol 3:329-46 (2001)
Reference
  Authors
Kotrba P, Inui M, Yukawa H.
  Title
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
  Journal
J Biosci Bioeng 92:502-17 (2001)
DOI:10.1016/S1389-1723(01)80308-X
KO pathway
ko02060   

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