KEGG   PATHWAY: sex03440
Entry
sex03440                    Pathway                                
Name
Homologous recombination - Salmonella enterica subsp. enterica serovar Typhi P-stx-12
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
sex03440  Homologous recombination
sex03440

Other DBs
GO: 0000724
Organism
Salmonella enterica subsp. enterica serovar Typhi P-stx-12 [GN:sex]
Gene
STBHUCCB_31190  Single-stranded-DNA-specific exonuclease recJ [KO:K07462] [EC:3.1.-.-]
STBHUCCB_44010  Single-stranded DNA-binding protein [KO:K03111]
STBHUCCB_44860  Single-stranded DNA-binding protein [KO:K03111]
STBHUCCB_38750  DNA replication and repair protein recF [KO:K03629]
STBHUCCB_2990  DNA repair protein recO [KO:K03584]
STBHUCCB_25110  hypothetical protein [KO:K06187]
STBHUCCB_28700  hypothetical protein [KO:K03553]
STBHUCCB_38100  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
STBHUCCB_10530  Holliday junction ATP-dependent DNA helicase ruvA [KO:K03550]
STBHUCCB_10540  Holliday junction ATP-dependent DNA helicase ruvB [KO:K03551] [EC:5.6.2.4]
STBHUCCB_10500  Crossover junction endodeoxyribonuclease ruvC [KO:K01159] [EC:3.1.21.10]
STBHUCCB_39820  ATP-dependent DNA helicase recG [KO:K03655] [EC:5.6.2.4]
STBHUCCB_30590  Exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
STBHUCCB_30610  Exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
STBHUCCB_30580  Exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
STBHUCCB_2530  DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
STBHUCCB_38740  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
STBHUCCB_25130  DNA polymerase III subunit gamma [KO:K02343] [EC:2.7.7.7]
STBHUCCB_23480  DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
STBHUCCB_18280  DNA polymerase III subunit delta'''' [KO:K02341] [EC:2.7.7.7]
STBHUCCB_27530  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
STBHUCCB_10720  hypothetical protein [KO:K02345] [EC:2.7.7.7]
STBHUCCB_47670  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
STBHUCCB_48530  DNA polymerase III subunit psi [KO:K02344] [EC:2.7.7.7]
STBHUCCB_37050  Primosomal protein N' [KO:K04066] [EC:5.6.2.4]
STBHUCCB_46940  Primosomal replication protein n [KO:K02686]
STBHUCCB_25160  Primosomal replication protein N'' [KO:K04067]
STBHUCCB_48430  hypothetical protein [KO:K02317]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG GENES (28)   
All databases (29)   

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