KEGG   PATHWAY: sfv00401Help
Entry
sfv00401                    Pathway                                

Name
Novobiocin biosynthesis - Shigella flexneri 8401 (serotype 5b)
Class
Metabolism; Biosynthesis of other secondary metabolites
BRITE hierarchy
Pathway map
Novobiocin biosynthesis
sfv00401

All organismsOrtholog table
Organism
Shigella flexneri 8401 (serotype 5b) [GN:sfv]
Gene
tyrA; bifunctional chorismate mutase/prephenate dehydrogenase [KO:K14187] [EC:1.3.1.12 5.4.99.5]
aspC; aromatic amino acid aminotransferase [KO:K00813] [EC:2.6.1.1]
hisC; histidinol-phosphate aminotransferase [KO:K00817] [EC:2.6.1.9]
tyrB; aromatic amino acid aminotransferase [KO:K00832] [EC:2.6.1.57]
Compound
C00082  
L-Tyrosine
C00148  
L-Proline
C00254  
Prephenate
C01179  
3-(4-Hydroxyphenyl)pyruvate
C05073  
Coumermycin A1
C05080  
Novobiocin
C12032  
Clorobiocin
C12456  
3-Dimethylallyl-4-hydroxyphenylpyruvate
C12457  
3-Dimethylallyl-4-hydroxymandelic acid
C12458  
3-Dimethylallyl-4-hydroxybenzoate
C12459  
3-Dimethylallyl-4-hydroxybenzaldehyde
C12460  
3-Dimethylallyl-beta-hydroxy-L-tyrosyl-[pcp]
C12461  
L-Tyrosyl-[pcp]
C12462  
beta-Hydroxy-L-tyrosyl-[pcp]
C12463  
beta-Keto-L-tyrosyl-[pcp]
C12467  
2-Hydroxy-beta-keto-L-tyrosyl-[pcp]
C12468  
3-Amino-4,7-dihydroxycoumarin
C12469  
3-Amino-4,7-dihydroxy-8-chlorocoumarin
C12470  
L-Prolyl-[pcp]
C12471  
Chlorobiocic acid
C12472  
Novclobiocin 105
C12473  
Novclobiocin 104
C12474  
Novobiocic acid
C12475  
Desmethyldescarbamoylnovobiocin
C12476  
Descarbamoylnovobiocin
C12477  
3-Methylpyrrole-2,4-dicarboxylic acid
C12479  
Coumermic acid
C12480  
Coumermycin D
C12481  
dTDP-5-dimethyl-L-lyxose
C12482  
2-Pyrroline-2-carboxyl-[pcp]
C12483  
Pyrrole-2-carboxyl-[pcp]
C20629  
8-Demethylnovobiocic acid
C20637  
5-[[(4,7-Dihydroxy-2-oxo-2H-1-benzopyran-3-yl)amino]carbonyl]-4-methyl-1H-pyrrole-3-carboxylate
Reference
  Authors
Pojer F, Li SM, Heide L.
  Title
Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics.
  Journal
Microbiology 148:3901-11 (2002)
Reference
  Authors
Chen H, Walsh CT.
  Title
Coumarin formation in novobiocin biosynthesis: beta-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI.
  Journal
Chem Biol 8:301-12 (2001)
Reference
  Authors
Schmutz E, Steffensky M, Schmidt J, Porzel A, Li SM, Heide L.
  Title
An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489.
  Journal
Eur J Biochem 270:4413-9 (2003)
Reference
  Authors
Xu H, Kahlich R, Kammerer B, Heide L, Li SM.
  Title
CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin.
  Journal
Microbiology 149:2183-91 (2003)
Reference
  Authors
Xu H, Wang ZX, Schmidt J, Heide L, Li SM.
  Title
Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin.
  Journal
Mol Genet Genomics 268:387-96 (2002)
Reference
  Authors
Freel Meyers CL, Oberthur M, Xu H, Heide L, Kahne D, Walsh CT
  Title
Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring.
  Journal
Angew Chem Int Ed Engl 43:67-70 (2004)
Reference
  Authors
Pojer F, Kahlich R, Kammerer B, Li SM, Heide L.
  Title
CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis.
  Journal
J Biol Chem 278:30661-8 (2003)
Reference
  Authors
Li SM, Westrich L, Schmidt J, Kuhnt C, Heide L.
  Title
Methyltransferase genes in Streptomyces rishiriensis: new coumermycin derivatives from gene-inactivation experiments.
  Journal
Microbiology 148:3317-26 (2002)
Reference
  Authors
Pojer F, Wemakor E, Kammerer B, Chen H, Walsh CT, Li SM, Heide L.
  Title
CloQ, a prenyltransferase involved in clorobiocin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 100:2316-21 (2003)
KO pathway
 

DBGET integrated database retrieval system