KEGG   PATHWAY: sgl00290Help
Entry
sgl00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Sodalis glossinidius
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Valine, leucine and isoleucine biosynthesis
sgl00290

All organismsOrtholog table
Module
Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:sgl00290]
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:sgl00290]
Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:sgl00290]
Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:sgl00290]
Other DBs
Organism
Sodalis glossinidius [GN:sgl]
Gene
SG2393  
threonine dehydratase; K01754 threonine dehydratase [EC:4.3.1.19] [KO:K01754] [EC:4.3.1.19]
SG0435  
isopropylmalate isomerase large subunit; K01703 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35] [KO:K01703] [EC:4.2.1.35 4.2.1.33]
SG0434  
leuD; isopropylmalate isomerase small subunit [KO:K01704] [EC:4.2.1.35 4.2.1.33]
SG0436  
3-isopropylmalate dehydrogenase; K00052 3-isopropylmalate dehydrogenase [EC:1.1.1.85] [KO:K00052] [EC:1.1.1.85]
SG2397  
acetolactate synthase 2 catalytic subunit; K01652 acetolactate synthase I/II/III large subunit [EC:2.2.1.6] [KO:K01652] [EC:2.2.1.6]
SG2396  
ilvM; acetolactate synthase 2 regulatory subunit [KO:K11258] [EC:2.2.1.6]
SG2391  
ketol-acid reductoisomerase; K00053 ketol-acid reductoisomerase [EC:1.1.1.86] [KO:K00053] [EC:1.1.1.86]
SG2394  
dihydroxy-acid dehydratase; K01687 dihydroxy-acid dehydratase [EC:4.2.1.9] [KO:K01687] [EC:4.2.1.9]
SG2395  
branched-chain amino acid aminotransferase; K00826 branched-chain amino acid aminotransferase [EC:2.6.1.42] [KO:K00826] [EC:2.6.1.42]
SG0009  
avtA; valine--pyruvate transaminase [KO:K00835] [EC:2.6.1.66]
SG1602  
aminotransferase; K14260 alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] [KO:K14260] [EC:2.6.1.2 2.6.1.66]
SG0437  
2-isopropylmalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] [KO:K01649] [EC:2.3.3.13]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00109  
2-Oxobutanoate
C00123  
L-Leucine
C00141  
3-Methyl-2-oxobutanoic acid
C00183  
L-Valine
C00188  
L-Threonine
C00233  
4-Methyl-2-oxopentanoate
C00407  
L-Isoleucine
C00671  
(S)-3-Methyl-2-oxopentanoic acid
C02226  
2-Methylmaleate
C02504  
alpha-Isopropylmalate
C02612  
(R)-2-Methylmalate
C02631  
2-Isopropylmaleate
C04181  
3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  
(2S)-2-Isopropyl-3-oxosuccinate
C04272  
(R)-2,3-Dihydroxy-3-methylbutanoate
C04411  
(2R,3S)-3-Isopropylmalate
C06006  
(S)-2-Aceto-2-hydroxybutanoate
C06007  
(R)-2,3-Dihydroxy-3-methylpentanoate
C06010  
(S)-2-Acetolactate
C06032  
D-erythro-3-Methylmalate
C14463  
(R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
KO pathway
 
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