KEGG   PATHWAY: shl00260Help
Entry
shl00260                    Pathway                                

Name
Glycine, serine and threonine metabolism - Shewanella halifaxensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
shl00260  Glycine, serine and threonine metabolism
shl00260

Ortholog table
Module
shl_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:shl00260]
shl_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:shl00260]
shl_M00555  Betaine biosynthesis, choline => betaine [PATH:shl00260]
Other DBs
BSID: 63933
GO: 0006544 0006563 0070178 0006566
Organism
Shewanella halifaxensis [GN:shl]
Gene
Shal_0788  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Shal_1114  aspartate kinase [KO:K12524] [EC:1.1.1.3 2.7.2.4]
Shal_0623  aspartate kinase [KO:K12525] [EC:1.1.1.3 2.7.2.4]
Shal_2643  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Shal_1115  homoserine kinase [KO:K00872] [EC:2.7.1.39]
Shal_1116  threonine synthase [KO:K01733] [EC:4.2.3.1]
Shal_1187  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
Shal_1203  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Shal_3939  Serine--pyruvate transaminase [KO:K00830] [EC:2.6.1.51 2.6.1.45 2.6.1.44]
Shal_0923  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K00018] [EC:1.1.1.29]
Shal_2800  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Shal_0043  phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [KO:K15633] [EC:5.4.2.12]
Shal_0723  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K00058] [EC:1.1.1.399 1.1.1.95]
Shal_2041  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Shal_3131  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
Shal_4215  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
Shal_4216  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
Shal_3373  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
Shal_3375  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Shal_0478  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Shal_3374  glycine cleavage system H protein [KO:K02437]
Shal_0690  Non-specific serine/threonine protein kinase [KO:K00613] [EC:2.1.4.1]
Shal_2058  phospholipase D/Transphosphatidylase [KO:K00998] [EC:2.7.8.8]
Shal_1057  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Shal_1058  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Shal_1608  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
Shal_0824  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
Shal_3940  threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
Shal_3561  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
Shal_1653  tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
Shal_1654  tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  S-Aminomethyldihydrolipoylprotein
C01726  D-Lombricine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02855  N-Phospho-D-lombricine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
KO pathway
ko00260   

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