| Entry |
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| Name |
Nucleotide excision repair - Sulfolobus islandicus M.16.27
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| Description |
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
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| Class |
Genetic Information Processing; Replication and repair
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| Pathway map |
| Nucleotide excision repair |
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| Module |
| DNA polymerase delta complex [PATH: sim03420] | | | | | | | | | | |
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| Other DBs |
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| Organism |
Sulfolobus islandicus M.16.27 [GN: sim]
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| Gene |
| | | single-stranded DNA-binding protein; K07466 replication factor A1 [KO: K07466] | | ERCC4 domain-containing protein; K10848 DNA excision repair protein ERCC-4 [EC:3.1.-.-] [KO: K10848] [EC:3.1.-.-] | | proliferating cell nuclear antigen PcnA; K04802 proliferating cell nuclear antigen [KO: K04802] | | proliferating cell nuclear antigen PcnA; K04802 proliferating cell nuclear antigen [KO: K04802] | | proliferating cell nuclear antigen-like protein; K04802 proliferating cell nuclear antigen [KO: K04802] | | |
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| Reference |
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| Authors |
Sugasawa K. |
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| Title |
[Molecular mechanism of mammalian nucleotide excision repair] Japanese |
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| Journal |
Tanpakushitsu Kakusan Koso 46:893-901 (2001) |
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| Reference |
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| Authors |
Nakatsu Y. |
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| Title |
[Transcription-coupled repair and Cockayne syndrome] Japanese |
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| Journal |
Tanpakushitsu Kakusan Koso 46:908-15 (2001) |
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| Reference |
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| Authors |
Nakagawa N, Masui R, Kuramitsu S. |
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| Title |
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8] Japanese |
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| Journal |
Tanpakushitsu Kakusan Koso 46:968-75 (2001) |
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| Reference |
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| Authors |
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ. |
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| Title |
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship. |
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| Journal |
Neuroscience 145:1388-96 (2007) |
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| Reference |
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| Authors |
Saldivar JS, Wu X, Follen M, Gershenson D. |
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| Title |
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity. |
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| Journal |
Gynecol Oncol 107:S56-71 (2007) |
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| Reference |
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| Authors |
Sugasawa K. |
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| Title |
[DNA repair pathways involving Cul4A ubiquitin ligases] Japanese |
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| Journal |
Tanpakushitsu Kakusan Koso 51:1339-44 (2006) |
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| Reference |
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| Authors |
Ito S, Ando D, Tanaka K. |
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| Title |
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders] Japanese |
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| Journal |
Tanpakushitsu Kakusan Koso 52:1823-31 (2007) |
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| KO pathway |
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