KEGG PATHWAY: sjj02060

PATHWAY: sjj02060

Entry

sjj02060                    Pathway

Name

Phosphotransferase system (PTS) - Streptococcus pneumoniae JJA (serotype 14)

Description

The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.

Class

Environmental Information Processing; Membrane transport

Pathway map

sjj02060

Phosphotransferase system (PTS)

Other DBs

GO:

0009401

TC:

4.A

Organism

Streptococcus pneumoniae JJA (serotype 14) [GN:sjj]

Gene

SPJ_1094

ptsP; phosphoenolpyruvate-protein phosphotransferase [KO:K08483] [EC:2.7.3.9]

SPJ_1096

phosphocarrier protein HPr (Histidine-containing protein) [KO:K02784]

SPJ_1578

pts system maltose- and glucose-specific eiicb component [KO:K02779] [EC:2.7.1.199]

SPJ_0696

pts system, iibc component [KO:K20108] [EC:2.7.1.208]

SPJ_1617

pts system, sucrose-specific iibc component [KO:K02810] [EC:2.7.1.211]

SPJ_1789

treP; pts system, trehalose-specific iibc component [KO:K02819] [EC:2.7.1.201]

SPJ_0385

mannitol-specific phosphotransferase enzyme iia component (pts system mannitol-specific eiia component) (eiia-mtl) (eiii-mtl) [KO:K02798] [EC:2.7.1.197]

SPJ_0383

pts system mannitol-specific eiicb component (eiicb-mtl) (eii-mtl) [KO:K02800] [EC:2.7.1.197]

SPJ_1104

lactose-specific phosphotransferase enzyme iia component (pts system lactose-specific eiia component) (eiia-lac) (eiii-lac) [KO:K02786] [EC:2.7.1.207]

SPJ_1103

PTS system, lactose-specific IIC component [KO:K02788] [EC:2.7.1.207]

SPJ_2030

lichenan-specific phosphotransferase enzyme iia component (pts system lichenan-specific eiia component) (eiia-lic) (eiii-lic) [KO:K02759] [EC:2.7.1.196 2.7.1.205]

SPJ_0260

phosphotransferase system sugar-specific eiia component [KO:K02759] [EC:2.7.1.196 2.7.1.205]

SPJ_1710

lichenan-specific phosphotransferase enzyme iia component (pts system lichenan-specific eiia component) (eiia-lic) (eiii-lic) [KO:K02759] [EC:2.7.1.196 2.7.1.205]

SPJ_2029

cellobiose-specific phosphotransferase enzyme iib component (pts system cellobiose-specific eiib component) (eiib-cel) [KO:K02760] [EC:2.7.1.196 2.7.1.205]

SPJ_0261

phosphotransferase system sugar-specific eiib component [KO:K02760] [EC:2.7.1.196 2.7.1.205]

SPJ_1711

lichenan-specific phosphotransferase enzyme iib component (pts system lichenan-specific eiib component) (eiib-lic) [KO:K02760] [EC:2.7.1.196 2.7.1.205]

SPJ_2028

phosphotransferase system system, cellobiose-specific IIC component [KO:K02761]

SPJ_0262

lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) [KO:K02761]

SPJ_1709

phosphotransferase system [KO:K02761]

SPJ_1713

lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) [KO:K02761]

SPJ_0094

phosphotransferase system sugar-specific EII component [KO:K02793] [EC:2.7.1.191]

SPJ_2190

PTS system, IIA component [KO:K02793] [EC:2.7.1.191]

SPJ_0292

mannose-specific phosphotransferase system component iiab [KO:K02794] [EC:2.7.1.191]

SPJ_0092

PTS system, IIC component [KO:K02795]

SPJ_0291

PTS system sorbose-specific IIc component [KO:K02795]

SPJ_2188

phosphotransferase system sugar-specific EII component [KO:K02795]

SPJ_0093

PTS system, IID component [KO:K02796]

SPJ_0290

PTS system, mannose/fructose/sorbose family, IID component [KO:K02796]

SPJ_2187

mannose permease iid component (pts system mannose-specific eiidcomponent) (eiid-man) (eii-m-man) [KO:K02796]

SPJ_0316

phosphotransferase system sugar-specific EII component [KO:K02744] [EC:2.7.1.-]

SPJ_0318

N-acetylgalactosamine-specific phosphotransferase enzyme iib component2 (pts system n-acetylgalactosamine-specific eiibcomponent 2) (eiib-aga') [KO:K02745] [EC:2.7.1.-]

SPJ_0319

phosphotransferase system sugar-specific EII component [KO:K02746]

SPJ_0320

PTS system, IID component [KO:K02747]

SPJ_0593

phosphotransferase system sugar-specific EII component [KO:K20112] [EC:2.7.1.204]

SPJ_1115

phosphotransferase system sugar-specific EII component [KO:K20112] [EC:2.7.1.204]

SPJ_0594

PTS system, galactose-specific IIB component [KO:K20113] [EC:2.7.1.204]

SPJ_1114

PTS system, galactose-specific IIB component [KO:K20113] [EC:2.7.1.204]

SPJ_0595

phosphotransferase system sugar-specific EII component [KO:K20114]

SPJ_2042

ascorbate-specific phosphotransferase enzyme iia component (pts system ascorbate-specific eiia component) [KO:K02821] [EC:2.7.1.194]

SPJ_2043

ascorbate-specific phosphotransferase enzyme iib component (ascorbate-specific pts system eiib component) [KO:K02822] [EC:2.7.1.194]

SPJ_2155

phosphotransferase system, galactitol-specific IIB component [KO:K02822] [EC:2.7.1.194]

SPJ_2044

ascorbate-specific PTS system enzyme IIC [KO:K03475]

SPJ_2154

ascorbate-specific PTS system enzyme IIC [KO:K03475]

SPJ_0818

PTS system, fructose specific IIABC components [KO:K02770] [EC:2.7.1.202]

SPJ_0817

pfkB; 1-phosphofructokinase [KO:K00882] [EC:2.7.1.56]

Compound

C00022

Pyruvate

C00031

D-Glucose

C00072

Ascorbate

C00074

Phosphoenolpyruvate

C00089

Sucrose

C00092

D-Glucose 6-phosphate

C00095

D-Fructose

C00124

D-Galactose

C00140

N-Acetyl-D-glucosamine

C00159

D-Mannose

C00185

Cellobiose

C00208

Maltose

C00243

Lactose

C00275

D-Mannose 6-phosphate

C00329

D-Glucosamine

C00352

D-Glucosamine 6-phosphate

C00354

D-Fructose 1,6-bisphosphate

C00357

N-Acetyl-D-glucosamine 6-phosphate

C00392

Mannitol

C00644

D-Mannitol 1-phosphate

C00689

alpha,alpha'-Trehalose 6-phosphate

C00697

Nitrogen

C00794

D-Sorbitol

C01083

alpha,alpha-Trehalose

C01094

D-Fructose 1-phosphate

C01096

Sorbitol 6-phosphate

C01113

D-Galactose 6-phosphate

C01132

N-Acetyl-D-galactosamine

C01451

Salicin

C01452

Sorbose

C01674

Chitobiose

C01697

Galactitol

C01798

D-Glucoside

C02262

D-Galactosamine

C02713

N-Acetylmuramate

C02888

Sorbose 1-phosphate

C02995

Maltose 6'-phosphate

C03752

2-Amino-2-deoxy-D-gluconate

C04534

6-Phospho-beta-D-glucosyl-(1,4)-D-glucose

C05396

Lactose 6'-phosphate

C06186

Arbutin

C06187

Arbutin 6-phosphate

C06188

Salicin 6-phosphate

C06311

Galactitol 1-phosphate

C06376

N-Acetyl-D-galactosamine 6-phosphate

C06377

D-Galactosamine 6-phosphate

C11544

2-O-(alpha-D-Mannosyl)-D-glycerate

C16186

L-Ascorbate 6-phosphate

C16488

Fructoselysine

C16489

Fructoselysine 6-phosphate

C16688

Sucrose 6-phosphate

C16698

N-Acetylmuramic acid 6-phosphate

C16699

2-O-(6-Phospho-alpha-mannosyl)-D-glycerate

C20589

D-Glucosaminate-6-phosphate

C20978

Glucoselysine

C20979

Glucoselysine-6-phosphate

C21152

N,N'-Diacetylchitobiose 6'-phosphate

Reference

PMID:11361076

Authors

Darbon E, Galinier A, Le Coq D, Deutscher J.

Title

Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.

Journal

J Mol Microbiol Biotechnol 3:439-44 (2001)

Reference

PMID:15060041

Authors

Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.

Title

Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.

Journal

J Bacteriol 186:2385-92 (2004)
DOI:10.1128/JB.186.8.2385-2392.2004

Reference

PMID:2117666

Authors

Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G

Title

Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.

Journal

J Mol Biol 214:657-71 (1990)
DOI:10.1016/0022-2836(90)90284-S

Reference

PMID:12603740

Authors

Kristich CJ, Glekas GD, Ordal GW.

Title

The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.

Journal

Mol Microbiol 47:1353-66 (2003)
DOI:10.1046/j.1365-2958.2003.03375.x

Reference

PMID:14645248

Authors

Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.

Title

Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.

Journal

J Biol Chem 279:5537-48 (2004)
DOI:10.1074/jbc.M310980200

Reference

PMID:15608210

Authors

Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.

Title

EcoCyc: a comprehensive database resource for Escherichia coli.

Journal

Nucleic Acids Res 33:D334-7 (2005)
DOI:10.1093/nar/gki108

Reference

PMID:18156259

Authors

Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.

Title

Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.

Journal

J Bacteriol 190:1710-7 (2008)
DOI:10.1128/JB.01737-07

Reference

PMID:10931310

Authors

Brinkkotter A, Kloss H, Alpert C, Lengeler JW.

Title

Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.

Journal

Mol Microbiol 37:125-35 (2000)
DOI:10.1046/j.1365-2958.2000.01969.x

Reference

PMID:11361063

Authors

Tchieu JH, Norris V, Edwards JS, Saier MH Jr.

Title

The complete phosphotranferase system in Escherichia coli.

Journal

J Mol Microbiol Biotechnol 3:329-46 (2001)

Reference

PMID:16233138

Authors

Kotrba P, Inui M, Yukawa H.

Title

Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.

Journal

J Biosci Bioeng 92:502-17 (2001)
DOI:10.1016/S1389-1723(01)80308-X

Related
pathway

sjj00051

Fructose and mannose metabolism

KO pathway

ko02060

All links

Genome (1)   
   KEGG GENOME (1)   
Gene (45)   
   KEGG GENES (45)   
All databases (46)   

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