KEGG   PATHWAY: sli03440Help
Entry
sli03440                    Pathway                                

Name
Homologous recombination - Spirosoma linguale
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
sli03440  Homologous recombination
sli03440

Ortholog table
Module
sli_M00260  DNA polymerase III complex, bacteria [PATH:sli03440]
Other DBs
BSID: 134096
GO: 0000724
Organism
Spirosoma linguale [GN:sli]
Gene
Slin_1195  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Slin_5984  single-strand binding protein [KO:K03111]
Slin_5508  DNA replication and repair protein RecF [KO:K03629]
Slin_1197  DNA repair protein RecO [KO:K03584]
Slin_1600  recombination protein RecR [KO:K06187]
Slin_5034  recA protein [KO:K03553]
Slin_0543  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Slin_4502  Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
Slin_5229  Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
Slin_2240  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
Slin_2477  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
Slin_0531  DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
Slin_4880  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
Slin_0023  DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Slin_1937  DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
Slin_6089  DNA polymerase III gamma/tau subunits-like protein [KO:K02341] [EC:2.7.7.7]
Slin_5942  exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Slin_5255  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
Slin_6834  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Slin_2705  exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Slin_4062  primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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