KEGG   PATHWAY: spa03060Help
Entry
spa03060                    Pathway                                

Name
Protein export - Streptococcus pyogenes MGAS10394 (serotype M6)
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
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Protein export
spa03060

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Organism
Streptococcus pyogenes MGAS10394 (serotype M6) [GN:spa]
Gene
secY; preprotein translocase subunit SecY [KO:K03076]
secE; preprotein translocase subunit SecE [KO:K03073]
secG; preprotein translocase subunit SecG [KO:K03075]
yajC; preprotein translocase subunit YajC [KO:K03210]
hypothetical protein; K03217 YidC/Oxa1 family membrane protein insertase [KO:K03217]
OxaA-like protein precursor; K03217 YidC/Oxa1 family membrane protein insertase [KO:K03217]
secA; preprotein translocase subunit SecA [KO:K03070]
signal recognition particle subunit FFH; K03106 signal recognition particle subunit SRP54 [KO:K03106]
cell division protein ftsY; K03110 fused signal recognition particle receptor [KO:K03110]
Signal peptidase I; K03100 signal peptidase I [EC:3.4.21.89] [KO:K03100] [EC:3.4.21.89]
Signal peptidase I; K03100 signal peptidase I [EC:3.4.21.89] [KO:K03100] [EC:3.4.21.89]
lipoprotein signal peptidase; K03101 signal peptidase II [EC:3.4.23.36] [KO:K03101] [EC:3.4.23.36]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
KO pathway
 

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